1,721,013 research outputs found
Epilepsy in Mowat-Wilson syndrome: is it a matter of GABA?
No full textFrom our point of view, that is the one of the clinicians,
we strongly support this hypothesis, as the age-related
electroclinical pattern we have detected in vivo is reminiscent
of the idea of a genetic form of epilepsy and is scarcely
influenced by brain macroanatomy.
In conclusion, we feel that these observations could be
of high importance in understanding how epilepsy is determined
in patients with MWS. New interesting scenarios in
terms of treatment are now opened.
DISCLOSUR
Effect of multisensory stimulation on analgesia in term neonates: a randomized controlled trial.
No full textIl fenotipo elettroclinico dell’epilessia nella Sindrome di Mowat-Wilson: uno studio su 22 pazienti
No full text
Bathing epilepsy: report of two Caucasian cases.
No full textBathing epilepsy, also known as water-immersion epilepsy, refers to a rare form of benign reflex epilepsy in which seizures are precipitated by the normal process of domestic bathing. This condition has been confused with true hot water epilepsy, even though bathing in water at normal temperature is the trigger.
Focal seizures predominate with a staring gaze, pallor and generalised features followed by prolonged postictal somnolence. A variable percentage of patients may also show unprovoked seizures. The prognosis is usually favourable, and modifying
bathing habits may prevent further seizures. We report two Caucasian patients with bathing epilepsy. In one, seizures were provoked by water immersion. In the other, we noted an unusual triggering factor; pouring of lukewarm water over the genitalia
Efficacy and safety of felbamate in children under 4 years of age: a retrospective chart review
No full textBACKGROUND AND PURPOSE: To review our experience of the efficacy and tolerability of felbamate in children younger than 4 years.
METHODS: We used a retrospective chart review to identify 53 children with seizures who were younger than 4 years. Efficacy was evaluated based on the occurrence of responsiveness, defined as seizure frequency reduction of more than 50% for a minimum period of 4 months. Tolerability was based on parent-reported side effects.
RESULTS: Twenty-two (41%) patients resulted to be responders and 31 (59%) did not. By univariate analysis, those achieving seizure remission were probably much older, to have a shorter history of epilepsy and a lower frequency of seizures before felbamate therapy. The number of antiepileptic drugs (AEDs) used before felbamate therapy was the only significant predictor of the duration of response to felbamate, with a longer responsiveness to the drug seen in those who were placed under fewer than three AEDs before felbamate compared with those who had taken more than three (median, 16 months vs. 7 months; P < 0.0084). Side effects occurred in 30% of the subjects, but these did not require discontinuation of the drug.
DISCUSSION: Felbamate is an effective medication for a wide range of epilepsy syndromes in children younger than 4 years. Although caution is necessary when the drug is used in children, felbamate might represent a possible option for the treatment of epilepsy in this age group
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