1,600 research outputs found
Mad hats. A reflection on mad leadership
No full textThis paper considers the problem of how Mad leaders might be authentic without resorting to discriminatory identity policing. The paper briefly charts the contemporary role of consumer/survivor/ex-patient/mad activism in mental health reform before drawing on the author’s failed attempt to grapple with authentic mad leadership. Drawing on Mad Studies theory and the wisdom of Lewis Carroll’s Mad Hatter, the author argues that the consumer/survivor/ex-patient/mad movement should welcome all experiences of madness, but only those who can exercise authentic leadership should lead the movement. This requires resistance against non-Mad ways of knowing and exercising power and for established power hierarchies to transform to allow authentic mad leadership. </p
Mad Hatter's tea party flyer
No full textAdvertisement flyer for Mad Hatter's Tea Party, a fundraiser for Gustafson Gallery held at Ammons Hall
Crazy for Wisdom : The Making of a Mad Yogin in Fifteenth-Century Tibet
No full textIn his early twenties, the Tibetan monk Sangyé Gyaltsen (1452–1507) left his monastery to become a wandering tantric yogin. As he moved from place to place, seeking enlightenment beyond the bounds of monasticism, his behavior became increasingly erratic. While some were shocked or even angered by his actions, others were drawn to him. Sangyé Gyaltsen’s followers described his transgressive behaviors as enlightened action, rooted in authoritative Buddhist scripture. Using biographical sources, Stefan Larsson explores Sangyé Gyaltsen’s transformation into the charismatic ‘Madman of Tsang,’ Tsangnyön Heruka. Best known today as the author of the Life of Milarepa, Tsangnyön Heruka was one of the most influential mad yogins of Tibet. His biography brings its reader face-to-face with an unexpected aspect of Buddhist practice that flourished in fifteenth-century Tibet.</p
Visualizing latent domain knowledge
No full textKnowledge discovery and data mining commonly rely on finding salient patterns of association from a vast amount of data. Traditional citation analysis of scientific literature draws insights from strong citation patterns. Latent domain knowledge, in contrast to the mainstream domain knowledge, often consists of highly relevant but relatively infrequently cited scientific works. Visualizing latent domain knowledge presents a significant challenge to knowledge discovery and quantitative studies of science. We build upon a citation-based knowledge visualization procedure and develop an approach that not only captures knowledge structures from prominent and highly cited works, but also traces latent domain knowledge through low-frequency citation chains. We apply this approach to two cases: (1) identifying cross-domain applications of Pathfinder networks (PFNETs) and (2) clarifying the current status of scientific inquiry of a possible link between Bovine spongiform encephalopathy (BSE), also known as mad cow disease, and a new variant Creutzfeldt-Jakob disease (vCJD), a type of brain disease in human
The Mad Hero of Cinema: Scientist as a Mirror of Existential Fears
No full textThis article is dev oted to one of the archetypal images in cinema which have been presented in this art from the first years of its appearance The author considers the image of a mentally inadequate scientist not only from the point of view of his dual goal-setting the search for personal immortality and the desire for total power but for the first time his different semantic content is associated with a stable visual embodiment reproduced in films over the past hundred years The author argues that despite the external historical-political and internal figurative-stylistic and technical conditions this type of media-hero preserved its semantic functions and visual characteristics According to the author this is an objective phenomenon because the image of a mad scientist is an archetypal image and acts as a reflection of collective fears that reflect the drama of human existence namely the insoluble contradiction between his desire for immortality and at the same time the fear of losing all that is the essence of ma
Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction
No full textBone morphogenic protein (BMP) signaling is essential for the coordinated assembly of the synapse, but we know little about how BMP signaling is modulated in neurons. Our findings indicate that the Nemo (Nmo) kinase modulates BMP signaling in motor neurons. nmo mutants show synaptic structural defects at the Drosophila melanogaster larval neuromuscular junction, and providing Nmo in motor neurons rescues these defects. We show that Nmo and the BMP transcription factor Mad can be coimmunoprecipitated and find a genetic interaction between nmo and Mad mutants. Moreover, we demonstrate that Nmo is required for normal distribution and accumulation of phosphorylated Mad in motor neurons. Finally, our results indicate that Nmo phosphorylation of Mad at its N terminus, distinct from the BMP phosphorylation site, is required for normal function of Mad. Based on our findings, we propose a model in which phosphorylation of Mad by Nmo ensures normal accumulation and distribution of Mad and thereby fine tunes BMP signaling in motor neurons.Canadian Institutes of Health ResearchEJLB FoundationGenome Canad
An Efficient overloaded implementation of forward mode automatic differentiation in MATLAB
No full textThe Mad package described here facilitates the evaluation of first derivatives of multidimensional functions that are defined by computer codes written in MATLAB. The underlying algorithm is the well-known forward mode of automatic differentiation implemented via operator overloading on variables of the class fmad. The main distinguishing feature of this MATLAB implementation is the separation of the linear combination of derivative vectors into a separate derivative vector class derivvec. This allows for the straightforward performance optimization of the overall package. Additionally, by internally using a matrix (two-dimensional) representation of arbitrary dimension directional derivatives, we may utilize MATLAB's sparse matrix class to propagate sparse directional derivatives for MATLAB code which uses arbitrary dimension arrays. On several examples, the package is shown to be more efficient than Verma's ADMAT package [Verma 1998a].ACM Transactions on Mathematical Softwar
The Mad Yak
No full textThe Mad Yak, a poem by Gregory Corso, was sung by the author as part of a tribute to Jack Kerouac which was held during Salem State College's Arts Festival in April 1973
To Each Imaging Modality, Their Own MAD
No full textPurpose: The clinical significance of mitral annular disjunction (MAD) is uncertain. Imaging modality might impact the prevalence of MAD. We aimed to assess MAD prevalence at transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) as well as their inter-modality agreement. Methods: This observational retrospective study included patients undergoing TTE and CMR within 6 months. MAD was defined as ≥1 mm systolic separation between the left atrial wall-mitral leaflet and the left ventricular (LV) wall. The maximum MAD longitudinal extent was measured. The inter-modality agreement for MAD diagnosis was evaluated. Results: One hundred twenty four patients (59 ± 17 years; 62% male) were included. MAD was detected in 60 (48%) using CMR and in 10 (8%) using TTE. All patients with MAD on TTE had MAD on CMR. The inter-modality agreement was low (Cohen's kappa = 0.17) but improved when the diagnostic cut-off was increased from 1 to 5 mm (Cohen's kappa = 0.66). The median longitudinal length of MAD was 2.0 mm (25th–75th percentiles: 1.5–3.0) by CMR and 4.0 mm (25th–75th percentiles: 2.7–4.5) by TTE with moderate agreement (intraclass correlation coefficient = 0.66). Conclusion: MAD of limited extent is common on CMR and more than two thirds of patients showing MAD on CMR did not have MAD on TTE. The inter-modality agreement between TTE and CMR increased when the diagnostic threshold for MAD was increased from 1 to 5 mm. Methodological discrepancies impact MAD assessment and contribute to the discordant prevalence and clinical significance reported in the literature. © 2025 The Author(s). Echocardiography published by Wiley Periodicals LLC
"The mad", "the bad", "the victim" : gendered constructions of women who kill within the criminal justice system
No full textWomen commit significantly fewer murders than men and are perceived to be less violent. This belief about women’s non-violence reflects the discourses surrounding gender, all of which assume that women possess certain inherent essential characteristics such as passivity and gentleness. When women commit murder the fundamental social structures based on appropriate feminine gendered behaviour are contradicted and subsequently challenged. This article will explore the gendered constructions of women who kill within the criminal justice system. These women are labelled as either mad, bad or a victim, by both the criminal justice system and society, depending on the construction of their crime, their gender and their sexuality. Symbiotic to labelling women who kill in this way is the denial of their agency. That is to say that labelling these women denies the recognition of their ability to make a semi-autonomous decision to act in a particular way. It is submitted that denying the agency of these women raises a number of issues, including, but not limited to, maintaining the current gendered status quo within the criminal law and criminal justice system, and justice both being done, and being seen to be done, for these women and their victims
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