1,118 research outputs found
A NEW METHOD TO SCREEN CLONES FROM DIFFERENTIAL DISPLAY EXPERIMENTS PRIOR TO RNA STUDIES
No full textZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulating Hes5 Gene Expression
No full textZinc finger protein 423 encodes a 30 Zn-finger transcription factor involved in cerebellar and olfactory development. ZFP423 is a known interactor of SMAD1-SMAD4 and of Collier/Olf-1/EBF proteins, and acts as a modifier of retinoic acid-induced differentiation. In the present article, we show that ZFP423 interacts with the Notch1 intracellular domain in mammalian cell lines and in Xenopus neurula embryos, to activate the expression of the Notch1 target Hes5/ESR1. This effect is antagonized by EBF transcription factors, both in cultured cells and in Xenopus embryos, and amplified in vitro by BMP4, suggesting that ZFP423 acts to integrate BMP and Notch signaling, selectively promoting their convergence onto the Hes5 gene promoter
The human skeletal muscle glycogenin gene: cDNA, tissue expression and chromosomal localization
No full textImmunohistochemical and genetic characterization of the M Cagliari alpha-1-antitrypsin molecule (M-like alpha-1-antitrypsin deficiency)
No full textcDNA sequence, map and expression of the murine homolog of GTBP , a DNA mismatch repair gene.
No full textA computer-driven approach to PCR based differential screening, alternative to differential display.
No full textPKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
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Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth
No full textbarhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS.
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