1,354,349 research outputs found
Gene symbol: JAG1. Disease: Alagille syndrome
No full textA novel heterozygous mutation in exon 6 of Jag1 gene is describe
Enhancing Ethanol Removal from Wine: A Comparative Study of Reverse Osmosis, Nanofiltration and Osmotic Distillation
No full textEvaluation of physicochemical characteristics, color and volatile profile of low alcohol beverage based on concentrated white wine produced by NF and RO membranes
No full textMembrane-based technologies have emerged as vital methods for reducing or removing ethanol in winemaking. This study evaluates the efficacy of nanofiltration (NF-DK) and reverse osmosis (RO-SG) membranes in ethanol reduction for white wine, focusing on permeate flux behavior, fouling index, permeability, ethanol rejection rates, and retention of essential wine components. Experiments were conducted at 21 degrees C, achieving a weight reduction factor (WRF) of 4. The RO-SG membrane experienced a significant decline (78.2 %) in flux over 247 min to achieve WRF 4, whereas the NF-DK membrane exhibited a lesser flux decline of 49.2 %, reaching WRF 4 in just 40 min. Despite the higher ethanol rejection achieved by RO-SG (16.3 %) compared to NF-DK (1.8 %), ROSG demonstrated greater retention of critical compounds, including citric acid, tartaric acid, lactic acid, total acidity, glycerol, dry extract, and key volatile compounds. The produced low-alcohol wines, RO(B) (3.07 % v/v) and NF(B) (2.50 % v/v), showed significant physicochemical changes. Colorimetric analysis revealed deeper red hues and greater color intensity in RO(B) (0.28) compared to NF(B) (0.19) and the original wine (0.23), with a Delta E of 3.26 for RO(B), indicating pronounced visual deviations. Moreover, the retention of volatile compounds was substantially higher in RO(B) (55 %) compared to NF(B) (28 %), highlighting substantial differences in aroma and flavor. These findings highlight the potential of membrane-based approaches for ethanol reduction while emphasizing their impact on key quality parameters, providing valuable insights for the scalable production of low-alcohol wines with controlled compositional attributes
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Characterization of olive mill wastewater fractions treatment by integrated membrane process
No full textBACKGROUND: Up to now, the management of olive mill wastewaters, a three-phase mill by-product, remains an unsolved problem, in particular for those regions where huge quantities of vegetable water are produced. Olive mill wastewaters were therefore treated to evaluate the characteristics of permeate and retentate fractions produced by an integrated membrane systemworking at two different volume concentration factors.
RESULTS: The effect of two membrane-based filtration steps (microfiltration and nanofiltration) on the content of chemical oxygen demand, dry matter, sensory quality, phenolic compounds and antioxidant activity of permeate and retentate samples was evaluated. Furthermore, the effect of two different volume concentration factors (VCF), in the nanofiltration step, were investigated. At high VCF values, the total phenolic content in the retentate fraction was found to be 3.7-fold higher than the starting one, while the reduction of chemical oxygen demand in the permeate fraction was greater than 97%also at lower VCF values.
CONCLUSION: Each filtration step has provided useful information concerning the utility and appropriateness of the processes chosen, suggesting a sustainable hypothesis of ‘normal industrial practice’ that can be included in current processes of oil extraction, in order to purify water and recover phenolic compounds with high added value
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A new truncating MPZ mutation associated with a very mild CMT1 B phenotype
No full textWe have investigated a 34-year-old female who had mild clinical and electrophysiological features of demyelinating peripheral neuropathy. She presented a novel frameshift mutation (V160fsX3) in the exon 4 of the Myelin Protein Zero (MPZ) gene. Clinical and genetic studies performed on her family revealed the same mutation in her oligosymptomatic mother and sister. Our report expands the number of MPZ mutations and indicates that mutations in exon 4 may cause a mild Charcot-Marie-Tooth type 1B phenotype
Novel human pathological mutations. Gene symbol: SPG4. Disease: spastic paraplegia, autosomal dominant
No full textDispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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