104,298 research outputs found
La filologia di Contini. Guida alla lettura
No full textCommento e aggiornamento del saggio di Gianfranco Contini sul metodo filologico
Gianfranco Contini e Pietro Ciapessoni. Un alunno d'eccezione, un rettore lungimirante
No full textSull’epistolario inedito di G. Contini studente a Pavia con Pietro Ciapessoni, rettore del collegio universitario "Ghislieri"
Difficult diagnosis of infliximab-related miliary tuberculosis
No full textDifficult diagnosis of Infliximab-related miliary tuberculosis. S. Contini, G. Raimondi, P. Graziano, C. Saltini, M. Bocchino. The use of Infliximab in the treatment of patients with rheumatoid diseases unresponsive to conventional therapies has been reported to be complicated by opportunistic infections. We report the case of a 56-yr old female rheumatoid arthritis patient complaining of fever and respiratory symptoms 9 months after commencing Infliximab, who received no ethiologic diagnosis for the six months before admission. Tuberculosis was suspected upon chest radiographic pictures and empirical treatment for miliary tuberculosis instated in the wake of microbiological confirmation. The case typifies the difficulties of diagnosing miliary tuberculosis in the immunocompromised as well as in the immunocompetent patient
Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934
No full textContini Gianfranco. Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934. In: Romania, tome 62 n°245, 1936. pp. 119-121
Avvertenza editoriale
No full textStoria editoriale della raccolta di scritti, progettata da G. Contini e uscita postuma a cura di G. Breschi
Alle origini delle dimostrazioni italiane del 1 maggio
No full textL'avvio del movimento operaio in Italia si accompagna con un'abbondante produzione o rielaborazione di forme espressive, che presto si definiscono come i primi linguaggi di mass
La morte ai tempi dei social: culture e attori della partecipazione
No full textIl volume affronta, secondo la prospettiva sociologica, il tema della morte.
Il particolare momento storico favorisce la riflessione su questa dimensione, tornata prepotentemente alla ribalta.
I contributi degli autori intendono inquadrare teoricamente il fenomeno, per poi osservarlo da specifici punti di vista: il rapporto con la morte e con i dolenti nelle relazioni di cura, la “morte dei migranti”, la morte al tempo dei social media e la dimensione rituale della morte.
La morte non è solo un fatto biologico, ma è una esperienza che presenta delle sostanziali interconnessioni con le rappresentazioni socioculturali caratteristiche dell’hic et nunc di ogni società, e come tale è stata studiata
HLA-G in Allergy: Does It Play an Immunoregulatory Role?
No full textAllergy is an inflammatory process determined by a cascade of immune events characterized by T-helper 2 lymphocytes polarization leading to interleukin-4 upregulation, IgE secretion, and mast cell and eosinophil activation. HLA-G molecules, both in membrane-bound and in soluble forms, are known to play a key immunoregulatory role and their involvement in allergic diseases is supported by increasing literature data. HLA-G expression and secretion is specifically induced in peripheral blood mononuclear cells of allergic patients after in vitro incubation with the causal allergen. Elevated levels of soluble HLA-G molecules are detected in serum of patients with allergic rhinitis correlating with allergen-specific IgE levels, clinical severity, drug consumption and response to allergen-specific immunotherapy. HLA-G genetic polymorphisms confer susceptibility to allergic asthma development and high levels of soluble HLA-G molecules are found in plasma and bronchoalveolar lavage fluid of patients with allergic asthma correlating with allergen-specific IgE levels. Interestingly, allergic pregnant women have lower plasma sHLA-G levels than non-allergic women during the 3rd trimester of pregnancy and at delivery. Finally, in allergic patients with atopic dermatitis HLA-G molecules are expressed by T cells, monocytes-macrophages and Langerhans cells infiltrating the dermis. Although at present is difficult to completely define the role of HLA-G molecules in allergic diseases, it may be suggested that they are specifically expressed and secreted by immune cells during the allergic reaction in an attempt to suppress allergic inflammation
HLA-G Expressing Immune Cells in Immune Mediated Diseases
No full textHLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with physiologic conditions. Quantitative and qualitative derangements of HLA-G+ immune cells have been detected in several conditions in which the immune system plays an important role, such as infectious, neoplastic, and autoimmune diseases as well as in complications from transplants and pregnancy. These observations strongly support the hypothesis that HLA-G+ immune cells may be implicated in the complex mechanisms underlying the pathogenesis of these disorders
Evaluation of membrane-bound and soluble forms of human leucocyte antigen-G in systemic sclerosis
No full textSystemic sclerosis (SSc) is a complex disease characterized by immune dysregulation, extensive vascular damage and widespread fibrosis. Human leucocyte antigen-G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by complex immunomodulating properties. HLA-G is expressed on the membrane of different cell lineages in both physiological and pathological conditions. HLA-G is also detectable in soluble form (sHLA-G) deriving from the shedding of surface isoforms (sHLA-G1) or the secretion of soluble isoforms (HLA-G5). Several immunosuppressive functions have been attributed to both membrane-bound and soluble HLA-G molecules. The plasma levels of sHLA-G were higher in SSc patients (444·27 ± 304·84 U/ml) compared to controls (16·74 ± 20·58 U/ml) (P < 0·0001). The plasma levels of transforming growth factor (TGF)-β were higher in SSc patients (18 937 ± 15 217 pg/ml) compared to controls (11 099 ± 6081 pg/ml; P = 0·003), and a significant correlation was found between TGF-β and the plasma levels of total sHLA-G (r = 0·65; P < 0·01), sHLA-G1 (r = 0·60; P = 0·003) and HLA-G5 (r = 0·47; P = 0·02). The percentage of HLA-G-positive monocytes (0·98 ± 1·72), CD4+ (0·37 ± 0·68), CD8+ (2·05 ± 3·74) and CD4+ CD8+ double-positive cells (14·53 ± 16·88) was higher in SSc patients than in controls (0·11 ± 0·08, 0·01 ± 0·01, 0·01 ± 0·01 and 0·39 ± 0·40, respectively) (P < 0·0001). These data indicate that in SSc the secretion and/or shedding of soluble HLA-G molecules and the membrane expression of HLA-G by peripheral blood mononuclear cells (PBMC) is clearly elevated, suggesting an involvement of HLA-G molecules in the immune dysregulation of SSc
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