117,898 research outputs found
IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzymeinhibitors in children and young people with IgA nephropathy and moderateproteinuria.
No full textJ Am Soc Nephrol. 2007 Jun;18(6):1880-8. Epub 2007 May 18.
IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzyme inhibitors in children and young people with IgA nephropathy and moderate proteinuria.
Coppo R, Peruzzi L, Amore A, Piccoli A, Cochat P, Stone R, Kirschstein M, Linné T.
Source
Nephrology, Dialysis and Transplantation Unit, Regina Margherita University Hospital, 10127 Turin, Italy. [email protected]
Abstract
This European Community Biomedicine and Health Research-supported, multicenter, randomized, placebo-controlled, double-blind trial investigated the effect of an angiotensin-converting enzyme inhibitor (ACE-I) in children and young people with IgA nephropathy (IgAN), moderate proteinuria (>1 and 50 ml/min per 1.73 m(2). Sixty-six patients who were 20.5 yr of age (range 9 to 35 yr), were randomly assigned to Benazepril 0.2 mg/kg per d (ACE-I) or placebo and were followed for a median of 38 mo. The primary outcome was the progression of kidney disease, defined as >30% decrease of CrCl; secondary outcomes were (1) a composite end point of >30% decrease of CrCl or worsening of proteinuria until > or =3.5 g/d per 1.73 m(2) and (2) proteinuria partial remission (6 mo. Analysis was by intention to treat. A single patient (3.1%) in the ACE-I group and five (14.7%) in the placebo group showed a worsening of CrCl >30%. The composite end point of >30% decrease of CrCl or worsening of proteinuria until nephrotic range was reached by one (3.1%) of 32 patients in the ACE-I group, and nine (26.5%) of 34 in the placebo group; the difference was significant (log-rank P = 0.035). A stable, partial remission of proteinuria was observed in 13 (40.6%) of 32 patients in the ACE-I group versus three (8.8%) of 34 in the placebo group (log-rank P = 0.033), with total remission in 12.5% of ACE-I-treated patients and in none in the placebo group (log-rank P = 0.029). The multivariate Cox analysis showed that treatment with ACE-I was the independent predictor of prognosis; no influence on the composite end point was found for gender, age, baseline CrCl, systolic or diastolic BP, mean arterial pressure, or proteinuria
1260, Coppo di Marcovaldo, Moscou, Musée Pouchkine (NH 82)
No full textDate 1260 ca Peintre Coppo di Marcovaldo Dates/activité 1225/30 – 1260/1276 Lieu de conservation Moscou, Musée Pouchkine Dimensions (cm) 246 (H) x 138 (l) Position dans l’œuvre entière Au centre : Vierge à l'Enfant colonne de gauche, de haut en bas : Nativité de la Vierge, Présentation au Temple, Annonciation, Visitation, Nativité de Jésus, Annonce aux bergers, Voyage des Mages prédelle, de gauche à droite : Adoration des Mages, Rêve des Mages, Voyage de retour des Mages colonne de ..
The mucosal immune system and IgA nephropathy
No full textThe precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients
Evaluation of nitrous oxide emissions from vineyard soil : effect of organic fertilisation and tillage
No full textIt is well known that the largest source of N2O is the agricultural sector, where fertilization represents the main source of this GHG. Monitoring N2O fluxes for different soil management and crops type is essential to define better N management practices in agro-ecosystems. However, scarce studies have been published about field measurements of organic fertilizers effects in orchards and vineyards.In this paper we present the first long-term high-resolution study on N2O emissions in a vineyard, in temperate climate. The use of dynamic chambers connected directly to an IRGA, allowed to collect one year (from May 2018 to May 2019) of measurements at time resolution of 2 h. The aim of the study was to assess the effect of organic fertilization (compost) and tillage on N2O emissions. Emission factors of uncorrected (EFt) and corrected for no-fertilizer induced emissions (EFf) were calculated.Results showed a seasonal trend in N2O fluxes, with higher base fluxes and peaks during the warm season and in correspondence of rainy events. Emission peak linked to fertilizer application occurred during the first 6-7 days after treatment followed by a decrease in N2O fluxes. Cumulated annual emissions varies between 0.54 and 1.38 kg N2O-N ha-1 y- 1, depending on treatment and level of soil TOC content. The uncorrected EF was between 0.4 and 0.9% of N input, in line with the IPCC value for organic fertilizers in wet climate, while the EFf (referred only to direct fertilizer application) were in range of 0.02-0.4% of N input. We found EFf of fertilized not tilled treatments from 17 to 79% lower than fertilized tilled, with different magnitude of reduction depending on soil TOC. Our EFt were in line with disaggregated EFs from IPCC 2019 but EFf were 43% lower on average, con-firming the IPCC reference value to be a good estimator of the overall N2O emissions from organic fertilized soil, but too high for the estimation of only fertilizer application emissions.These results are of remarkable importance to direct organic fertilization management and related policies towards more environmentally sustainable approaches
Tuning iridium(III) phenylpyridine complexes in the “almost blue” region
No full textWe report on the synthesis and photophysical properties of blue emitting iridium(III) complexes. The use of a negatively charged ligand, such as a triazolyl pyridine, allows a facile preparation, maintaining the high energy emission (blue region) of hetero-leptic complexes. We discuss the role played by electron withdrawing substituents of a different nature and also how the substitution position of the same group influences the spectroscopical behaviour
Confidence intervals for cholesterol bound to high and low density lipoproteins in bovine, equine, swine and canine sera
No full textFil: Coppo, Norma Beatriz. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.Fil: Coppo, José Antonio. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.Fil: Lazarte, M. A. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.Para interpretar adecuadamente el valor del colesterol sérico, actualmente es necesario conocer el tipo de lipoproteína que lo transporta. Con el propósito de obtener valores de referencia y variaciones fisiológicas para colesterol ligado a lipoproteínas de alta y baja densidad (C– HDL y C–LDL), se analizan muestras de 218 animales domésticos ormocolesterolémicos de distinta raza, sexo, edad y tipo de alimentación. Se obtienen intervalos de confianza para C–HDL y C–LDL en bovinos (0,72–0,90 y 0,18–0,26 g/l respectivamente, n = 80), equinos (0,58–0,65 y 0,25–0,34 g/l, n = 49), caninos (1,09–1,25 y 0,31–0,42 g/l, n = 59) y porcinos (0,38–0,46 y 0,30–0,35, n = 30). Se constatan diferencias fisiológicas atribuibles a raza, sexo, edad y dieta. Se ratifica que bovinos, equinos y caninos pertenecen al patrón HDL, por registrar los más altos porcentajes de C–HDL, en tanto que los porcinos encuadran en el patrón LDL por exhibir las más altas tasas de C–LDL.For the correct interpretation of serum cholesterol values, they should be interpreted according to the type of lipoprotein in charge of its transportation. To obtain reference values and physiological variations of cholesterol bounded to high and low density lipoproteins (HDL–C and LDL–C), samples from 218 normocholesterolemic domestic animals from different breed, sex, age and feeding method were analyzed. For this purpose, HDL–C and LDL–C confidence intervals for cattle (0.72–0.90 and 0.18–0.26 g/l respectively, n = 80), horses (0.58–0.65 and 0.25–0.34 g/l, n = 49), dogs (1.09–1.25 and 0.31–0.42 g/l, n = 59) and swines (0.38–0.46 and 0.30–0.35 g/l, n = 30) were obtained. Physiological differences attributable to breed, sex, age and diet were verified. Results allow to state that cattle, horses and dogs belong to HDL pattern, as they register the highest HDL–C percentages, whereas swines belong to the LDL pattern, because they show the highest LDL–C rates
TOWARDS THE INTEGRATION OF MAGNETOTELLURIC WITH GEOLOGICAL SEISMIC AND GRAVITY DATA WITHIN THE SIRIPRO PROJECT
No full textCrisi epilettiche nei disturbi della migrazione: descrizione di tre casi di eterotopia corticale
No full text- …
