187,044 research outputs found
POS0370. Type i interferon pathway assays in patients with rheumatic and musculoskeletal diseases - systematic literature review (slr) and development of consensus terminology from a eular taskforce
No full textPosterBurska, A., Rodríguez Carrio, J., Conaghan, P. G., Dik, W. A., Biesen, R., Elorana, M. L., Cavalli, G., Visser, M., Boumpas, D., Bertsias, G., Wahren-Herlenius, M., Rehwinkel, J., Frémond, M. L., Crow, M. K., Ronnblom, L., Vital, E., Versnel, M
Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
No full textEULAR [SCI019]; UK National Institute for Health and Care Research (NIHR) Leeds Biomedical Research CentreRodríguez-Carrio J, Burska A, Conaghan PG, Dik WA, Biesen R, Eloranta ML, Cavalli G, Visser M, Boumpas DT, Bertsias G, Wahren-Herlenius M, Rehwinkel J, Frémond ML, Crow MK, Ronnblom L, Vital E, Versnel
Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data from 3000 community referrals for shoulder pain
No full textBackground Ultrasound is increasingly used to evaluate shoulder pain but the benefits of this are unclear. This study examined whether ultrasound-defined pathologies have implications for clinical outcomes. Methods We extracted reported pathologies from 3000 ultrasound scans of people with shoulder pain referred from primary care. Latent class analysis (LCA) identified whether individual pathologies clustered in groups. Optimal group number was determined by the minimum Bayesian information criterion. A questionnaire was sent to all patients scanned over a 12-month period (n=2322). Data collected included demographics, treatments received, current pain and function. The relationship between pathology-defined groups and clinical outcomes was examined. Results LCA revealed four groups: 1. bursitis with limited inflammation elsewhere (n=1280); 2. bursitis with extensive inflammation (n=595); 3. rotator cuff tears (n=558); 4. limited pathology (n=567). 777 (33%) completed questionnaires; median (IQR) duration post-ultrasound scan was 25 (22, 29) months. Subsequent injections were most common in groups 1 & 2 (groups 1-4: 76%; 67%; 48%; 61%); surgery was most common in group 3 (23%; 21%; 28%; 16%). Shoulder Pain and Disability Index scores were highest in group 3 (median 48 and 30 respectively) and lowest in group 4 (32 and 9). Patients in group 4 who had surgery reported poor outcomes. Conclusion In a community-based population, ultrasound identified clusters of pathologies. Our retrospective data suggests these groups have different treatment pathways and outcomes. This requires replication in a prospective study to determine the value of a pathology-based classification in people with shoulder pain
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice
No full textThis work was funded by the European Alliance of Associations for Rheumatology (EULAR) (grant number SCI019). PGC and EMV are supported in part by the UK National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre.Rodríguez-Carrio, J., Burska, A., Conaghan, P.G., Dik, W.A., Biesen, R., Eloranta, M.-L., Cavalli, G., Visser, M., Boumpas, D.T., Bertsias, G., Wahren-Herlenius, M., Rehwinkel, J., Frémond, M.-L., Crow, M.K., Rönnblom, L., Versnel, M.A., Vital, E.M
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