1,721,033 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Material and cell biological characterization of cell-laden hydrogels functionalized by plant virus nanoparticles to enhance osteogenic differentiation
No full textPflanzenvirus-Nanopartikel (VNP) sind eine nützliche biokompatible Plattform mit vielseitigen monodispersen Proteinstrukturen, die mit bioaktiven Signalen versehen werden können und Möglichkeiten zur Funktionalisierung von bioinerten Hydrogelen für das Tissue Engineering bieten. Die Hypothese in dieser Studie war, dass die Osteogenese humaner mesenchymaler Stammzellen (hMSCs) und die Biomineralisation durch die Einarbeitung von VNPs, die mit Osteogenese-assoziierten oder zelladhäsiven Peptiden versehen waren, in zellbeladenen Hydrogelen verstärkt werden können. Die zellulären Reaktionen auf VNPs wurden sowohl in 2D- als auch in 3D-Kulturen untersucht, einschließlich VNP-Zellverteilung, Zellanhaftung, Morphologie und Osteogenese. VNP-beladene Agarose- oder Agarose-Kollagen-Hydrogele wurden hinsichtlich der Freisetzungsrate, des Mineralisierungseffekts, der mechanischen Eigenschaften und der Verwendungsmöglichkeit in der Biotinte charakterisiert. Die Ergebnisse offenbarten eine verstärkte osteogene Differenzierung, wenn Zellen auf VNP-beschichteten Oberflächen kultiviert wurden. Die Anhaftung von VNPs an Zellen sowie eine VNP-Retention von mindestens 84 % wurden in Hydrogelen beobachtet. Der Mineralisierungseffekt war in VNP-beladenen Hydrogelen ausgeprägt, was auch die Überlegenheit der angereicherten Peptide auf VNPs gegenüber freien Peptiden und VNPs mit weniger Peptiden zeigte. Schließlich konnte eine gute Reproduzierbarkeit beim Bioprinting mit VNP-beladenen Hydrogelen nachgewiesen werden. Perspektivisch könnten VNPs mit Vaskulogenese-induzierenden Faktoren konjugiert werden, um dadurch möglicherweise effektiver 3D-gedruckte In-vitro-Prävaskularisation zu induzieren
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Displaying functional molecules on plant virus-based nanoparticles
No full textPlant virus nanoparticles (VNPs) have many unique advantages, including their ability to self-assemble with precise symmetry and polyvalency, their monodispersity and stability under a range of conditions, their inherent safety (biocompatibility and non-infectivity in mammals), and the rapid, simple and scalable production that can be achieved by molecular farming in plants. The structures of many plant viruses have been solved at atomic or near-atomic resolution and the genome sequences are well characterized, so plant VNPs can easily be modified to introduce new functions. However, selection for smaller genomes often causes the loss of transgenes during infection. This can be addressed by using the ribosomal skip (overcoat) strategy or chemical conjugation, although this reduces the density of peptides on the particle surface. This thesis describes new plant virus display systems for applications such as bone tissue engineering, bioimaging and plant biomass degradation. The first chapter describes Potato virus X (PVX) engineered to present mineralization-inducing peptides (MIPs) equivalent to non-collagenous proteins of the extracellular matrix. The mineralization of recombinant PVX particles was achieved using saturated hydroxyapatite solution and simulated body fluid, which closely mimic the mineral phase of human bone. These studies lay the foundations for the further exploitation of biomimetic VNPs in bone regeneration. The second chapter describes iLOV-displaying PVX and Tobacco mosaic virus (TMV) nanoparticles for bioimaging, which currently requires overcoating or chemical conjugation. Surprisingly, PVX particles with direct iLOV-coat protein (CP) fusions were infectious but this was not the case for TMV. The PVX particles may be useful for molecular imaging under low oxygen conditions, such as tumor metastasis, or for the analysis of particle behavior in hydrogels when combined with MIPs. A new strategy for protein display on TMV is also described, using a ribosomal skip sequence. Although not directly comparable, an eight-fold increase in the abundance of the displayed iLOV target protein was achieved compared to a malaria epitope fusion proteins created by using a read-through motif (Turpen et al., 1995), which may be advantageous in particular for vaccine production. The third chapter explores PVX and TMV as biocatalysts, using the protein-based attachment of endoglucanases as a case study. SpyTag/SpyCatcher technology allowed the rapid formation of a stable isopeptide bond between the enzyme and scaffold. The catalytic efficiency of flexible recombinant PVX particles was higher than that of rigid TMV particles, indicating that the morphology of the template influences catalytic activity. The results presented in this thesis provide new insights into PVX and TMV display systems and will be beneficial for many application areas by overcoming the limitations of genetic fusions, such as size constraints and the need for post-translational modifications
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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