41 research outputs found
Supplemental material 2 for Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial
No full textSupplemental material 2 for Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial by Mukul Sharma, Robert G Hart, Eric E Smith, Jackie Bosch, Fei Yuan, Amparo Casanova, John W Eikelboom, Stuart J Connolly, Gloria Wong, Rafael Diaz, Patricio Lopez-Jaramillo, Georg Ertl, Stefan Störk, Gilles R Dagenais, Eva M Lonn, Lars Ryden, Andrew M Tonkin, John D Varigos, Deepak L Bhatt, Kelley RH Branch, Jeffrey L Probstfield, Jae-Hyung Kim, Jong-Won Ha, Martin O’Donnell, Dragos Vinereanu, Keith AA Fox, Yan Liang, Lisheng Liu, Jun Zhu, Nana Pogosova, Aldo P Maggioni, Alvaro Avezum, Leopoldo S Piegas, Katalin Keltai, Matyas Keltai, Nancy Cook Bruns, Scott Berkowitz and Salim Yusuf in International Journal of Stroke</p
Supplemental material 1 for Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial
No full textSupplemental material 1 for Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial by Mukul Sharma, Robert G Hart, Eric E Smith, Jackie Bosch, Fei Yuan, Amparo Casanova, John W Eikelboom, Stuart J Connolly, Gloria Wong, Rafael Diaz, Patricio Lopez-Jaramillo, Georg Ertl, Stefan Störk, Gilles R Dagenais, Eva M Lonn, Lars Ryden, Andrew M Tonkin, John D Varigos, Deepak L Bhatt, Kelley RH Branch, Jeffrey L Probstfield, Jae-Hyung Kim, Jong-Won Ha, Martin O’Donnell, Dragos Vinereanu, Keith AA Fox, Yan Liang, Lisheng Liu, Jun Zhu, Nana Pogosova, Aldo P Maggioni, Alvaro Avezum, Leopoldo S Piegas, Katalin Keltai, Matyas Keltai, Nancy Cook Bruns, Scott Berkowitz and Salim Yusuf in International Journal of Stroke</p
Private sector approaches to effective family planning
No full textEven if per-user costs are controlled or reduced, the rising demand for family planning services will far outstrip governments'and donors'financial resources in most parts of the developing world. This"resource gap"lies at the heart of donor-sponsored initiatives to involve the private sector in family planning, but there are other equally good arguments for doing so. Governments and donors are often unaware of how much the private sector (especially the commerical sector) already participates - and could participate - in family planning. The author discusses why the private sector should be involved in planning, how the private sector should be defined, what the experience has been so far with private sector involvement, and what might be expected in the future. To support family planning in the private sector, the author recommends that donors: (1) expand the total family planning market to help satisfy existing and future unmet needs for contraception; and (2) shift current users from subsidized to more nearly self-supporting outlets - without compromising coverage, equity, or quality of care. The kinds of private sector activities that donors should support depend in part on which contraceptive methods are to be emphasized. Nonclinical systems, for example, are the most efficient way to distribute supply methods (for example, oral contraceptives and condoms), as long as medical backup is available for women who suffer side effects or who wish to switch to another method. These systems of distribution free up scarce resources in clinical facilities and the time of limited medical personnel for the resupply of contraceptives. However, if sterilization is to be emphasized, a close link with existing hospital infrastructure is necessary. Nonclinical distribution favors commercial systems in urban and periurban settings and community-based distribution systems (either public or private) where commercial networks break down. Price subsidies might be considered in areas served by commercial systems, but where consumers cannot afford prevailing commercial prices. The author discusses a wide range of experiences in providing both"supply"methods and clinical methods, such as sterilization (including tubal ligation). Roving sterilization camps have proved effective in Nepal and Thailand, for example, where demand for the procedure was high; they may have backfired in other areas, such as India. Mobile clinic vans have been tried in such countries as Colombia andGuatemala, but their effectiveness and cost-efficiency have not been carefully analyzed. Among the topics the author covers: when to subsidize goods and services, when to introduce new subsidized nongovernmental organization outlets, which regulations may inhibit the expansion of private family planning efforts, how to foster demand for private sector family planning goods and services, and how to promote the private supply of such goods and services.Health Monitoring&Evaluation,Agricultural Knowledge&Information Systems,Health Economics&Finance,Gender and Health,Adolescent Health
Cioran’s ‘grain of ataraxy’ : boredom, nothingness, and quietism
No full textIn reading E.M. Cioran’s œuvre, one is faced with an immediate and unremitting abrasiveness that has its roots with our being born into time. Indeed, the author of The Fall into Time and The Trouble with Being Born thought that it is precisely this accidental and unredeemable temporality, an original sin that results in a life forever situated in cycles of striving and becoming, which is to be exhuastingly apprehended in the experience of boredom: ‘Life is more and less than boredom, though it is in boredom and by boredom that we discern what life is worth.’ Cioran’s pessimism never relents; even his lugubrious friend Samuel Beckett had to keep a distance after finding him ‘too pessimistic’—who else but Cioran could write that ‘leukemia is the garden where God blooms’? Despite this, in Cioran’s often autobiographical, aphoristic and essayistic writings, we find a richly-timbred boredom (ironically so) which gives us incisive observations into a multitude of related concepts and realities. Nothingness, God, silence, mysticism, suffering, and quietism (among others) all feature in Cioran’s writings on boredom, as well as in this paper’s attempt to better situate Cioran’s work with respect to his more famous pessimistic and existentialist relations’s take on the subject, namely Arthur Schopenhauer and Martin Heidegger. In exploring his work on boredom vis-à-vis his specific interest in mysticism, Taoism, nothingness, time and insomnia, this paper aims to show how the failure to attain what Cioran called ‘a grain of ataraxy’, necessarily presupposes a limited set of ‘possibilities’ and ‘prospects’ when faced with the experience of ‘the sensation of the emptiness of existence’ that is boredom (Schopenhauer).peer-reviewe
JAEPL, Vol. 9, Winter 2003-2004
No full textEssays
Kilian McCurrie. Spiritual Identities, Teacher Identities, and the Teaching of Writing. Through a case study, this article examines the ways teacher identity and spiritual identity intersect in the teaching of writing. By showing that a teacher\u27s pedagogy is prodoundly informed by a basic spiritual disposition, the author offers a view of teaching that is often neglected in studies of teacher identity.
Robert Root. The Experimental Art. Nonfiction is an experimental art, as contemporary examples make clear, and writing teachers need to show students both how meaning arises from writers\u27 experiments with material and also how form from writers\u27 experiements at representing meaning.
Candance Walworth. Engaged Buddhism & Women in Black: Our Grief Is Not a Cry for War. This paper explores principles, practices, and manifestations of engaged Busshism in the United States. It includes a personal narrative based on the author\u27s participation in Women in Black (a silent, symbolic protest against war) and classroom stories based on the author\u27s experience teaching at a Buddhist-inspired university.
Laura Milner. Compos(t)ing Loss: Transformation in the Telling. Using composting as a metaphor, this author examines the transformative protential in writing about and bearing witness to stories of loss, particularly the death of a parent.
Cristina Vischer Bruns. Encounters: Relationship in the Study and Teaching of Literature. While trends in the teaching of literature of the last few decades may seem at odds with one another, the thread that can weave them together is a recognition of relationship among readers, text, author, and other readers.
Kia Jane Richmond. An Unspoken Trust—Violated. Reflecting on our decisions in the classroom, both when we are honest with our students & when we are not, can offer teachers opportunities for growth and change.
Carolyn L. Piazza and Christine Jecko. Multiple Forms of Prewriting in Elementary Writing Literature. Multisensory prewriting invitations (creative visualizations, art, music, dreams, and mediations) affect writing fluency and idea generation in the first draft writing of elementary students. W. Keith Duffy. Community, Spirituality, and the Writing Classroom. From a spiritual perspective, this article critiques the concept of community as defined by scholars of rhetoric and composition; the author suggests that our experience of community in the writing classroom cab be enhanced if we strike a balance between doing and being.
Helen Walker. Connecting. Jim Super—Fearless
Pamela Hartman—English? I\u27d Rather Read A Book
Nancy Myers—B
Andrea Siegel—Walking the Talk, Breathing the Breath
Traci L. Merritt—The Day Jenny Died
Susan A. Schiller—Touched by the Spirit in AEPL Topics
Wilma Romatz—On the Delicate Art of Teaching Reviews
Dale Jacobs. The Energy to Teach (Donald H. Graves, 2001)
Stan Scott. Writing with Elbow (Pat Belanodd, 2002)
Sue Hum. Unfolding Bodymind (Brent Hocking, Johnna Haskell, Warren Linds, 2001)
Lita Kurth. The Unconscious (Athony Easthope, 1999
Iowa History and Culture : A Bibliography of Materials Published Between 1952 and 1986, 1989
No full textThis bibliography was compiled by two reference librarians, Patricia Dawson and David Hudson with the goal of making it easier of tracking down material on Iowa history and culture. This supplements the Iowa History Reference Guide published in 1952 by William Petersen
Addressing the cyber safety challenge: from risk to resilience
No full textAddressing the cyber safety challenge: from risk to resilience describes the cyber safety issues emerging from a range of technology trends, how different populations are using technologies and the risks they face, and how we can effectively respond to each group’s unique cyber safety needs.
Written by the University of Western Sydney for Telstra Corporation Ltd, the report advocates for continuing to move cyber safety from a ‘risk and protection’ framework to one that focuses on building digital resilience, as well as fostering trust and confidence in the online environment. To do this we need to:
Address the needs of populations often neglected by current policies and programs – including adults, seniors, parents, and small to medium enterprises
Continue to build the digital literacy skills of all populations, because digital literacy strongly influences users’ ability to engage safely online – this is best achieved by a hands-on learning approach
Keep risk in perspective – the risks and benefits of digital participation go hand in hand
Broaden the focus from awareness-raising to long-term behaviour change.
As digital technologies become further integrated into the everyday lives of Australians, users are potentially exposed to greater risks. However, the risks and benefits of digital participation go hand in hand. The challenge, therefore, is to support users to minimise the risks without limiting their digital participation and their capacity to derive the full benefits of connectivity. If Australians are to benefit as either consumers or providers of online services and products in the e-commerce environment, consumer safety and trust need to be improved.
Cyber safety needs to be considered against a transforming backdrop of technology trends, products and practices. While the rise of social media has tended to dominate recent debate and developments in cyber safety, particularly in relation to young people, a range of other trends is also shaping how users engage online, the risks they potentially face in the new media landscape, and the strategies used to address them. These trends include the rise of user generated content and content sharing platforms; the uptake of mobile technologies and, in particular, the adoption of smartphones; cloud computing; platform integration and single sign-on mechanisms; and the rise of GPS and location based services
Stroke Outcomes in the COMPASS Trial
No full textBACKGROUND: Strokes were significantly reduced by the combination of rivaroxaban plus aspirin in comparison with aspirin in the COMPASS trial (Cardiovascular Outcomes for People Using Anticoagulation Strategies). We present detailed analyses of stroke by type, predictors, and antithrombotic effects in key subgroups.
METHODS: Participants had stable coronary artery or peripheral artery disease and were randomly assigned to receive aspirin 100 mg once daily (n=9126), rivaroxaban 5 mg twice daily (n=9117), or rivaroxaban 2.5 mg twice daily plus aspirin (n=9152). Patients who required anticoagulation or had a stroke within 1 month, previous lacunar stroke, or intracerebral hemorrhage were excluded.
RESULTS: During a mean follow-up of 23 months, fewer patients had strokes in the rivaroxaban plus aspirin group than in the aspirin group (83 [0.9% per year] versus 142 [1.6% per year]; hazard ratio [HR], 0.58; 95% CI, 0.44-0.76; P<0.0001). Ischemic/uncertain strokes were reduced by nearly half (68 [0.7% per year] versus 132 [1.4% per year]; HR, 0.51; 95% CI, 0.38-0.68; P<0.0001) by the combination in comparison with aspirin. No significant difference was noted in the occurrence of stroke in the rivaroxaban alone group in comparison with aspirin: annualized rate of 0.7% (HR, 0.82; 95% CI, 0.65-1.05). The occurrence of fatal and disabling stroke (modified Rankin Scale, 3-6) was decreased by the combination (32 [0.3% per year] versus 55 [0.6% per year]; HR, 0.58; 95% CI, 0.37-0.89; P=0.01). Independent predictors of stroke were prior stroke, hypertension, systolic blood pressure at baseline, age, diabetes mellitus, and Asian ethnicity. Prior stroke was the strongest predictor of incident stroke (HR, 3.63; 95% CI, 2.65-4.97; P<0.0001) and was associated with a 3.4% per year rate of stroke recurrence on aspirin. The effect of the combination in comparison with aspirin was consistent across subgroups with high stroke risk, including those with prior stroke.
CONCLUSIONS: Low-dose rivaroxaban plus aspirin is an important new antithrombotic option for primary and secondary stroke prevention in patients with clinical atherosclerosis.
CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01776424.restrictio
Agents with vasodilator properties in acute heart failure: how to design successful trials
No full textAgents with vasodilator properties (AVDs) are frequently used in the treatment of acute heart failure (AHF). AVDs rapidly reduce preload and afterload, improve left ventricle to aorta and right ventricle to pulmonary artery coupling, and may improve symptoms. Early biomarker changes after AVD administration have suggested potentially beneficial effects on cardiac stretch, vascular tone, and renal function. AVDs that reduce haemodynamic congestion without causing hypoperfusion might be effective in preventing worsening organ dysfunction. Existing AVDs have been associated with different results on outcomes in randomized clinical trials, and observational studies have suggested that AVDs may be associated with a clinical outcome benefit. Lessons have been learned from past AVD trials in AHF regarding preventing hypotension, selecting the optimal endpoint, refining dyspnoea measurements, and achieving early randomization and treatment initiation. These lessons have been applied to the design of ongoing pivotal clinical trials, which aim to ascertain if AVDs improve clinical outcomes. The developing body of evidence suggests that AVDs may be a clinically effective therapy to reduce symptoms, but more importantly to prevent end-organ damage and improve clinical outcomes for specific patients with AHF. The results of ongoing trials will provide more clarity on the role of AVDs in the treatment of AHF
Silence and the crisis of self - legitimation in English romanticism
No full textMy thesis depicts the crisis of self-legitimation that has accompanied the onset of modern hermeneutics, with its historicised and organicised version of the Enlightenment's 'universal perspective.' In this it follows the lead of the contemporary hermeneuticist Hans- Georg Gadamer in resuscitating the notion of prejudice, but contrasts it with Hannah Arendt's discussion of the human condition. She implicitly locates the problem in modern hermeneutics, the aporia, in the very philosophy of life that Gadamer embraces as its solution. Gadamer confuses the task of the humanities as a search for truth with what it ought to be, a search for meaning. I begin with his depiction of Kant's attack on the sensus communis; I conclude with an examination of the consequences of this attack on the orientation and interpretative practices of current schools of literary criticism with specific reference to Keats's Ode on a Grecian Urn. In the central chapter, I focus upon Coleridge's attack on Wordsworth's Preface to Lyrical Ballads (1802) in the Bioeraphia Literaria, reading it as a fundamental defence of prejudice based on the very fact that man has been made in imago Dei. The consequent logocentricity of humanity that Coleridge insists upon opposes Wordsworth's emphasis upon a transcendental idea of 'feeling.' This fundamental notion forms the basis of Coleridge's definition of the primary imagination. I argue the distinctiveness of his definition from that of the other Romantics and maintain its necessity to escape the aporia. This point is proved negatively by Shelley's Mont Blanc, which seizes upon the radical consequences of Wordsworth's poetics, presenting both heresy and obscurity in the poem. The word 'crisis' thus reflects the urgency with which I advocate the need to re-adopt Coleridge's emphases in contemporary literary criticism
