242 research outputs found
Correspondence : Booth (John Cornelius) and Engelmann (George), 1880
No full textBooth to Engelmann, 188
Letter from [author unknown] to John Muir, 1884 Apr 2
No full textDr. George Engelmann Born at Frankfurt on the Main, February 2nd, 1809 DIED, In the midst of his scientific labors at his more in St. Louis, on Monday, February 4th, 1884, in the seventy-fifth year of his age 3003 Locust Street, St. Louis March 10th, 1884https://scholarlycommons.pacific.edu/jmcl/44166/thumbnail.jp
Cornelius Tacitus über die Weltstellung von Germanien. [microform] = de situ Germaniae liber, nach der Lesart aller Handschriften ins besondere der Münchener, Stuttgarter und Florentiner : wiederhergestellte lateinische Fassung /
No full textFilmed with: Paucker, C. von / Addenda lexicis Latinis -- Modi, M. / Horatius es Baccylides -- Witkowski, S. / De Lucani schedis Cracoviensibus -- Wilde, C. G. I. / De Plinii Caecilii secundi et imperatoris Trajani epistulis mutuis disputatio -- Mohr, M. / Quellen des Plutarchischen und Nepotischen "Themistocles" ... -- Müller, K. F. / Leichenwagen Alexanders des Grossen -- Montijn, C. G. M. / Specimen literarium inaugurale exhibens quaestiones et explicationes Platonicas -- Miodonski, A. S. / De enuntiatis subiecto carentibus apud Herodotum -- Michelet, K. L. / Forum Romanum oder die achte Region des alten Rom -- Schütze, R. / Juvenalis ethicas -- Uhlmann, G. / De Sex. Properti genere dicendi -- Urlichs, L. von / Pergamenische Inschriften -- Vos, B. H. / Rechtsgeschiedkundige beschouwingen over het Romeinsche Huwelijk -- Schröder, H. / Lukrez und Thucydides -- Stuhl, C. / Quibus condicionibus Tacitus ellipsim verbi admiserit et qua ratione excoluerit -- Thiel, P. N. M. / Bedeutungen des Wortes Hypothesis bei Aristoteles -- Smit, P. J. / Observationes ad Dionysii Halicarnassensis antiquitates Romanas -- Galen ; Schöne, H. / Galenus de partibus artis medicativae -- Schnitzer, C. F. / Quaestionum Ciceronianarum particula secunda -- Schneider, G. / De causa finali Aristotelea -- Schnetz, J. / Kritiker des Valerius Maximus im 9. Jahrhundert -- Müller, E. / De Graecorum deorum partibus Aeschyleis -- Neumann, O. / De Propertii codicibus Urbinate 641, Lusatico, Vaticano 3273 -- Sakellaropoulos, S. K. / Logos eisiterios eis to mathema tes romaikes grammatologias -- Pais, A. / Osservazioni intorno ad una iscrizione scoperta a Tegea -- Patin, A. / Herakitische Beispiele (1. Hälfte.)No more published.Microfilm.Mode of access: Internet
Repression of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response
No full textThe hepatic acute-phase response is characterized by a massive upregulation of serum proteins, such as haptoglobin and serum amyloid A, at the expense of liver homeostatic functions. Although the transcription factor hepatocyte nuclear factor 4 alpha (HNF4A) has a well-established role in safeguarding liver function and its cistrome spans around 50% of liver-specific genes, its role in the acute-phase response has received little attention so far. We demonstrate that HNF4A binds to and represses acute-phase genes under basal conditions. The reprogramming of hepatic transcription during inflammation necessitates loss of HNF4A function to allow expression of acute-phase genes while liver homeostatic genes are repressed. In a pre-clinical liver organoid model overexpression of HNF4A maintained liver functionality in spite of inflammation-induced cell damage. Conversely, HNF4A overexpression potently impaired the acute-phase response by retaining chromatin at regulatory regions of acute-phase genes inaccessible to transcription. Taken together, our data extend the understanding of dual HNF4A action as transcriptional activator and repressor, establishing HNF4A as gatekeeper for the hepatic acute-phase response
Über die Hornhaut des Auges
No full textÜBER DIE HORNHAUT DES AUGES
Franciscus Cornelius Donders Library (-)
Über die Hornhaut des Auges (-
The effects of climate on Engelmann spruce regeneration and vigor
No full text2017 Fall.Includes bibliographical references.Recent climate modeling suggests that drought will become more frequent in the southern Rocky Mountains over the next century. Understanding how tree species will respond and adapt to this changing climate is vital to guide future management decisions by land managers. Future increases in drought frequency and severity will likely have an impact on the composition of forests. Modeling studies have been used to predict the effect that increasing drought will have on Engelmann spruce in southwest Colorado, but little field data has been gathered to validate this modeling. This study uses empirical data to test whether drought conditions are related to decreases in seedling establishment and tree vigor. Annual regeneration data from 1990 to 2009 was collected from 24 sites with 30-year PRISM precipitation normals ranging from 531 mm to 924 mm to determine if dry and wet sites respond differently to drought. Elevations of our study sites ranged from 3100 m to 3500 m above sea level. Among these 24 sites, we found the number of seedlings per hectare varied between 1804 and 18975. We used a mixed effects model to identify climate variables important to annual seedling establishment density. A separate provenance study on the White River National Forest was analyzed to identify drought effects on tree vigor. Engelmann spruce bareroot seedlings from twenty sources ranging from British Columbia to New Mexico were planted in 1970 at an elevation of 2930 m north of Vail, Colorado. Annual precipitation normals of the 20 seed sources ranged from 423 – 1918 mm. We collected increment cores from six to eight trees from each of the 20 seed sources in 2016, and standardized the chronology of each tree using standard dendrochronological techniques. We then analyzed the annual radial growth response of each provenance to a period of severe drought from 2000-2004 using both RWI and a resistance/resilience framework. For both parts of our study, we found weather variability and drought did not impact regeneration or vigor as much as hypothesized, suggesting regeneration and vigor of spruce in these high elevation forests are not reduced by contemporary levels of drought
Prognose bestimmende inflammatorische Marker der Leberzirrhose
No full textDie Leberzirrhose ist eine Erkrankung mit häufig progredientem Verlauf. Patienten entwickeln vermehrt Zirrhose-assoziierte Komplikationen (dekompensierte Leberzirrhose) und sterben letztendlich häufig am sogenannten akut-auf-chronischen Leberversagen mit Multiorganversagen. Bakterielle Infektionen und eine systemische Inflammationreaktion wind wesentliche Faktoren, welche den Verlauf der Erkrankung bestimmen. Allerdings sind die diagnostischen und therapeutischen Optionen bisher unzureichend, um die hohe Letalität der Zirrhose im Endstadium zu verbessern. Ziel der hier gezeigten Habilitationsarbeit war es daher, prognostische Parameter für Patienten mit fortgeschrittener Leberzirrhose zu evaluieren und damit eine Grundlage für die Anpassung von Management-Strategien für Patienten zu liefern. Über den Prognosescore CLIF-C ACLF Score war es möglich Patienten mit besonders hohem Sterberisiko und Dringlichkeit zur Anpassung der Behandlung zu identifizieren. Es zeigte sich, dass eine Dysfunktion der peritonealen neutrophilen Granulozyten für die hohe Rate an infektiösen Komplikation, insbesondere im Peritoneum, verantwortlich sein können und dass eine übermäßige Aktivierung von Neutrophilen und Monozyten mit Sequestration von Mikropartikeln im Aszites Ausdruck einer allgemeinen Immunaktivierung und schlechter Prognose sind. Zudem konnten neue PCR (polymerase chain reaction) basierte Methoden etabliert werden, über die eine rasche Identifikation und Charakterisierung von bakteriellen und fungalen Infektionen möglich ist.
Auf Grundlage dieser Ergebnisse sollte nun in Zukunft evaluiert werden, ob gezielte Anpassung der Diagnostik und Therapie die Prognose von Patienten mit fortgeschrittener Leberzirrhose verbessern kann
Synergisms of stem cell mobilisation and toll-like receptor 4 inhibition to treat the acute-on-chronic liver failure
No full textBackground: The acute-on-chronic liver failure (ACLF) is a complex disease
with high mortality without effective therapeutic opportunities. A greater
understanding of disease mechanisms is necessary to identify novel targets
for disease modifying therapies. Systemic inflammation is central and toll-like
receptor 4 (TLR4) may be an important pathway involved in activating
immune cells. Granulocyte-colony stimulating factor (G-CSF) mobilises
immunomodulatory stem- and immune cells and pivotal clinical studies
provided promising results in liver disease.
Aims: I aimed to understand the role of TLR4 in mediating inflammation and
organ injury in ACLF. I also explored how G-CSF exerts its
immunomodulatory capacities in ACLF and whether combing G-CSF with
TLR4 signalling inhibition by TAK-242 might act synergistically.
Methods: The first experimental part comprised human samples, and septic
ACLF rodent models in which I evaluated the role of TLR4 in mediating
inflammation and organ injury. The second clinical part was based on a
multicentre interventional trial evaluating the impact of G-CSF on the
outcome of humans with ACLF. In the third experimental part G-CSF and
TAK-242 were used as therapy in a septic and in a sterile ACLF mouse
model to evaluate synergisms of both therapies.
Results: The first part showed that TLR4 signalling prompted cytokine
release and organ injury causing deaths in ACLF. TLR4 signalling inhibition
by TAK-242 prevented tissue injury and fatalities. The clinical trial revealed
that G-CSF was ineffective in ACLF. In the septic mouse model of ACLF GCSF
alone exaggerated the inflammatory response. The combinatory therapy G-CSF plus TAK-242 acted synergistically by reducing organ injury
and promoting tissue repair.
Conclusion: This study highlighted the complexity of ACLF and introduced
TLR4 mediated inflammation as a central pathomechanistic element. It also
emphasized that combinatory therapies may be necessary to address the
whole spectrum of pathomechanisms involved in ACLF
Impacts of coarse woody debris and edge effects on Engelmann spruce regeneration
No full text2016 Summer.Includes bibliographical references.Engelmann spruce (Picea engelmannii Parry ex Engelm.) is a notoriously difficult species to regenerate, and there has been a history of regeneration failures following group selection cuts on the Uncompahgre Plateau. Our goal was to investigate edge effects and coarse woody debris management on regeneration success in group selection openings. Group selection is an uneven-aged system used in the West to regenerate high elevation spruce-fir forests with small (<1 ac) openings. We implemented an Engelmann spruce germination study on the Uncompahgre Plateau in group selection openings. Permanent plots were installed in spring of 2015. We altered microsite conditions by manipulating coarse woody debris amounts at varying distances from the north and south edges in combination with scarification. Findings show that the southern edge provides a benefit to spruce germination through 23 meters. Coarse woody debris was significantly beneficial at all distances from edge, and without coarse woody debris germination was extremely low
Predatory and energetic relations of woodpeckers to the Engelmann spruce beetle
No full textIncludes bibliographical references.June, 1967.A general theory of the population dynamics of predator-prey systems was developed from a survey of pertinent literature. According to the theory, populations of simplified predator-prey systems fluctuate wildly and periodically. Complicating factors dampen the amplitude of the population fluctuations and thus exert a stabilizing influence on the systems. The predator-prey system between the Northern Three-toed, Hairy and Downy Woodpeckers, and the Engelmann spruce beetle was chosen for an investigation of the population dynamics of a natural predator-prey system. The population densities of several species of bark beetles attracted to trees killed and damaged by a fire on the study area in Northern Colorado, increased to levels that attracted the feeding attention of the woodpeckers. The numerical response of the woodpeckers to prey density was graded, that of the Northern Three-toed Woodpecker was the most pronounced and that of the Downy Woodpecker was the least pronounced. Spatial and temporal differences were noted in the foraging behavior of the three species of woodpeckers; similar but less apparent differences were also noted in the foraging behavior between the sexes of the Northern Three-toed and Hairy Woodpeckers. Both the interspecific and intersexual differences in foraging behavior were correlated with morphological and dietary differences. The metabolic demands of free-living woodpeckers were estimated by feeding diets of known caloric content to active woodpeckers in cages at several different ambient temperatures. Estimates were also made of the caloric content of Engelmann spruce beetle larvae and the rate at which they are digested by the woodpeckers. Combining these estimates with the estimates of the relative densities of woodpeckers, and the average number of spruce beetle larvae found per woodpecker stomach made it possible to calculate the number of larvae consumed by each species of woodpecker. This method gave results very similar to the usual method whereby the number of larvae surviving in bark protected from woodpeckers is compared with the number surviving in bark exposed to woodpeckers. Every aspect of the predator-prey system between woodpeckers and the Engelmann spruce beetle, except the number of larvae destroyed, conforms to general theory. The number of prey destroyed in this predator-prey system is higher than that known for any other system between vertebrate predators and invertebrate prey
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