170,053 research outputs found
C. N. Colyer et C. O. Hammond. — Les mouches des Iles britanniques (Flies of the British Isles) , 1951
No full textd'Aguilar Jacques. C. N. Colyer et C. O. Hammond. — Les mouches des Iles britanniques (Flies of the British Isles) , 1951. In: Bulletin de la Société entomologique de France, volume 56 (10), décembre 1951. p. 155
An investigation of structure-function relationships of (Ca2-Mg2+)- ATPase with monoclonal antibodies
No full textThirty seven monoclonal antibodies (mAbs) were generated against (Ca2+-Mg2+)-ATPase from rabbit skeletal muscle sarcoplasmic reticulum for the purpose of studying structure-function relationships. No conformation specific (E1, E2) antibodies were found, indicating the limited extent of structural alteration of the antibody binding sites (epitopes) during calcium transport, which may reflect the magnitude of change accompanying E1-E2 transitions. Five distinct binding regions were identified on the ATPase by competitive binding of labelled and unlabelled mAbs. Limited proteolysis of the ATPase enabled description of the epitope location of 14 mAbs in the primary sequence. Following digestion of ATPase, anti-peptide antibodies specific for the N- and C-termini of the ATPase were used to identify the origin of fragments recognised by individual mABs. Antibody epitopes were defined to an apparent resolution of 11-16 residues, although these limits were extended to 75-94 residues in the absence of the precise molecular weight of proteolytic fragments. Ten mAbs (6 of which bind in the same spatial region, as defined in competitive displacement assays) produce inhibition of ATPase activity (30-70% inhibition). Inhibition was generally more marked at low ATPase concentrations (1-10μM) but a return to control levels of activity was not exhibited at high ATP (1-10mM). Release of enzyme-bound calcium at steady state was used as a measure of the ratio of E1_total/E2_total. This ratio was reduced by one inhibitory mAb, consistent with a reduction in the rate of dephosphorylation. Three other inhibitory mAbs increased this ratio, without stabilising E1. One of these (the only one tested) also decreased the rate of phosphoenzyme formation by ATP, and the concentration of phosphoenzyme at steady state. Potential mechanisms of inhibition of ATPase activity compatible with the data in the presence of mAb are discussed.</p
The registers of the French Church, Threadneedle Street, London.
No full textVol. 3 printed at Aberdeen by the Aberdeen University Press ltd.; v. 4, at London by Spottiswoode, Ballantyne & Co. ltd.Vols. 3-4 edited by T. C. Colyer-Fergusson.Nos. 153, 246, 292 and 389 of an edition of 450 copies."The register commences in 1599-1600 and ends in 1840."--Foreword.Mode of access: Internet
Experimental and theoretical study of the triple-differential cross section for electron-impact ionization of thymine molecules
No full textTriply differential cross sections for the electron-impact ionization of inner valence orbitals of thymine have been measured using the (e,2e) technique at an incident electron energy of 250 eV. The measurements have been performed with coplanar asymmetric kinematics for scattered electron angles of –10° and –15° and with an ejected-electron energy of 20 eV. Theoretical calculations have been performed within the first-order Born approximation and are in very good agreement with the experimental data.S. M. Bellm, C. J. Colyer, B. Lohmann, and C. Champio
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Elastic electron scattering from the DNA bases: cytosine and thymine
No full textRelative elastic differential cross sections for elastic scattering from cytosine and thymine have been measured using the crossed-beam method. The measurements have been performed at two electron energies of 500 and 100 eV, and cover the angular range of 10°-130°. Calculations of elastic differential cross sections have been performed via the screen corrected additivity rule method, and agreement is quite good with the present experimental results. The results obtained are important for the modelling of energy deposition in living tissue.C.J. Colyer, S.M. Bellm, F. Blanco, G. Garcia and B. Lohman
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
ENVIRONMENTAL IMPACTS OF AGRICULTURAL TRADE UNDER NAFTA
No full textNAFTA was the first trade liberalization agreement to explicitly include environmental provisions. Both agricultural trade and U.S. FDI in the Mexican food processing and agricultural sectors have increased since NAFTA's implementation. Environmental implications include a greater emphasis on the environment in Mexico as well as positive and negative impacts due to changes in scale, structure and technology in those sectors. Increased use of chemicals due to both increased outputs and a shift to greater horticultural crop production have negative impacts on the Mexican environment but improved technologies in processing produce favorable effects.Environmental Economics and Policy, International Relations/Trade,
ENVIRONMENTAL REGULATIONS AND COMPETITIVENESS
No full textCosts of environmental regulations, although relatively small, can be critical in the competitiveness of a product since the cost advantages of producers in one country are often very slim. Additional costs derived from new regulations are a factor in the continued importance of exports and of the maintaining or increasing a nations share of the international market. Governments try to assist their industries in overcoming the disadvantages caused by such added cost through subsidies, tax breaks, technical assistance or in other ways. In agriculture these are increasingly taking the form of green payments, which are currently exempt from the limits imposed on domestic subsidies. In addition to these mechanisms for addressing the environment, there also has been a selective but subversive process of erecting non-tariff barriers based on environmental protection issues. It is often difficult to determine if such measures are really for protecting the environment or for protecting domestic producers. They are, none-the-less, generally effective approaches for achieving environmental objectives and can also be effective measures to alter competitiveness. Competitiveness can be either enhanced or diminished by the environmental regimes of competing nations. The existence of negative externalities means that prices are lower than would prevail if all costs where included in the prices of the products.Environmental Economics and Policy, International Relations/Trade,
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