1,060 research outputs found
In Vitro Activity of Eravacycline against Gram-Negative Bacilli Isolated in Clinical Laboratories Worldwide from 2013 to 2017
No full textEravacycline is a novel, fully synthetic fluorocycline antibiotic developed for the treatment of serious infections, including those caused by multidrug-resistant (MDR) pathogens. Here, we evaluated the in vitro activities of eravacycline and comparator antimicrobial agents against a global collection of frequently encountered clinical isolates of Gram-negative bacilli. The CLSI broth microdilution method was used to determine MIC data for isolates of Enterobacterales (n = 13,983), Acinetobacter baumannii (n = 2,097), Pseudomonas aeruginosa (n = 1,647), and Stenotrophomonas maltophilia (n = 1,210) isolated primarily from respiratory, intra-abdominal, and urinary specimens by clinical laboratories in 36 countries from 2013 to 2017. Susceptibilities were interpreted using both CLSI and EUCAST breakpoints. Multidrug-resistant (MDR) isolates were defined by resistance to agents from ≥3 different antimicrobial classes. The MIC90s ranged from 0.25 to 1 μg/ml for Enterobacteriaceae and were 1 μg/ml for A. baumannii and 2 μg/ml for S. maltophilia, Proteus mirabilis, and Serratia marcescens Eravacycline's potency was up to 4-fold greater than that of tigecycline against genera/species of Enterobacterales, A. baumannii, and S. maltophilia The MIC90s for five of six individual genera/species of Enterobacterales and A. baumannii were within 2-fold of the MIC90s for their respective subsets of MDR isolates, while the MDR subpopulation of Klebsiella spp. demonstrated 4-fold higher MIC90s. Eravacycline demonstrated potent in vitro activity against the majority of clinical isolates of Gram-negative bacilli, including MDR isolates, collected over a 5-year period. This study further underscores the potential benefit of eravacycline in the treatment of infections caused by MDR Gram-negative pathogens
Potential role for telavancin in bacteremic infections due to gram-positive pathogens: Focus on staphylococcus aureus
No full textStaphylococcus aureus bacteremia (SAB) is one of the most common serious bacterial infections and the most frequent invasive infection due to methicillin-resistant S. aureus (MRSA). Treatment is challenging, particularly for MRSA, because of limited treatment options. Telavancin is a bactericidal lipoglycopeptide antibiotic that is active against a range of clinically relevant gram-positive pathogens including MRSA. In experimental animal models of sepsis telavancin was shown to be more effective than vancomycin. In clinically evaluable patients enrolled in a pilot study of uncomplicated SAB, cure rates were 88% for telavancin and 89% for standard therapy. Among patients with infection due to only gram-positive pathogens enrolled in the 2 phase 3 studies of telavancin for treatment of hospital-acquired pneumonia, cure rates for those with bacteremic S. aureus pneumonia were 41% (9/22, telavancin) and 40% (10/25, vancomycin) with identical mortality rates. These data support further evaluation of telavancin in larger, prospective studies of SAB
Characterization and structure in the development of Tudor comedy
No full textThe role of characterization in dramatic structure is assessed by theoretical criteria.
Characters who perform actions necessary for the completion of the narrative sequence are
said to be "bound" to the narrative; those without such obligations are "free". Characters
who maintain a single, constant meaning during the course of a play are said to be "static";
characters who change or develop into new roles are "dynamic". Horatian decorum
demanded that comic characters be static, and the characters of Plautine and Terentian
tradition were almost always bound to narrative intrigue. However, evaluations of six
Tudor comedies show an increasing use of non-classical characterization within the comic
form.
In the early comedies lohan lohan and Roister Doister all characters are bound and
static, yet the impetus to enlarge the role of characterization is evident. The characters of
lohan lohan are expanded from their French source, and Roister Doister includes
extraneous episodes in which Udall displays his braggart hero. Free characters abound in
Misogonus; as well the play brings dynamic characterization into the scope of comedy with
the conversion of its prodigal son.
Free characters offer new possibilities of non-narrative plotting. In comedies of the
1580s favourite traditional characters appear as diversions outside the action, and thematic
arrangements of characters inform the increasingly complex plots. Lyly stresses the
symbolic potential of characters in Endimion, whereas Greene uses dynamic
characterization to heighten the illusion of independent figures in Friar Bacon and Friar
Bungay. Love's Labour's Lost exposes the limitations of comic artifice by pulling the
characters between convention and individualization.
By the end of the sixteenth century free and dynamic characters had become
common, and characterization had established a sizable claim on the design of English
comedy. These developments set the English form apart from its neoclassical counterparts
Journal of Engineering Drawing
No full textAuthors: J. G. McGuire, G. W. Walsh, C. H. Springer, S. A. Coons, Ralph S. Paffenbarger & Ernest R. WeidhassKHD ADDITION:Titles and Authors:Cartography – A Graduate Course in Graphics by J. G. McGuireApplying Graphic Skills to the Solution of Differential Equations by G. W. WalshPersonality Sketch of Professor Randolph P. Hoelscher by C. H. SpringerConic Construction from the Projective Viewpoint by S. A. CoonsCourse Development in Engineering Drawing to Meet the Needs of Present Day Engineering Education by Ralph S. PaffenbargerMotivation as a Teaching Tool by Ernest R. Weidhas
Juanita Abernathy, Ralph D. Abernathy, and Evelyn G. Lowery Holding Arms While Marching Down the Street, 1968
No full textJuanita Abernathy, Ralph D. Abernathy, and Evelyn G. Lowery are shown marching arm in arm down the street with others during a Poor People's Campaign event in Memphis, Tennessee.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Joseph & Evelyn Lowery Institute for Justice and Human Rights, the Joseph Echols Lowery Irrevocable Trust, and other donors in supporting the processing and digitization of Morehouse College's Joseph Echols and Evelyn Gibson Lowery Collection
Privatization of natural monopoly public enterprises : the regulation issue
No full textMany developing countries are considering the privatization of public enterprise natural monopolies. Such as monopolies in charge of electricity, natural gas, waterand sewer, and telephone service. The author tries to answer two questions: (i) how great would the efficiency losses be, if any, if a public natural monopoly were privatized and allowed to function as an unregulated entity? and (ii) how much could performance be expected to improve if the privatized natural monopoly operated as a regular firm? The author argues that the deadweight losses from monopoly pricing by unregulated privatized natural monopolies are likely to be modest and may well be outweighed by improvements in technical efficiency. He also argues that regulation is not costless and may well foster static and dynamic efficiency losses greater than the deadweight monopoly losses it is intended to prevent. Also, the reduction of allocative inefficiency is only one of several objectives of regulation. If the case for regulation on efficiency is weak, then much greater attention must be paid to how these other objectives can best be achieved. Historically, achieving distributional equity has been an important objective of regulation. We have very little systematic knowledge about the actual distributional consequences of privatization and deregulation, so more research is needed.Administrative&Regulatory Law,Economic Theory&Research,Environmental Economics&Policies,Access to Markets,Markets and Market Access
Ralph D. Abernathy and Others During a Poor People's Campaign Event, 1968
No full textRalph D. Abernathy (behind podium), Senator Ted Kennedy, Evelyn G. Lowery, Juanita Abernathy, and others are shown clapping on a stage during a Poor People's Campaign event in Memphis, Tennessee.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Joseph & Evelyn Lowery Institute for Justice and Human Rights, the Joseph Echols Lowery Irrevocable Trust, and other donors in supporting the processing and digitization of Morehouse College's Joseph Echols and Evelyn Gibson Lowery Collection
Emily Brontë : the mind of a visionary
No full textBibliography: leaves 216-226.This dissertation is an investigation of the visionary and philosophical aspects of Emily Brontë's works. The first five chapters deal with the visionary process such as visions, spirit guides, dreams, imagination, encounters with the darker side of the self and a union with the divine. There is considerable evidence of these mystical avenues in both her poetry and in Wuthering Heights which have been explored. It is shown how Emily Brontë's mysticism is a direct result of personal experiences which augment her reputation as one of the leading mystics in the world of literature. There are however tensions in her works, such as the cynicism of her own intellect in accepting the visionary experiences as authentic and periods of suffering when her faith is tested. These tensions have been considered within the context of her mystical encounters and philosophy. The remaining four chapters deal with the philosophy of Emily Brontë per se. Her beliefs in respect of heaven and hell, mercy and justice, power and survival, and pantheism are considered in depth. It is argued that she is an unorthodox thinker who does not believe in an eternal hell and that she has drawn inspiration for this idea from Frederick Maurice and Ralph Waldo Emerson. It is also shown how issues of power have been of interest to her from a young age and how this needs to be integrated within her philosophy. To the writer power needs to be tempered by compassion if it is to be of use to society or the individual. Her pantheistic spirit is also investigated and related to the mystical ideas
Radiolytic Production of Fluorine Gas from MSR Relevant Fluoride Salts
No full textRadiolytic fluorine gas production at temperatures of 40°C to 60°C was investigated for the fluoride salts LiF, BeF2, UF4, ThF4, and 71.7LiF-16BeF2-12.3UF4 (FliBe-UF4) by gamma irradiation of powdered samples using spent fuel elements from the High Flux Reactor (HFR) Petten as the irradiation source; work of a similar nature was previously performed at Oak Ridge National Laboratory in the period 1965 to 1995. Gamma irradiation was conducted for just over 41 days, with total absorbed gamma dose ranging from ~45 MGy for the lightest salts to ~170 MGy for ThF4 and UF4. By measuring the gas pressure within salt-filled capsules during irradiation, it was possible to quantify radiolytic gas production for all salt samples except UF4. Production rates are reported as the salt G-values, measured as number of fluorine molecules produced per 100 eV of energy absorbed (molecules F2/100 eV). The G-values of the salts were found to be G(LiF) ~0.004, G(BeF2) ~0.009, G(ThF4) ~0.021, and G(FLiBe-UF4) ~0.005.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.RST/Reactor Physics and Nuclear Material
- …
