179,889 research outputs found
Nomos e Rappresentazione. Ripensare metodi e funzioni del diritto comparato
No full textL’itinerario intellettuale racchiuso nelle pagine del volume intende interrogare criticamente i paradigmi metodologici e le funzioni proprie del diritto comparato, proponendo una visione sinottica in grado di privilegiare le sollecitazioni e gli apporti che possano provenire da altre forme di sapere. La riflessione si snoda intorno a tre nuclei tematici che considerano i modi in cui la comparazione ha letto il Giuridico rispettivamente nelle sue apparizioni fenomeniche, nel suo dimensionamento spaziale, nelle sue plurali rappresentazioni discorsive e testuali. Per attribuire rilevanza estetica a questa partizione nell’economia compositiva del libro, si è scelto di nominare ogni sezione con una parola chiave che ne sia al contempo traduzione sintetica ed evocativa: Presenze; Dislocazioni; Visioni. L’intento conclusivo è quello di avanzare una prospettiva originale che riguardi non solo il fare del diritto comparato, ma anche il suo dire
Brugada phenocopy in diabetic ketoacidosis, the importance of the diagnostic approach
No full textBrugada phenocopies (BrP) are clinical entities that present with identical ECG patterns to those of true Brugada Syndrome (BrS) but are elicited by various other clinical circumstances. Our manuscript shows an interesting case of a type-1 Class A BrP in a young patient with diabetic ketoacidosis and hyperkalemia
Nota a sentenza della Corte di Giustizia dell???Unione Europea (quinta sezione), 8 maggio 2014, causa C-15/13, Technische Universität Hamburg-Harburg e Hochschul-Informations-System GmbH c. Datenlotsen Informationssysteme GmbH, in Diritto Pubblico Comparato ed Europeo, n. 3/2014, pp. 1370-1372.
No full textNota a sentenza della Corte di Giustizia dell’Unione Europea (quinta sezione), 8 maggio 2014, causa C-15/13, Technische Universität Hamburg-Harburg e Hochschul-Informations-System GmbH c. Datenlotsen Informationssysteme GmbH, in Diritto Pubblico Comparato ed Europeo, n. 3/2014, pp. 1370-1372
Nota a sentenza della Corte di Giustizia dell???Unione Europea (quinta sezione), 19 giugno 2014, causa C-574/14, Centro Hospitalar de Setúbal EPE, Serviço de Utilização Comum de Hospitais (SUCH) c. Eurest (Portugal) - Sociedade Europeia de Restaurantes Lda, in Diritto Pubblico Comparato ed Europeo, n. 3/2014, pp. 1373-1374.
No full textNota a sentenza della Corte di Giustizia dell’Unione Europea (quinta sezione), 19 giugno 2014, causa C-574/14, Centro Hospitalar de Setúbal EPE, Serviço de Utilização Comum de Hospitais (SUCH) c. Eurest (Portugal) - Sociedade Europeia de Restaurantes Lda, in Diritto Pubblico Comparato ed Europeo, n. 3/2014, pp. 1373-1374
La tutela urgente nei confronti dell'attività amministrativa illegittima. Uno sguardo comparato
No full textSi tratta di un libro di diritto comparato ed è il primo in materia di tutela cautelare. L'analisi è articolata individuando alcuni punti essenziali e ricercando la "risposta" fornita dai vari ordinamenti (italia, spagna, argentina, uruguay, messico, brasile) alla domanda di tutela.
A differenza di molti lavori di diritto comparato, ha ad oggetto il diritto dei paesi di lingua spagnola, che costituise un campo di analisi essenziale, soprattutto in prospettiva, per il giurista contemporane
Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in the absence of lipid lowering
No full textThe expression of tissue factor (TF), mainly by infiltrated inflammatory cells, has been shown to be responsible for the thrombogenicity associated with atheroma. The contribution of the nonlipid-related effects of statins to the clinical benefits of statin therapy is currently under intense investigation. In this study, we evaluated the ability of fluvastatin to modulate TF expression and macrophage accumulation in rabbit carotid intimal lesions independently of cholesterol lowering. Male rabbits were fed for 30 days a 1% cholesterol-rich diet with or without fluvastatin at 5 mg/kg per day. Two weeks from the start of treatment, a silastic collar was placed around the carotid artery. Fifteen days later, the animals were killed, and carotid segments were excised and processed. The atherogenic diet caused a consistent increase in plasma cholesterol levels (610+/-231 mg/dL versus 50+/-9 mg/dL at baseline), which were not affected by fluvastatin (603+/-248 mg/dL). In the rabbits fed a high cholesterol diet without fluvastatin, an intimal lesion with macrophage accumulation and TF expression was detected. Fluvastatin significantly reduced TF and macrophage content of the lesion (-50% for both). Results indicate that fluvastatin may attenuate the inflammatory and thrombogenic potential of atherosclerotic lesions through a mechanism(s) other than cholesterol reduction, providing new insight regarding the complex mode of action of statins
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinically relevant pleiotropic effects of statins: drug properties or effects of profound cholesterol reduction?
No full textClinical trials have firmly established that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) can induce the regression of vascular atherosclerosis and reduce cardiovascular-related morbidity and death in patients with and without coronary artery disease. It is usually assumed that these beneficial effects are due to the ability of statins to reduce cholesterol synthesis. However, because mevalonic acid is not only the precursor of cholesterol but also of many non-steroidal isoprenoid compounds, the inhibition of HMG-CoA reductase may lead to pleiotropic effects. As shown by the data reported in this review, some statins can interfere with major events involved in the formation of atherosclerotic lesions, regardless of their hypolipidemic properties. The relevance of these effects in humans remains to be established (particularly in view of the high statin doses required to produce a direct vascular action), thus their contribution to the reduction in cardiovascular events observed in clinical trials has become one of the major challenges for future studies aimed at clarifying the anti-atherosclerotic benefits of statins
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