322,991 research outputs found
Il compasso di S. Antonio in Polesine
No full textIndagine sulla presenza di un compasso, dalla fisionomia assai particolare, nel monastero medievale di Sant'Antonio in Polesine (Ferrara)
XXVI Compasso d'Oro Targa Giovani - Sil-O-Safe
No full textRespiratore di emergenza per chi lavora in spazi chiusi come cisterne, silos e serbato
Attività nel laboratorio di matematica: costruzioni con riga e compasso.
No full textIn questo lavoro si presentano gli elementi essenziali di una sperimentazione didattica sul compasso e sulle costruzioni geometriche in una classe prima di scuola secondaria di primo grado, condotta nel contesto del laboratorio di matematica
Cytokine production in scleroderma patients: effects of therapy with either iloprost or nifedipine
No full textObjective. To compare the long-term effects of intermittent infusion of iloprost with those of oral nifedipine on the in vitro production of cytokines in patients with systemic sclerosis (SSc), and to evaluate their relationship with the effects of the two treatments on clinical parameters. Methods. The production of cytokines by alloactivated circulating mononucleated cells was assessed before and after one year of treatment in a subset of 31 patients enrolled in a 12-month randomized clinical trial. Nineteen patients were treated with a 5-day (8 hr per day), 20 ng/kg per minute infusion followed by a 1-day infusion every 6 weeks: 12 patients were treated with an oral slow-release formulation of nifedipine, 20 mg twice daily. Quantitative determinations of interleukin-1 β(IL1-β) and interleukin-6 (IL6) in the culture supernatants were performed with a commercial ELISA: the levels of tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured by specific radioimmunometric assays. Results. The production of IL1-β was significantly lower in the iloprost group than in the nifedipine group. Both the cutaneous fibrosis and the capillaroscopic patterns were better in patients treated with iloprost than in patients treated with nifedipine. There was a significant positive covariance between IL-1β changes and the changes in both the skin score and the capillaroscopic score. Conclusion. There are several mechanisms by which iloprost could exert its clinical efficacy. Vasodilatation and inhibition of platelet aggregation are certainly important, but they are transient. We, suggest that the long-lasting modulation of the cytokine network observed in the present study could be another potential mechanism responsible for the persistent efficacy of iloprost despite its intermittent administration
Modulazione della sintesi in vitro di citochine da parte dei metaboliti della via cicloossigenasica
No full textDifferential effects of cyclo-oxygenase pathway metabolites on cytokine production by T lymphocytes
No full textCyclo-oxygenase pathway metabolites released in the microenvironment by activated platelets and endothelial cells are potential local modulators of the immune response. In the present study, we have investigated the modulatory role of PGE2, Iloprost (prostacyclin analogue) U-46619 (thromboxane analogue) on the release of IL-2, IFN-gamma, TNF-alpha and IL-6 by T lymphocytes. Our results show that PGE2, and prostacyclin differ in the regulation of cytokine production. PGE2, inhibited the release of IL-2 and IFN-gamma, while Iloprost did not affect their production. The addition of PGE2, or Iloprost greatly decreased the amount of TNF-alpha measured in the supernatants, although the rates of inhibition differed according-to the kind of stimulation. Unlike that of PGE2, inhibition by Iloprost was stronger in alloactivated cultures than in PHA-stimulated ones. In vitro IL-6 production was stimulated by PGE2, in alloactivated cultures and by Iloprost, whatever the stimulus. These results are probably due to other cellular subsets contaminating the T-lymphocyte preparations. After complete removal of monocytes from cell cultures, there were inhibitory effects of Iloprost and PGE2, on IL-6 released in the supernatants. We did not observe any significant effect of thromboxane analogue on the production of either cytokine
Construções com régua e compasso
No full textDesde os primórdios, os povos se interessavam por construções com régua e compasso.
As inquietações sobre quais construções eram ou não possíveis com o uso destes instrumentos
contribuíram, e contribuem até os dias atuais, para a evolução de diversas áreas
de conhecimento dentro e fora da Matemática. Explanamos, aqui, resultados da Teoria de Grupos, do estudo de Polinômios e de
Extensões de Corpos, da Teoria de Galois e da forma como esta última relaciona conceitos
envolvendo grupos e corpos. Resultados esses, que nos darão respaldo para tratarmos das questões de construtibilidade, em especial, da problemática sobre quais polígonos regulares são construtíveis com régua e compasso e, de forma mais breve, dos três problemas gregos clássicos.São Cristóvão, S
Palermo University and Compasso Volante
No full textThe University of Palermo joins since few years the Compasso Volante Competition, that is still keeping, in different ways, its original spirit.
The city of Palermo has represented in two different Editions the project site and, last year, Palermo hosted for the second time the Award Ceremony. Palermo has been made available to the awarding of the XV Edition, thanks to the enthusiasm and pleasure that students and professors have shown in the past. The paper present the result of the Edition that has take place in Macau, Hong Kong, Milano and Palermo
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