1,720,995 research outputs found
T-cell lymphomas: where we are and where we a re moving forward
No full textMature T-Cell Lymphomas (PTCLs) represent a heterogeneous group of haematological malignancies, with a fairly poor outcome. Due to their rarity, PTCLs are very poorly understood and information useful to develop more rational therapeutic approaches and substantially improve the prognosis are limited.
The T-Cell Project (TCP), launched a prospective collection of accurate data coming from patients with newly diagnosed PTCLs, with the aim of improving knowledge on these rare diseases. From Sept 2006 to Jan 2016, 1,439 cases have been registered by 74 Institutions world-wide. PTCL-NOS emerged as the most frequent subtype (36%). Combination chemotherapy was the preferred approach (90%), anthracycline-containing regimens being the favourite (84%). Consolidative ASCT was reported in 7%, with different geographic distribution. After induction therapy 54% achieved a CR and 18% a PR. After a median follow-up of 35 months, 5-yr OS and PFS were 44% and 33%, respectively. The ALCL, ALK+ showed the best 5-yr OS (73%).
The TCP is the largest ongoing prospective registry; and is now moving forward to the establishment of a large biorepository. This exceptional position could allow to build future treatment platforms predicated on our biological understanding of the disease, which we anticipate will lead to the development of subtype specific treatments
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Chemotherapy infusion for cancer patients with the assistance of immersive virtual reality (IVR): a scoping review of the literature
Full text linkPurpose: To summarize scientific findings related to cancer patients undergoing chemotherapy infusions assisted by Immersive Virtual Reality (IVR). The study focused on the involvement of nurses, the sole healthcare professionals authorized to administer the chemotherapy infusion, and evaluated the extent to which IVR helped reduce anxiety and distress. Method: To conduct this review, various databases, including Medline (via Pubmed), Web of Science (WoS), CINAHL, Scopus, and Google Scholar were searched. The PRISMA guidelines were followed in accordance with the EQUATOR checklist. Results: Relevant articles were identified by searching for studies that explored the use of IVR to support cancer patients undergoing chemotherapy infusions, assessed their perceived anxiety and stress levels, and discussed the role of nurses in this context. A total of 23 papers were included in the review. Conclusions: Most of these studies indicated that using IVR to distract patients during chemotherapy infusions led to a reduction in anxiety and distress levels. This not only facilitated the nursing care process but also improved the patient's compliance with the therapy regimen
The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project
No full textPeripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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