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Tech Stories
No full textMostra TECH STORIES
La mostra racconta attraverso due percorsi espositivi complementari storie di ingegneria, di architettura, di design, di scoperte tecniche e innovazione scientifica che costellano i 150 anni del Politecnico di Milano. Storie che hanno lasciato un segno non solo a Milano, ma in tutto il Paese e, in alcuni casi, nel mondo intero.
A cura di Federico Bucci, Luisa Collina, Alessandro Colombo, Beppe Finessi, Sara Protasoni e Edoardo Rovida, e in collaborazione con il Museo Nazionale della Scienza e della Tecnologia,
Nuevos contextos, ¿nuevos desafíos? Estrategias virtuales para aprendizajes reales
No full textFil: Ayciriet, Federico. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Ayciriet, Federico. Universidad Nacional de Mar del Plata; Argentina.Fil: Bressan, David. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Bressan, David. Universidad FASTA, Mar del Plata; Argentina.Fil: Colombo, María Laura. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Colombo, María Laura. Universidad Tecnológica Nacional, Mar del Plata; Argentina.Este artículo presenta tres desafíos con los que nos hemos encontrado en nuestras prácticas como equipo
de trabajo y, a partir de los cuales, reflexionamos en conjunto. El objetivo es presentar estos tres desafíos
de modo problemático intentando esbozar las ideas que sostenemos en torno a cada uno de ellos. Estos
núcleos problemáticos son: ¿de qué hablamos cuando decimos «comunicarnos» con nuestrxs estudiantes?
¿Qué nos acompaña hoy en estas «aulas» sin espacio ni tiempo compartido? ¿Cómo hacer de la virtualidad
una oportunidad y no un obstáculo?Fil: Ayciriet, Federico. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Ayciriet, Federico. Universidad Nacional de Mar del Plata; Argentina.Fil: Bressan, David. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Bressan, David. Universidad FASTA, Mar del Plata; Argentina.Fil: Colombo, María Laura. Instituto Superior de Formación Docente Almafuerte; Mar del Plata; Argentina.Fil: Colombo, María Laura. Universidad Tecnológica Nacional, Mar del Plata; Argentina
Gallarate e Alto Milanese. A proposito di un recente libro di Federico Del Tredici
No full textThis article reviews a very influential book on early modern history of Lombardy written by Federico Del Tredici
Innovative approach for the treatment and the diagnosis of rheumatoid arthritis exploiting polymeric biodegradable nanoparticles targeting synovial endothelium
No full textRheumatoid arthritis (RA) is an autoimmune disease affecting joints due to the persistent inflammation of the synovial tissue. It affects 1% of the worldwide population with high socioeconomic costs. Patients usually require lifetime treatments in order to prevent late stage of the disease, which leads to a condition of disability and pain. Despite the introduction of biological drugs, Methotrexate (MTX) is still the gold standard. However, it shows some weakness such as inefficacy or adverse events after long term usage. For this reason, there is the need to develop drugs with an improved safety profile and higher therapeutic efficacy. Moreover, it is of primary importance to develop diagnostics with enhanced sensitivity and tissue specificity.
In order to meet these needs, the purpose of this work is to develop a nanotechnological agent capable to delivery its content, such as drugs or diagnostic tracers, specifically into pathological joints, avoiding healthy tissues.
These aims have been achieved exploiting peculiar features of biodegradable nanoparticles (BNPs), such as improved pharmacokinetic and bioavailability, associated to a peptide specific for the inflamed synovia. Recently, the heterogeneity of the molecules present in the endothelium has allowed to develop peptides capable to target vessels of specific tissues. In this project, a cyclic peptide able to target the microvasculature of the inflamed synovia has been exploited to drive BNPs only into inflamed joints.
BNPs have been characterized for their physicochemical features, polymers’ toxicity and drug release. Targeted polymeric nanoparticles (tBNPs) demonstrated, both in vitro and in vivo, to preferentially bind inflamed synovial tissue, and their accumulation depends from the degree of inflammation.
Targeted BNPs loaded with MTX showed higher efficacy compared to free MTX in two different animal models of RA. In addition, reduced dose of tBNPs-MTX demonstrated to maintain its efficacy, showing fewer side effects compared with systemic administration of free MTX. This new therapeutic approach provided a new mechanism of action from approved therapy and suggest potential application in non-responding patients.
All these evidences highlight the potential use of tBNPs as biocompatible and adaptable tool for the diagnosis and the treatment of RA showing important efficacy, reduced side effects and with the potential to enhance the sensitivity of several imaging technologies
Milano consolato nell' elettione a questo arciuescouado, e promotione alla sagra porpora dell' eminentissimo Federico Visconti : colla sua solennissima entrata seguita a' 11. genaro 1682 e fontioni antecedenti /
No full textFrontispiece coat of arms of Milan, engraved by Federico Agnelli.Signatures: pi⁴ A-G⁴ H⁴(-H4).Mode of access: Internet.Binding: limp vellum. Author & title written on spine
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