159 research outputs found
Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs
No full textTheis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol 6293. Berlin: Springer; 2010: 52-64.We present three heuristic strategies for folding RNA sequences into secondary structures including kissing hairpin motifs. The new idea is to construct a kissing hairpin motif from an overlay of two simple canonical pseudoknots. The difficulty is that the overlay does not satisfy Bellman's Principle of Optimality, and the kissing hairpin cannot simply be built from optimal pseudoknots. Our strategies have time/space complexities of O(n^4)/O(n^2), O(n^4)/O(n^3), and O(n^5)/O(n^2). All strategies have been implemented in the program pKiss and were evaluated against known structures. Surprisingly, our simplest strategy performs best. As it has the same complexity as the previous algorithm for simple pseudoknots, the overlay idea opens a way to construct a variety of practically useful algorithms for pseudoknots of higher topological complexity within O(n^4) time and O(n^2) space
Application and Use of Multivariate Control Charts In a BTA Deep Hole Drilling Process
No full textDeep hole drilling methods are used for producing holes with a high length-to-diameter ratio, good surface finish and straightness. The process is subject to dynamic disturbances usually classified as either chatter vibration or spiralling. In this paper, we will focus on the application and use of multivariate control charts to monitor the process in order to detect chatter vibrations. The results showed that chatter is detected and some alarm signals occurs at time points which can be connected to physical changes of the process. --
KnotInFrame: prediction of –1 ribosomal frameshift events
No full textTheis C, Reeder J, Giegerich R. KnotInFrame: prediction of –1 ribosomal frameshift events. Nucleic Acids Research. 2008;36(18):6013-6020.Programmed –1 ribosomal frameshift (–1 PRF) allows for alternative reading frames within one mRNA. First found in several viruses, it is now believed to exist in all kingdoms of life. Strong stimulators for –1 PRF are a heptameric slippery site and an RNA pseudoknot. Here, we present a new algorithm KnotInFrame, for the automatic detection of –1 PRF signals from genomic sequences. It finds the frameshifting stimulators by means of a specialized RNA-pseudoknot folding program, fast enough for genome-wide analyses. Evaluations on known –1 PRF signals demonstrate a high sensitivity
REPRESENTASI THEIS DALAM LIRIK LAGU SYAIR MANUNGGAL KARYA CUPUMANIK
No full textAbstrak
Tujuan penelitian ini adalah untuk mengetahui Representasi Theis Dalam Lirik Lagu Syair Manunggal Karya Grup Musik Cupumanik. Penelitian yang digunakan adalah paradigma konstruktivis dengan pendekatan kualitatif. Analisis dikaji dikaji dengan menggunakan metode penelitian semiotika Roland Barthes. Metode ini menekankan pada makna denotasi, konotasi, dan mitos. Selanjutnya, penulis menambahkan dengan temuan makna yang mengarahkan pada representasi theis yang terdapat pada lirik tersebut yang ditulis oleh Cupumanik. Dari data yang dikaji melalui semiotika Barthes, diperoleh beberapa hasil, yaitu: makna denotasi yang memperlihatkan sebuah keyakinan akan paham bertuhan dan mempercayai eksistensiNya yang diwakili oleh bait reff pada lagu ini. Untuk analisis pada makna konotasi, Pencipta lagu ingin menjadikan lagu ini sebagai refleksi diri untuk dirinya sendiri dalam upaya pendakian spiritualitas dan memeluk ‘Dia’ yang tak bisa dijelaskan oleh apapun dengan cara menggunakan rasa dan kesadaran yang ada pada diri manusia. Pada analisis mitos, Mitos yang dibangun Mitos yang dipahami masyarakat dan menjadi konsep masyarakat yaitu bahwa meyakini serta mempercayai akan kehadiran Tuhan itu sebuah keharusan dalam berkehidupan, agar dapat mensyukuri atas semua nikmat dan ciptaan Tuhan.
Kata Kunci: Semiotika, Lirik Lagu, Representasi, Theis, Roland Barthes
Abstract
The purpose of this study is to know Theist Representation In Song Lyrics Syair Manunggal Karya Music Group Cupumanik. The research used is constructivist paradigm with qualitative approach. The analysis was assessed using Roland Barthes's semiotics research method. This method emphasizes the meaning of denotation, connotation, and myth. Furthermore, the author adds with the findings of meaning that lead to the theis representation contained in the lyrics written by Cupumanik. From the data examined through the semiotics of Barthes, there are several results, namely: the meaning of denotation which shows a belief in godly understanding and believes in the existence of which is represented by the temple of reff on this song. For an analysis of the meaning of connotation, the songwriter wants to make this song a self-reflection for his attempts to climb spirituality and embrace 'Him' which can not be explained by anything by using the sense and awareness that exist in man. In the myth analysis, the myth that built the Myths understood by society and became the concept of society is that believing and believing in the presence of God is a must in life, in order to be grateful for all the favors and creations of God.
Keywords: Semiotics, Song Lyrics, Representation, Theis, Roland Barthe
Ethical Issues
No full textThe author maintains that consideration of ethical issues from a
nursing perspective must acknowledge that the multiple roles of the nurse as
hospital employee, assistant to the physician, and patient advocate result in
conflicting obligations and loyalties and in problems of conscience. Theis
argues that such conflicts produce moral anguish for nurses, particularly for
those in intensive care units, newborn nurseries, or nursing homes. She cites
three cases where nurses felt obligated to act against authority and where the
ultimate involvement of the law resulted in damage to all concerned. She
points out that, because nurses possess a special understanding of the burdens
and benefits of treatment to patients, they should be involved in decision
making to promote the patient's autonomy, dignity, and best interests. (KIE
abstract
En quel sens l'«Unique fondement possible d'une démonstration de l'existence de Dieu» de Kant est-il «unique» fondement «possible»?
No full textThe author examines the sting inherent in the title of Kant's work on the Unique possible foundation of a demonstration of the existence of God, published in 1762. In this work, Kant admits not wanting to establish a formal demonstration of the existence of God, but only the foundations of such a demonstration. In this way, he develops less than a proof, but at the same time more, i.e. the unique possible foundation of such a proof. The author critically analyses that in this formula, obviously to a different extent, both the leibnizian proof starting from the possibles and the wolffian, so-called a posteriori proof, at a critical moment of their respective articulations, resort to a second argumentation in order to prove the existence of the necessary being and that they are thus not auto-sufficient (unique).L'auteur s'interroge sur la pointe que contient le titre de l'ouvrage kantien sur l'Unique fondement possible d'une démonstration de l'existence de Dieu paru en 1762. Kant y affirme, non pas vouloir établir une démonstration en forme de l'existence de Dieu, mais uniquement le fondement d'une telle démonstration. Dans ce sens, il développe moins qu'une preuve, mais en même temps plus, à savoir l'unique fondement possible d'une telle preuve. L'auteur montre que dans cette formulation sont visées de façon critique — à des titres différents certes — la preuve leibnizienne à partir des possibles et la preuve wolffienne dite a posteriori qui, toutes les deux, recourent, à un moment crucial de leurs articulations respectives, à une seconde argumentation pour démontrer l'existence de l'être nécessaire et qu'elles ne sont pas, de ce fait, auto-suffisantes (uniques).Theis Robert. En quel sens l'«Unique fondement possible d'une démonstration de l'existence de Dieu» de Kant est-il «unique» fondement «possible»?. In: Revue Philosophique de Louvain. Quatrième série, tome 95, n°1, 1997. pp. 7-23
En quel sens l'«Unique fondement possible d'une démonstration de l'existence de Dieu» de Kant est-il «unique» fondement «possible»?
No full textThe author examines the sting inherent in the title of Kant's work on the Unique possible foundation of a demonstration of the existence of God, published in 1762. In this work, Kant admits not wanting to establish a formal demonstration of the existence of God, but only the foundations of such a demonstration. In this way, he develops less than a proof, but at the same time more, i.e. the unique possible foundation of such a proof. The author critically analyses that in this formula, obviously to a different extent, both the leibnizian proof starting from the possibles and the wolffian, so-called a posteriori proof, at a critical moment of their respective articulations, resort to a second argumentation in order to prove the existence of the necessary being and that they are thus not auto-sufficient (unique).L'auteur s'interroge sur la pointe que contient le titre de l'ouvrage kantien sur l'Unique fondement possible d'une démonstration de l'existence de Dieu paru en 1762. Kant y affirme, non pas vouloir établir une démonstration en forme de l'existence de Dieu, mais uniquement le fondement d'une telle démonstration. Dans ce sens, il développe moins qu'une preuve, mais en même temps plus, à savoir l'unique fondement possible d'une telle preuve. L'auteur montre que dans cette formulation sont visées de façon critique — à des titres différents certes — la preuve leibnizienne à partir des possibles et la preuve wolffienne dite a posteriori qui, toutes les deux, recourent, à un moment crucial de leurs articulations respectives, à une seconde argumentation pour démontrer l'existence de l'être nécessaire et qu'elles ne sont pas, de ce fait, auto-suffisantes (uniques).Theis Robert. En quel sens l'«Unique fondement possible d'une démonstration de l'existence de Dieu» de Kant est-il «unique» fondement «possible»?. In: Revue Philosophique de Louvain. Quatrième série, tome 95, n°1, 1997. pp. 7-23
Discussion of 'Diagnostic curve for confined aquifer parameters from early drawdowns' by Sushil K. Singh
No full textThe determination of aquifer parameters is fundamental to groundwater resources assessment. This important topic has received much attention in the literature over many years. Singh (2008) presented a method for determination of parameters for an ideal confined aquifer, based on early drawdown data. The Theis well function (Theis 1935), the topic of interest here, arises as a core part of the analysis. It is, of course, essential that approximations to the Theis well function be robust and accurate so that reliable estimates of aquifer parameters are obtained. Two approximations for the Theis well function were presented by Singh (2008). The purposes of this discussion were (1) to examine these two approximations, in particular their relative error as reported by the author, and (2) to alert readers to an existing, easy-to-calculate approximation to the Theis well function.ECO
Общественная концепция личности и жанрово-стилистичестсие характеристистики текстов в средствах массовой информации
No full textMedia's texts have never Ьееn homogeneous, not Ьefore or after perestroyka. The differences between them were based on the author 's attitude to the conception of the individual expressed Ьу the society. Before perestroyka some texts expressed theis dominating canon in а numЬer of·conceptual, genre and language cliches, others, in the frames of canon, filled idiological vocabulary with conerete meanings. At the postperestroyka period the media's texts are classified Ьу the other reasons. Some of them creating theis own conception of the individual develop the values of а human being as а synthesis of his Ьiological, spiritual and social qualities. Others determin Ьiological and unconscious qualities to Ье theis prioritets, and that's uhy theis plots are limited Ьу the sensational information and scandals.Text's differentiation of the both periods touchs genre characteristics, communicalional ramer, modality and emotional description
Общественная концепция личности и жанрово-стилистичестсие характеристистики текстов в средствах массовой информации
No full textMedia's texts have never Ьееn homogeneous, not Ьefore or after perestroyka. The differences between them were based on the author 's attitude to the conception of the individual expressed Ьу the society. Before perestroyka some texts expressed theis dominating canon in а numЬer of·conceptual, genre and language cliches, others, in the frames of canon, filled idiological vocabulary with conerete meanings. At the postperestroyka period the media's texts are classified Ьу the other reasons. Some of them creating theis own conception of the individual develop the values of а human being as а synthesis of his Ьiological, spiritual and social qualities. Others determin Ьiological and unconscious qualities to Ье theis prioritets, and that's uhy theis plots are limited Ьу the sensational information and scandals.Text's differentiation of the both periods touchs genre characteristics, communicalional ramer, modality and emotional description
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