111,891 research outputs found
First Report of Southern Blight Caused by Sclerotium rolfsii on Hemp (Cannabis sativa) in Sicily and Southern Italy
No full textauthor-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Metabotropic glutamate receptors and neurodegeneration
No full textMetabotropic glutamate (mGlu) receptors belong to a class of G-protein linked receptors, which also includes the Ca2+-sensing receptor and the gama-aminobutyric acid (GABAB) receptor. A great variety of drugs has been introduced with the intent of limiting some of the intracellular events that occur downstream of the increase in intracellular Ca2+, including free-radical scavengers, protein kinase C inhibitors, calpain inhibitors, nitric oxide synthase inhibitors, and, lately, caspase inhibitors. Activation of group-II mGlu receptors is neuroprotective in a variety of models, including neuronal cultures, brain slices, and in vivo models of excitotoxicity. The experimental therapy of acute or chronic neurodegenerative disorders can be addressed to the ethiology of the specific disorder, to the pathophysiology of the degenerative process, or to the reparative phenomena with the aim of preventing the cause, slowing or attenuating the progression or reinforcing the function of compensatory neuronal circuitries. Metabotropic glutamate receptors may be considered as a potential target for drugs aimed at reducing the progression of neuronal degeneration
ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS PREVENTS NEURONAL APOPTOSIS IN CULTURE
No full textCultured granule cells grown in serum-containing medium with a ''low K+'' concentration (10 mM) underwent apoptosis after maturation for 5 days in vitro (5 DIV), a time that coincides with the developmental decline in the activity of metabotropic glutamate receptors (mGluRs) coupled to polyphosphoinositide hydrolysis. The mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) prevented the development of low K+-induced apoptosis and the presence of the drug was critical at 6 and 7 DIV, i.e., after the drop of mGluR activity. The neuroprotective action of 1S,3R-ACPD was prevented by the mGluR antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) and was mimicked by N-methyl-D-aspartate or carbamylcholine but not by agonists of the mGluR subtypes negatively linked to adenylyl cyclase. In cultures treated either with Li+-which reduced polyphosphoinositide response to concentrations of glutamate (5 mu M) that approximate those physiologically present in the incubation medium-or MCPG, the development of low K+-induced apoptosis already occurred at 4 DIV. Thus, the activation of mGluRs coupled to polyphosphoinositide hydrolysis by endogenous glutamate could contribute to protect cultured granule cells against apoptosis during early stages of maturation
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons
No full text- …
