1,720,986 research outputs found
A NEW METHOD TO SCREEN CLONES FROM DIFFERENTIAL DISPLAY EXPERIMENTS PRIOR TO RNA STUDIES
No full textZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulating Hes5 Gene Expression
Full text linkZinc finger protein 423 encodes a 30 Zn-finger transcription factor involved in cerebellar and olfactory development. ZFP423 is a known interactor of SMAD1-SMAD4 and of Collier/Olf-1/EBF proteins, and acts as a modifier of retinoic acid-induced differentiation. In the present article, we show that ZFP423 interacts with the Notch1 intracellular domain in mammalian cell lines and in Xenopus neurula embryos, to activate the expression of the Notch1 target Hes5/ESR1. This effect is antagonized by EBF transcription factors, both in cultured cells and in Xenopus embryos, and amplified in vitro by BMP4, suggesting that ZFP423 acts to integrate BMP and Notch signaling, selectively promoting their convergence onto the Hes5 gene promoter
The human skeletal muscle glycogenin gene: cDNA, tissue expression and chromosomal localization
No full textImmunohistochemical and genetic characterization of the M Cagliari alpha-1-antitrypsin molecule (M-like alpha-1-antitrypsin deficiency)
No full textcDNA sequence, map and expression of the murine homolog of GTBP , a DNA mismatch repair gene.
No full textA computer-driven approach to PCR based differential screening, alternative to differential display.
No full textPKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
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Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene
No full textMab 21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development.
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