1,302 research outputs found
Characterization of cell wall degrading enzymes from Chrysosporium lucknowense C1 and their use to degrade sugar beet pulp
No full text Key words: Pectin, arabinan, biorefinery, mode of action, branched arabinose oligomers, ferulic acid esterase, arabinohydrolase, pretreatment Sugar beet pulp is the cellulose and pectin-rich debris remaining after sugar extraction from sugar beets. In order to use sugar beet pulp for biorefinery purposes, these carbohydrates need to be degraded to fermentable monosaccharides.The influence of six mild sulfuric acid or water pretreatments at different temperatures on the enzymatic degradability of sugar beet pulp was examined. An optimal pretreatment of 15 min at 140 °C in water greatly facilitates the subsequent enzymatic cellulose degradation. Enzymatic degradation of pectin requires an array of different enzyme activities. To this end, cell wall degrading enzymes of the filamentous fungus Chrysosporium lucknowense C1 (C1) were purified and characterized. Four arabinohydrolases from C1 were characterized that released up to 80% of the arabinose present in sugar beet arabinan as monomers. A combination of three arabinohydrolases also released unknown branched arabinose oligomers, which were purified and identified using NMR analysis. With the help of these complex arabinose oligomers the mode of action of four C1 α-L-arabinohydrolases was determined to enable controlled and tailored degradation of arabinan. Complete degradation of sugar beet pulp also requires ferulic acid esterase activity. Three C1 ferulic acid esterases were purified and characterized, of which one could release up to 60% of ferulic acid from feruloylated sugar beet pectin oligomers, whereas the other two were more active toward feruloylated arabinoxylan. </p
Introducing the C1 Wedge Connection
No full textIncreasing loads on the connections of tubular towers that support wind turbines are making the traditional bolted L-flange more challenging to design, while the large mass of components and tools make installation challenging from a safety perspective. The C1 Wedge Connection is a symmetrical connection between tubular sections. The connection consists of a cylindrical lower flange and a fork-shaped upper flange that slides over the lower flange. Both flanges have radial elongated holes distributed along the perimeter allowing the C1 fasteners to pull the two flanges together. The fastener assembly of the C1 Wedge Connection uses a small, horizontally placed bolt to pull two wedges together. The wedges transform and magnify the horizontal bolt force into a larger preload between the flanges by pulling them together. The orientation of the bolt in the fastener prevents significant load fluctuations under external loading. As a result, unlike a bolted L-flange, the C1 Wedge Connection is less susceptible to preload loss, thereby eliminating the need for regular maintenance and inspection. The scalability of the C1 Wedge Connection makes it suitable for larger loads. These larger loads are expected with increasing size of wind turbines and when connections are used in more demanding locations such as hurricane and seismic conditions or where connections are subjected to high dynamic loads caused by extreme wave conditions or on floating foundations.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Steel & Composite Structure
Differential melting curves for the complexes PL1 + C1 (or C2) (), PL2 + C2 (C1) (); EC1 + C1 (or C2) (), EC2 + C2 (C1) (); MB1 + C1 (or C2) (), MB2 + C2 (C1) ()
No full text<p><b>Copyright information:</b></p><p>Taken from "Novel DNA probes with low background and high hybridization-triggered fluorescence"</p><p></p><p>Nucleic Acids Research 2007;35(5):e30-e30.</p><p>Published online 26 Jan 2007</p><p>PMCID:PMC1865069.</p><p>© 2007 The Author(s).</p
Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression
No full textCoronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is associated with a clinical spectrum ranging from asymptomatic carriers to critically ill patients with complications including thromboembolic events, myocardial injury, multisystemic inflammatory syndromes and death. Since the beginning of the pandemic several therapeutic options emerged, with a multitude of randomized trials, changing the medical landscape of COVID-19. The effect of various monoclonal antibodies, antiviral, anti-inflammatory and anticoagulation drugs have been studied, and to some extent, implemented into clinical practice. In addition, a multitude of trials improved the understanding of the disease and emerging evidence points towards a significant role of the complement system, kallikrein-kinin, and contact activation system as drivers of disease in severe COVID-19. Despite their involvement in COVID-19, treatments targeting these plasmatic cascades have neither been systematically studied nor introduced into clinical practice, and randomized studies with regards to these treatments are scarce. Given the multiple-action, multiple-target nature of C1 inhibitor (C1-INH), the natural inhibitor of these cascades, this drug may be an interesting candidate to prevent disease progression and combat thromboinflammation in COVID-19. This narrative review will discuss the current evidence with regards to the involvement of these plasmatic cascades as well as endothelial cells in COVID-19. Furthermore, we summarize the evidence of C1-INH in COVID-19 and potential benefits and pitfalls of C1-INH treatment in COVID-19
C1-stably shadowable chain components are hyperbolic
No full textAbstractLet f be a diffeomorphism on a closed manifold, and p be a hyperbolic periodic point of f. Denote Cf(p) the chain component of f that contains p. We say Cf(p) is C1-stably shadowable if there is a C1-neighborhood U of f such that for every g∈U, Cg(pg) has the shadowing property, where pg is the continuation of p. We prove in this paper that if Cf(p) is C1-stably shadowable, then Cf(p) is hyperbolic
Cervical Myelopathy by C1 Posterior Tubercle Impingement in a Patient With DISH
No full textStudy Design. A unique case of a patient with diffuse idiopathic skeletal hyperostosis (DISH) associated with C1 posterior tubercle impingement resulting in spinal canal stenosis and cervical myelopathy. Objective. To describe an uncommon mechanism of spinal cord compression in patient with DISH. Summary of Background Data. The neurological deficits due to cervical DISH are relatively rare and a few cases of cervical spinal cord compression due to atlantoaxial subluxation, odontoid fracture, pseudotumor, ligamentous hypertrophy and basilar impression have been reported. To the best of our knowledge, there has been no other report of a patient with DISH causing C1 posterior tubercle impingement and cervical myelopathy. Methods. 75-year-old Japanese man, first diagnosed as hyperostosis of anterior and posterior longitudinal ligament 25 years ago, presented with gradual progression of numbness in both lower extremities, disturbed precise hand motion and urinary function. DISH, OPLL, and C1 posterior tubercle impingement was diagnosed by radiograph, CT, and MRI. Hyperintense signal in the C1 spinal cord on T2 weighted sequence was observed. Result. Laminectomy from C1 to C3 was performed. Myelocompression and myelopathy improved after the surgical intervention. Multilevel fusion of the subaxial cervical spine and increase of the mechanical stress on the craniocervical segment may leads to partial damage of the ligaments and resulted in C1 posterior arch impingement. Conclusion. This is the first report of unique C1 posterior tubercle impingement and myelopathy caused by DISH. We should keep it in mind that DISH can cause serious problems in the upper cervical spine even after 25 years of interval
Amplitude analysis of the chi(c1) -> eta pi(+)pi(-) decays
No full textKolcu, Onur Buğra (Arel Author)Using 448.0 x 10(6) psi(3686) events collected with the BESIII detector, an amplitude analysis is performed for psi(3686) -> gamma chi(c1), chi(c1) ->eta pi(+)pi(-) decays. The most dominant two- body structure observed is a(0)(980)(+/-) pi(-/+); a(0)(980)(+/-) -> eta pi(+/-.) line shape is modeled using a dispersion relation, and a significant nonzero a(0) (980) coupling to the eta'pi channel is measured. We observe chi(c1) -> a(2)(1700)pi production for the first time, with a significance larger than 17 sigma. The production of mesons with exotic quantum numbers, J(PC) = 1(-+), is investigated, and upper limits for the branching fractions chi(c1) -> pi(1)(1400)(+/-)pi(-/+) , chi(c1) -> pi(1)(1600)(+/-)pi(-/+) and chi(c1) -> pi 1(2015)(+/-)pi(-/+) with subsequent pi(1)(X)(+/-) -> eta pi(+/-) decay, are determined
Glove for input device of virtual reality simulation system
No full textAbstract of NL 1000617 (C1) The user wears a flexible glove (6) which is retained on the wearer's wrist by an adhesive band (7). The graphite filled tubes (1) run along two or more fingers and the thumb. The wires from the tubes are run around the wrist belt (7) to cables connected to the computer
On C1 classifications of hyperbolic vector fields
No full textAbstractIn this paper we study smooth classification of hyperbolic vector fields based on their linear approximations only and obtain the following. On Rn, n⩽5, with only two kinds of exceptions, any two hyperbolic vector fields with generic nonlinear parts ẋ=A1x+⋯ and ẏ=A1y+⋯, where Ai are n×n matrices, are C1 conjugate to each other if and only if A1 and A2 are strictly similar, and they are C1 orbitally equivalent if and only if A1 and A2 are similar
Global minimum and orthogonality in C1-classes
No full textCollege of Science, Department of Mathematics, PO Box 2455, Riyadh 11451, Saudi ArabiaIn this paper we characterize the global minimum of an arbitrary function defined on a Banach space, in terms of a new concept of derivatives adapted for our case from a recent work due to D.J. Keckic (J. Operator Theory, submitted for publication). Using these results we establish several new characterizations of the global minimum of the map defined by Fψ(X)=ψ(X)1, where ψ :U→C1 is a map defined by ψ(X)=S+φ(X) and φ :B(H)→B(H) is a linear map, SC1, and U={XB(H): φ(X)C1}. Further, we apply these results to characterize the operators which are orthogonal to the range of elementary operators.This work is supported, for the first author, by the Research Center Project Math/1422/10 and for the second
author by the Research Center Project Math/1422/22
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