108 research outputs found
The application of respiratory muscle training to competitive rowing
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Respiratory muscle training (RMT) has been shown to improve exercise tolerance during a wide range of exercise modalities and durations of activity (McConnell & Romer, 2004b). However, there is a limited amount of research characterising the influence of RMT in specific athletic populations, or examining any sport-specific factors that may influence the benefits of RMT. Hence, the purpose of this dissertation was to evaluate the application of RMT in competitive rowers and to explore methods of optimising this to rowing. Results: Inspiratory muscle training (IMT) increased inspiratory muscle strength (~20-29%; p < 0.05) and attenuated inspiratory muscle fatigue (~8-28%; p < 0.05) during time trial performance in club-level and elite rowers. However, only in the club-level oarsmen was IMT associated with a measurable improvement in rowing performance (2.7% increase in mean power; p < 0.05). Expiratory muscle training (EMT) provided no ergogenic effect, and concurrent EMT and IMT did not enhance performance above that seen with IMT alone. IMT loads performed at 60-70% of maximal inspiratory mouth pressure (PImax) were equivalent to the widely used 30 repetition maximum, which is higher than reported for non-rowers (Caine & McConnell, 1998a); further, a load of 60% PImax was sufficient to activate the inspiratory muscle metaboreflex, as evidenced by a time-dependent rise in heart rate (70.1 ± 13.2 to 98.0 ± 22.8 bpm; p < 0.05) and mean arterial blood pressure (92.4 ± 8.5 to 99.7 ± 10.1 mmHg; p < 0.05). Higher and lower inspiratory loads did not activate the metaboreflex. Assessments of flow, pressure and volume in rowing relevant postures revealed no significant impairments, but optimal function occurred in the most upright postures. Conclusions: These data support the application of IMT, but not EMT, in elite and sub-elite rowers, and suggest that a load of 60-70% of PImax provides metaboreflex activation during loading. Further, the data do not support a requirement to undertake IMT in rowing relevant postures
Development of Oxytolerant Salmonella typhimurium Using Radiation Mutation Technology (RMT) for Cancer Therapy
No full textA critical limitation of Salmonella typhimurium (S. typhimurium) as an anti-cancer agent is the loss of their invasive or replicative activities, which results in no or less delivery of anti-cancer agents inside cancer cells in cancer therapy. Here we developed an oxytolerant attenuated Salmonella strain (KST0650) from the parental KST0649 (ΔptsIΔcrr) strain using radiation mutation technology (RMT). The oxytolerant KST0650 strain possessed 20-times higher replication activity in CT26 cancer cells and was less virulent than KST0649. Furthermore, KST0650 migrated effectively into tumor tissues in mice. KST0650 was further equipped with a plasmid harboring a spliced form of the intracellular pro-apoptotic protein sATF6, and the expression of sATF6 was controlled by the radiation-inducible recN promoter. The new strain was named as KST0652, in which sATF6 protein expression was induced in response to radiation in a dose-dependent manner. This strain was effectively delivered inside cancer cells and tumor tissues via the Salmonella type III secretion system (T3SS). In addition, combination treatment with KST0652 and radiation showed a synergistic anti-tumor effect in murine tumor model with complete inhibition of tumor growth and protection against death. In conclusion, we showed that RMT can be used to effectively develop an anti-tumor Salmonella strain for delivering anti-cancer agents inside tumors. © 2020, The Author(s)
RMT and bottom trawl logs from the AAMBER 2 voyage of the Aurora Australis, 1991
No full textProgress Code: completedStatement: The quality of the scanned pages may vary.This dataset contains scanned copies of the RMT and bottom trawl logs from Voyage 6 1990-91 (AAMBER2) of the Aurora Australis. This was primarily a marine science voyage. Surveys of krill, other zooplankton and pelagic fish were taken in Prydz Bay, Antarctica between January and February 1991.<br/><br/>177 midwater trawls were successfully completed at 59 stations.<br/><br/>Midwater fish were sampled using an International Young Gadoid Pelagic Trawl (IYGPT). At each station, hauls were taken at depths of 20-30m, approximately halfway down the water column, and 20-30m above the bottom. At six stations, the lowest sample was duplicated using a light fitted to the net. Where samples were made off the shelf, standard depths of 20-30m, 400m, and 800m were fished.<br/><br/>All hauls were of 30 minutes fishing time. Bottom trawls were made using a 35m headline length otter trawl fitted with 40cm diameter bobbin gear. A 2" mesh cod end liner was used to retain small fish. On both nets, a Simrad trawl surveillance sonar was used
Implications of the Warm Corona and Relativistic Reflection Models for the Soft Excess in Mrk 509
No full textWe present the analysis of the first Nuclear Spectroscopic Telescope Array observations (~220 ks), simultaneous with the last Suzaku observations (~50 ks), of the active galactic nucleus of the bright Seyfert 1 galaxy Mrk 509. The time-averaged spectrum in the 1–79 keV X-ray band is dominated by a power-law continuum (Γ ~ 1.8–1.9), a strong soft excess around 1 keV, and signatures of X-ray reflection in the form of Fe K emission (~6.4 keV), an Fe K absorption edge (~7.1 keV), and a Compton hump due to electron scattering (~20–30 keV). We show that these data can be described by two very different prescriptions for the soft excess: a warm (kT ~ 0.5–1 keV) and optically thick (τ ~ 10–20) Comptonizing corona or a relativistically blurred ionized reflection spectrum from the inner regions of the accretion disk. While these two scenarios cannot be distinguished based on their fit statistics, we argue that the parameters required by the warm corona model are physically incompatible with the conditions of standard coronae. Detailed photoionization calculations show that even in the most favorable conditions, the warm corona should produce strong absorption in the observed spectrum. On the other hand, while the relativistic reflection model provides a satisfactory description of the data, it also requires extreme parameters, such as maximum black hole spin, a very low and compact hot corona, and a very high density for the inner accretion disk. Deeper observations of this source are thus necessary to confirm the presence of relativistic reflection and further understand the nature of its soft excess
Predicting Stock Market Crashes using Urns and the Quantum Lorenz Ordering of Correlation Matrices
No full textBy sampling financial correlation matrices over sliding windows, it has been shown in recent work that the quantum majorization induced partial ordering on this space of correlation matrices known as the "quantum Lorenz ordering" (QLO) can be used to characterize systemic risk by clustering correlation matrices according to their degree centrality on the associated directed graph called the "quantum majorization graph" (QMG). In this work, clusterings of the QMG are used to construct an online Bayesian nonparametric alarm system for the prediction of stock market crashes via the so-called "reinforced urn process" (RUP). To test the efficacy of this modelling methodology we exploit extreme value theory to systematically define stock market crashes by studying the tail of an appropriately fitted generalized pareto distribution (GPD) for stock market drawdowns. This approach identified 13 extreme drawdowns between 1985-2020, for which the RUP was trained from 1986-2005 to predict the 8 extreme drawdowns from 2005-2020. Of the three correlation metrics used to test this approach, the QLO corresponding to the set of upper Tail-Dependence matrices was shown to outperform the others: Pearson's and the Gini correlation. Tail-Dependence was able to predict all 8 crashes with just 5 false alarms over a 12 month time horizon, all 8 with 7 false alarms over an 8 month time horizon, 7 out of 8 with 9 false alarms over a 4 time horizon, and 7 out of 8 with 17 false alarms over a 2 month time horizon. This approach was then tested against the usage of the Log-Periodic Power Law Singularity (LPPLS) model's confidence indicators with promising results. The quantum Lorenz ordering is meant to rank a set of correlation matrices by the amount of dispersion reflected in their spectra: a true heterogeneity. We consider this dispersion from the standpoint of measurement error as has been in the application of random matrix theory (RMT) to correlation matrices in portfolio risk theory. We provide analytical relations between quantum majorization and random matrix cleaning for a few RMT filtering schemes posing quantum majorization as a desirable condition for RMT filtering. The RUP is tested using these RMT cleaned correlation matrices as well.Applied Mathematic
Respiratory Muscle Strength Training for Athletes: A Narrative Review
No full textRespiratory Muscle Training (RMT) has become an alternative approach to boost athletic performance by improving respiratory function and delaying inspiratory muscle fatigue. The objective of the present study is to synthesise recent works on the benefits of RMT regarding muscle strength, respiratory system function and exercise performance in athletes and healthy individuals. The reviewed studies suggest that RMT can significantly increase pulmonary function parameters; however, the impact of RMT on these parameters remains inconsistent across studies. Regarding exercise performance, RMT has been shown to improve endurance, as evidenced by increased time to exhaustion, VO2 max, Repeated Sprint Ability (RSA) and postural control in some studies. This author aimed to analyse the different studies on respiratory training with the aforementioned outcomes. A thorough search of studies were conducted using various databases. The review included studies published in English, which were peer-reviewed and focused on RMT interventions in sports players. The following keywords were used as search strategies: RMT, Inspiratory Muscle Training (IMT), pulmonary function, Maximum Inspiratory Pressure (MIP), Maximum Expiratory Pressure (MEP), exercise performance, VO2 max and endurance training. All 10 studies were extracted based on their research design, including randomised controlled trials, pre-post experimental studies, randomised sham-controlled trials and randomised group factorial designs and were synthesised and analysed qualitatively. The activation of the metaboreflex mechanism and improved blood flow distribution to working muscles during exercise are proposed as potential underlying mechanisms for these performance benefits. However, the additive effects of RMT when combined with regular strength and endurance training remain debatable. The present analysis identified a suitable metric that could substantiate the evidence supporting the enhancement of athletic performance through RMT
IN A PERSONAL INFORMATION RETRIEVAL SYSTEM
No full textThis paper is based on a doctoral disserfiation by the first author. Support from the iUationai Science Foundation under ~rmt 'No. DCR71-02038 is gratefully acknowle8ged. Those wishing more mmplete details about system c a d s and imp.tomentatioa should,write the s-d author for a User's Manual
Not Available
No full textNot AvailableA qualitative as well as quantitative categorization of seed storage proteins profiles of 23 genotypes of Trigonella foenum graecum L. were performed by using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) for exploring
the level of genetic discrepancy at seed storage protein level. Total soluble proteins were resolved on 10% resolving gel. A
dendrogram was constructed on the basis of weight of seed storage proteins, which divide total genotypes into two groups
further classified into different sub groups containing different genotypes in them. The bands obtained from gel electrophoresis
can serve as a potent tool in discrimination of different genotypes on the basis of their protein content. Proteins with
molecular weight 66, 43 and 35 kDa were found in all the genotypes except Fgk-76, PR, Rmt-303, PEB and Rmt-361, The
43 kDa protein band was found missing in Fgk-67, AFg-2, AM-2, AFg-4, Fgk-73, although the protein with 35 kDa weight
was present in all the genotypes but not in Rmt-303 same as 63 kDa which is not present in Fgk-70 and 55 kDa protein
band was found missing in Fgk-67, Afg-4 and Rmt-361.Not Availabl
Causality Analysis between Electricity Consumption, Real GDP, Foreign Direct Investment, Human Development and Remittances in Colombia, Ecuador and Mexico
No full textThis paper examines the relationship between electricity consumption (EC), gross domestic product (GDP), foreign direct investment (FDI), human development index (HDI) and remittances (RMT) for Colombia, Ecuador and Mexico using annual data from 1980 to 2012. Previous literature oversees the relevance of RMT in Latin America and the urgent need to improve HDI levels when analyzing EC and GDP linkages. Time series techniques test the causal relationships direction and its interaction sign. In Colombia there are two unidirectional causalities running from HDI to EC and GDP to FDI generating a positive effect, and bidirectional causality between HDI and RMT reflecting an enhancing feedback in the long-run. In Ecuador, a unidirectional direct causality from EC to GDP and a negative impact from RMT to GDP characterize for the long-run interaction. In Mexico, EC causes FDI in the short-run within a positive interaction, and FDI and HDI sustain short-run unidirectional causalities affecting RMT negatively exerted from FDI and positively from HDI. After reviewing the results, the author suggests policies to each country.
Keywords: electricity consumption; gross domestic product; foreign direct investment; human development index; remittances
JEL Classifications: C3; O4; Q4
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