1,355,091 research outputs found
Early features of autism spectrum disorder: a cross-sectional study.
No full textBACKGROUND: Autism spectrum disorder is characterized by impairment in social interaction and communication along with repetitive, restricted, and stereotyped behaviors, interests and activities. It is important to detect this condition as soon as possible and promptly begin targeted treatments. This study aimed to report on age at onset, early signs, and mode at onset in 105 Italian patients with autism spectrum disorder, searching for correlations with a series of clinical and instrumental variables. METHODS: This retrospective cross-sectional study considered the following five categories of symptoms at onset: language, social interaction and relationships, stereotyped behavior and activities, motor skills, and regulation. Three modes of presentation were considered: a delay, a stagnation, or a regression of development, which were defined modes of onset of autism spectrum disorder. The age at onset, the category of clinical features, and the mode at onset were considered in the entire sample and statistically analyzed for several clinical variables. Statistical analysis was performed utilizing Fisher Exact test and Chi Square test. RESULTS: The first symptoms between 7 and 12 months were evident in 41.9% of cases, and between 13 and 24 months in 27.6%; no significant differences for the age at onset related to diagnosis, etiopathogenesis, early onset epilepsy, and intelligence quotient level emerged. Social interaction and relationships (93.3%) and language (92.4%) were the categories of early signs more represented in our sample. Delay in spoken language (to be understood as both verbal production and verbal comprehension) was one of the most common (even though not specific) symptoms prompting initial medical consultation for a possible diagnosis of autism spectrum disorder. At onset, patients without intellectual disability manifested stagnation more often than delay or regression of development; patients with a severe/profound intellectual disability more frequently showed delay or regression of development. Language signs at onset were less frequent in cases with regression, whereas motor skill disorders prevailed in cases with delay at onset. Feeding problems were more numerous in cases with delay and stagnation of development. CONCLUSIONS: These data contribute to identifying an early trend of autism spectrum disorder, useful also for pediatricians
Digital Options for the Rehabilitation of the Atrophic Edentulous Maxilla
No full textObjective:
The aim of this study was to describe fully digital workflows for the Prosthetically Guided Reconstructive Surgery (PGRS) of edentulous patients affected by atrophic maxilla.
Methods:
The preoperative provisional removable full-denture was used as starting point to determine aesthetics parameters, occlusion of the final prosthetic rehabilitation as well as the respective maxillary implant positions using conventional softwares for the diagnosis of available bone and for the design of the full-arch prosthesis. The regenerative option (bone augmentation using customized titanium mesh), or the long implant option (navigated zygomatic implants) were both digitally projected depending on the patient needs. After implants healing, two sets of digital impressions were acquired: set #1 was the digital impression of implant positions; set #2 was the digitalization of the provisional full denture together with the impression of the rear side. The two sets were digitally combined into a single file. The metal framework of the final prosthesis was designed and manufactured using digital hybrid manufacturing technology and clinically evaluated with Sheffield test and radiographs; at the same time a resin prototype was produced for clinical try-in of aesthetic and functional parameters.
Results:
Aesthetic parameters and the occlusion of the provisional removable full-denture were digitally transferred to the provisional and definitive full-arch fixed prosthesis. The digital models were 3D-printed in occlusion to finalize in three steps the full-arch prosthesis.
Conclusions:
The workflows of PGRS allowed realizing the full process of the prosthetic and surgical rehabilitation of edentulous patients with atrophic maxilla using a complete digital CAD-CAM technology.
1: Cordaro L, Amadé DS, Cordaro M. Clinical results of alveolar ridge augmentation with mandibular block bone grafts in partially edentulous patients prior to implant placement. Clin Oral Implants Res. 2002 Feb;13(1):103-11. PubMed PMID: 12005140.
2: Pellegrino G, Lizio G, Corinaldesi G, Marchetti C. Titanium Mesh Technique in Rehabilitation of Totally Edentulous Atrophic Maxillae: A Retrospective Case Series. J Periodontol. 2016 May;87(5):519-28. doi: 10.1902/jop.2016.150432. Epub 2016 Jan 12. PubMed PMID: 26759078.
3: Tuminelli FJ, Walter LR, Neugarten J, Bedrossian E. Immediate loading of zygomatic implants: A systematic review of implant survival, prosthesis survival and potential complications. Eur J Oral Implantol. 2017;10 Suppl 1:79-87. Review. PubMed PMID: 28944370.
4: Ciocca L, Lizio G, Baldissara P, Sambuco A, Scotti R, Corinaldesi G. Prosthetically CAD-CAM-Guided Bone Augmentation of Atrophic Jaws Using Customized Titanium Mesh: Preliminary Results of an Open Prospective Study. J Oral Implantol. 2018 Apr;44(2):131-137. doi: 10.1563/aaid-joi-D-17-00125. Epub 2018 Jan 5. PubMed PMID: 29303418.
5: Ciocca L, Ragazzini S, Fantini M, Corinaldesi G, Scotti R. Work flow for the prosthetic rehabilitation of atrophic patients with a minimal-intervention CAD/CAM approach. J Prosthet Dent. 2015 Jul;114(1):22-6. doi: 10.1016/j.prosdent.2014.11.014. Epub 2015 Apr 7. PubMed PMID: 25862269
Structural Concrete Prepared with Coarse Recycled Concrete Aggregate: From Investigation to Design
No full textAn investigation of mechanical behaviour and elastic properties of recycled aggregate concrete (RAC) is presented. RACs were prepared by using a coarse aggregate fraction made of recycled concrete coming from a recycling plant in which rubble from concrete structure demolition is collected and suitably treated. Several concrete mixtures were prepared by using either the only virgin aggregates (as reference) or 30% coarse recycled aggregate replacing gravel and by using two different kinds of cement. Different water-to-cement ratios were adopted ranging from 0.40 to 0.60. Concrete workability was always in the range 190–200 mm. Concrete compressive strength, elastic modulus, and drying shrinkage were evaluated. Results obtained showed that structural concrete up to C32/40 strength class can be manufactured with RAC. Moreover, results obtained from experimentation were discussed in order to obtain useful information for RAC structure design, particularly in terms of elastic modulus and drying shrinkage prediction
Self compacting concrete: a route to high quality concrete structures
No full text“Capacity Building in Environment-related Issues: Recovery and Recycling of Construction Materials”, TWAS (Third World Academy of Science) e FORGEA International (Training and cooperation centre in the field of geo-mining and environment), Monteponi, Iglesias (CA), Italy (scientific director: Prof. S. Meriani
Self compacting concrete: a way to reuse industrial by-products
No full textAtti del VIII Convegno Nazionale sulla Scienza e Tecnologia dei Materiali, Aci Castello (CT)
Metagenetic tools for the census of marine meiofaunal biodiversity: An overview
No full textAbstract
Marine organisms belonging to meiofauna (size range: 20–500 μm) are amongst the most abundant and highly diversified metazoans on Earth including 22 over 35 known animal Phyla and accounting formore than 2/3 of the abundance ofmetazoan organisms. In anymarine system,meiofauna play a key role in the functioning of the food webs and sustain important ecological processes. Estimates of meiofaunal biodiversity have been so far almost exclusively based on morphological analyses, but the very small size of these organisms and, in some cases, the insufficient morphological distinctive features limit considerably the census of the biodiversity of this component. Molecular approaches recently applied also to small invertebrates (including meiofauna) can offer a new momentum for the census of meiofaunal biodiversity. Here, we provide an overview on the application of metagenetic approaches based on the use of next generation sequencing platforms to study meiofaunal biodiversity, with a special focus on marine nematodes. Our overview shows that, although such approaches can represent a useful tool for the census of meiofaunal biodiversity, there are still different shortcomings and pitfalls that prevent their extensive use without the support of the classical taxonomic identification. Future investigations are needed to address these problems and to provide a goodmatch between the contrasting findings emerging from classical taxonomic and molecular/bioinformatic tools
Vertical ridge augmentation with Ti-reinforced dense polytetrafluoroethylene (d-PTFE) membranes or Ti-meshes and collagen membranes: 3-year results of a randomized clinical trial
No full textBackgroundThe present study aimed to evaluate hard and soft tissue parameters around implants placed in augmented posterior mandible, comparing Ti-reinforced d-PTFE membranes with Ti-meshes covered with collagen membranes, after 3 years of follow-up. Materials and MethodsForty eligible patients were randomly assigned to group A (Ti-reinforced d-PTFE membrane) or group B (mesh covered with collagen membrane) for vertical ridge augmentation (VRA) and simultaneous implants. Implants were evaluated using specific peri-implant parameters for bone and soft tissues: probing pocket depth (PPD), modified plaque index (mPI), bleeding on probing (BoP), modified gingival index (mGI), thickness of keratinized tissue (tKT), width of keratinized tissue (wKT), fornix depth (FD), peri-implant bone level (PBL), interproximal bone peaks (IBP), marginal bone loss (MBL), interproximal bone loss (IBL). ResultsA total of 28 patients with 79 implants were evaluated after 3 years of follow-up. The mean value of MBL was 0.70 mm (group A = 0.73 mm; group B = 0.71 mm), while mean IBL was 0.54 mm (group A = 0.64 mm; group B = 0.40 mm). The treatment with meshes resulted not inferior to PTFE and their clinical results appeared similar. A strong correlation between PBL and IBP was confirmed. Both study groups showed an increase of tKT and wKT values. ConclusionIn the posterior mandible, VRA using both techniques provides stable PBLs up to 3 years. A correct soft tissue management and a strict professional oral hygiene protocol play a crucial role on peri-implant health over time
- …
