518 research outputs found
Dynamics of the human pelvis: Identification methodology for low back pain diagnosis
No full textThis project finds its justification in the vast economic and social impact that musculoskeletal disorders have at a global level. Many cases of low back pain, which is the most relevant disorder among them, remain a mystery as far as their pathology is concerned. The assumption underlying this work is that, for those mysterious cases, the problem is located in the sacroiliac joints of the pelvic girdle in form of abnormal biomechanical properties. Unfortunately, at present there is no diagnostic means to assess those properties in an objective manner. The goal of this project is thus to develop a diagnostic tool for an objective non-invasive estimation of the biomechanical properties of the sacroiliac joints in those cases of inexplicable low back pain. The idea behind it is to perform a system identification, with the pelvis being the "system", based on dynamic testing of the pelvic structure in vivo. In order to do this an identification methodology is necessary, based on a dynamic model of the pelvis, as well as an apparatus for the detection of the dynamic response of the pelvis in vivo. In this work this methodology has been investigated, with focus on the model and the identification tools. The development of the apparatus is only briefly described, since it was the subject of a parallel PhD track.Mechanical Maritime and Materials Engineerin
Problem periodyzacji literatury łacińskiej doby cesarstwa rzymskiego (I–II wiek n.e.)
No full textThe article deals with the problem of periodization of Latin literature at the time of the Roman Empire, especially in the first two centuries AD. Having assumed the cyclical nature of phenomena in the field of culture and literature, the author proposes to identify three successive historical-literary phases: [a] the early-imperial period (14–68 AD); [b] the Flavian or liberal period (69–117 AD); [c] the archaizing or Frontonian period (117–192 AD). The scrupulous analysis of the epic, lyric and dramatic works, written in Latin in the first and second centuries AD, clearly documents that the individual literary periods stand in clear opposition to the preceding and following phases. They contain dominant trends, current movements and literary phenomena, distinct from the ones which precede and follow. Ten main differences or similarities between the historical-literary periods are carefully presented in three attached tables (Nos. 1–3).Artykuł podejmuje problem periodyzacji literatury rzymskiej doby cesarstwa rzymskiego, skupiając się na dwóch pierwszych wiekach n.e. Autor, zakładając cykliczność zjawisk w dziedzinie kultury i literatury, proponuje wydzielenie trzech faz historycznoliterackich: [a] okres wczesnoimperialny (14–68 n.e.); [b] okres flawiański lub liberalny (69–117 n.e.); [c] okres archaizujący lub frontoniański (117–192 n.e.). Skrupulatna analiza dzieł epickich, lirycznych i dramatycznych, napisanych po łacinie w pierwszym i drugim stuleciu n.e., jasno dokumentuje że wyróżnione okresy literackie stoją w wyraźnej opozycji do faz poprzedzających i po nich następujących. Występują w nich dominujące prądy i zjawiska literackie, odmienne niż w fazie poprzedzającej i bezpośrednio po nich następującej. Trzy załączone tabele prezentują dziesiątkę głównych odrębności lub podobieństw pomiędzy trzema analizowanymi okresami literarckimi
Diocensis Ponticae habet provincias numero VII – uwagi o monografii diecezji Pontu w IV–VII wieku n.e.
No full textThe reviewing article is dedicated to the monograph by Łukasz Smorczewski, Administracja diecezji Pontu w późnym Cesarstwie Rzymskim, Poznań 2019, issued as a 2nd volume of the series “Bibliotheca Classica et Byzantina.” The book by Smorczewski describes the history of Pontus dioecesis in the late Roman Empire from its creation at the beginning of the 4th century till the emergence of a thematic system. The author discusses the problems of shaping the dioecesis in the 4th century, its internal structure, as well as the competences of the head of this territorial unit: the vicar. The author offers a good description of the scientific discussion of the problems connected to that territorial unit of the Empire. An important part of the Smorczewski\u27s monograph is played by prosopographical studies, placed at the end of this book.Artykuł recenzyjny jest poświęcony monografii Łukasza Smorczewskiego, Administracja diecezji Pontu w późnym Cesarstwie Rzymskim, Poznań 2019 wydanej jako drugi tom serii „Bibliotheca Classica et Byzantina”. Książka Smorczewskiego przedstawia historię diecezji Pontu w czasach późnego Cesarstwa Rzymskiego od jej powstania w początkach IV wieku n.e. do pojawienia się systemu temowego. Autor rozważa problemy kształtowania się diecezji w IV wieku n.e., jej strukturę wewnętrzną, a także kompetencje jej zwierzchnika – wikariusza, jak również ukazuje dyskusję naukową na temat tej jednostki terytorialnej cesarstwa. Istotną rolę w monografii Smorczewskiego odgrywają badania prozopograficzne umieszczone na końcu książki
An essay to do good. [electronic resource] : By a disswasive from tavern-haunting, and excessive drinking. By Benjamin Wadworth, Pastor of a church of Christ in Boston; together with a lecture sermon, by the same author.
No full textCaption title.Running title: A disswasive from excessive drinking.Imprint from colophon, p. 44. A colophon on p. 22 reads: Read this essay and give it to thy neighbour. Boston, N.E. January, 25th. 1709,10."The all-seeing eye of God our judge should restrain us from sin, and quicken us to duty; urg'd in a lecture-sermon, preached at Boston, N.E. December 22. 1709."--p. 23-44. Running title: Gods eye should restrain us from sin, and quicken us to duty.Signatures: Ap6s(-1 leaf) B-Dp6s (D6 blank). - SHOULD SIGNATURE A1 HAVE 6 LEAVES? TITLE PAGE?Evans,Electronic reproduction.English Short Title Catalog,Reproduction of original from Boston Public Library
The Diffusion of Bt Cotton and the Economic Impact on Producers
No full textThe objective is to present the economic impact of producers adopting Bt cotton and the rapid diffusion on the main producing countries: USA, China and India. The existing literature about this type of transgenic crop has been revised and the results of different research are presented. Bt cotton varieties have been quickly adopted by the countries in this study. Data show that this technology helps reduce production losses and significantly decrease the use of pesticides, thus saving their cost and the associated labour cost. But the total cost reduction is weak due to the high prices of the seeds incorporating this technology.Innovation diffusion, Bt cotton, Crop Production/Industries,
Reinterpreted Facsimile: N.E. Thing Co. Ltd. Companies Act (2020)
No full textThis thesis questions the definition of facsimile pertaining to artist’s books and examines what information gets lost by adhering to it when remaking culturally significant texts. The primary case study is the physical republishing of Companies Act (1978), by the N.E. Thing Company — a rare book that summarizes a historically influential Canadian conceptual art duo. The aim of this thesis is to clarify the methodology and process used to reproduce this book and draw attention to its associated implications toward the field of print design. The standard logic of reprinting a manuscript generally follows the idea of facsimile reproduction, which is described by leading publishing authorities like Manfred Kramer as reproducing manuscripts as close to the original as possible. The aim of this thesis project is to expand on this concept by proposing the concept of a reinterpreted facsimile that adds contextual elements to the republished manuscript that would not exist otherwise. The case studies throughout this thesis have found that in at least this particular instance, Kramer’s goal of exact verisimilitude has many shortcomings. The conclusion of my work explores and defines the idea of a reinterpreted facsimile that productively blurs the line between art and print design.Print designNETCOPublishingReinterpreted facimil
March Of Medicine
No full textDistribution Of First Lesions In Leprosy. Horton,R.J. & Povey, S
Chronic Ill Health From Unrecognised Malaria. Wills, N.E., Turner,P.P. , Somers, K. & Markandya, O.P.
Infant Mortality Due To Congenital Malformations. Landtman, B. and Wallgren, E.
A single-cell study on stochasticity growth and gene expression
No full textLife of single cells is not deterministic, but virtually all processes in a cell are subject to stochastic fluctuations. As consequence, genetically identical cells, which are living in the same environment, can behave differently. They can, for example, produce different amounts of proteins, grow at different rates and can even specialize into completely different phenotypes. The discovery of cell-to-cell variability opened up many questions, ranging from what are the origins of the fluctuations, to whether its consequences are detrimental or beneficial for cells.The aim of this thesis is to better understand stochasticity in gene expression and growth rate of bacterial cells. To this end, we investigate whether, next to gene expression, also growth rate of single cells fluctuates dynamically, which we will show to be the case. We then focus on the following questions about gene expression and growth: What are the origins of fluctuations? Can fluctuations propagate from one to the other? To address these questions, we work with a model organism, the bacteriumE. coli . This organism is simple enough to allow for quantitative experiments, but already so complex that many processes inside these cells have not been understood yet.Studying stochastic fluctuations in gene expression and growth rate in single cells requires precise and rather high throughput tools to measure these quantities. In chapter 2 and 3 we describe these methods. By using automated time-lapse microscopy, we acquire movies of growing E. coli cells which are expressing fluorescent proteins. We then use automated analysis software to segment, track and analyze cells. To accurately measure gene expression, a fluorescent protein reporter of high quality is needed. Therefore, we present a comparison of different fluorescent proteins which assesses their suitability for time-lapse experiments.In chapter 4 we investigate the general interdependence of fluctuations in gene expression and growth rate. We find that the noise intensities of both fluctuations are very strongly correlated and that they scale linearly. In apparent contrast to that, the fluctuating time traces are shown to be only modestly correlated. We develop a linear noise model to explain these observations and analyze what constraints the linear scaling imposes on such models. A central result is that the intensities of different cellular noise sources do not change independently, but are set by one single global parameter.In chapter 5 we study the effects of a specific source of fluctuations in gene expression: the bacterial cell cycle. As cells grow and prepare for division, they copy their chromosome. With two copies of each gene and an increasing cell size, the production rate of proteins increases. We show that about half of the noise in protein production rate is caused by gene duplication. In contrast to that, protein concentration is hardly affected by the cell cycle because the exponential volume increase almost perfectly cancels the increase in protein production rate.The fact that gene expression fluctuates has been known for many years. However, it was unclear whether such fluctuations also affect the growth rate of cells. This question is addressed in chapter 6. We show that fluctuations in enzymes can indeed propagate and cause growth fluctuations. Conversely, growth fluctuations also propagate back to disturb protein concentration. We develop an analytical model to accurately predict noise transmission. Our results indicate that fluctuations can not only propagate through gene networks but also through metabolic reactions. They also suggest that cellular metabolism is inherently stochastic.Finally, in chapter 7 we investigate the influence of fluctuations in ribosome concentration on the growth rate. Because ribosomes are the molecular machines responsible for protein production, they play a central role in cellular growth. Each cell needs thousands of ribosomes and as producing these large numbers is costly, the ribosome production is tightly regulated and adjusted to the need. Still, their concentration in single cells fluctuates, and we here investigate whether these fluctuations affect growth rate. Our data suggests that fluctuations in ribosome concentration do not propagate to growth, which indicates that ribosomes are not dynamically limiting growth rate.BN/Sander Tans La
A multi-parameter approach to fingerprinting suspended-sediment sources
No full textSelection of fingerprinting properties or tracers with contrasting behaviour was used to assist in discriminating between several potential sources and in providing more definitive and reliable results. Examples of a multi-parameter approach to fingerprinting suspended sediment source in two small catchments in Devon, United Kingdom, are presented. -from Author
A multi-parameter approach to fingerprinting suspended-sediment sources
No full textSelection of fingerprinting properties or tracers with contrasting behaviour was used to assist in discriminating between several potential sources and in providing more definitive and reliable results. Examples of a multi-parameter approach to fingerprinting suspended sediment source in two small catchments in Devon, United Kingdom, are presented. -from Author
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