9,488 research outputs found
The Effects Induced by Spinal Manipulative Therapy on the Immune and Endocrine Systems
No full textBackground and Objectives: Spinal manipulations are interventions widely used by different healthcare professionals for the management of musculoskeletal (MSK) disorders. While previous theoretical principles focused predominantly on biomechanical accounts, recent models propose that the observed pain modulatory effects of this form of manual therapy may be the result of more complex mechanisms. It has been suggested that other phenomena like neurophysiological responses and the activation of the immune-endocrine system may explain variability in pain inhibition after the administration of spinal manipulative therapy (SMT). The aim of this paper is to provide an overview of the available evidence supporting the biological plausibility of high-velocity, low-amplitude thrust (HVLAT) on the immune-endocrine system. Materials and Methods: Narrative critical review. An electronic search on MEDLINE, ProQUEST, and Google Scholar followed by a hand and “snowballing” search were conducted to find relevant articles. Studies were included if they evaluated the effects of HVLAT on participants’ biomarkers. Results: The electronic search retrieved 13 relevant articles and two themes of discussion were developed. Nine studies investigated the effects of SMT on cortisol levels and five of them were conducted on symptomatic populations. Four studies examined the effects of SMT on the immune system and all of them were conducted on healthy individuals. Conclusions: Although spinal manipulations seem to trigger the activation of the neuroimmunoendocrine system, the evidence supporting a biological account for the application of HVLAT in clinical practice is mixed and conflicting. Further research on subjects with spinal MSK conditions with larger sample sizes are needed to obtain more insights about the biological effects of spinal manipulative therapy
La respuesta y sus vestidos : tipos discursivos y redes de poder en La respuesta a Sor Filotea
Full text linkFil: Colombi, Beatriz. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Departamento de Letras; Argentina
Moving in a crowd: Human perception as a multiscale process
Full text linkThe strategic behaviour of pedestrians is largely determined by how they perceive and react to neighbouring people. This issue is addressed in this paper by a model which combines, in a time and space-dependent way, discrete and continuous effects of pedestrian interactions. Numerical simulations and qualitative analysis suggest that human perception, and its impact on crowd dynamics, can be effectively modelled as a multiscale process based on a dual microscopic/macroscopic representation of groups of agents
Andrea Bacová
No full textAndrea Bacová focuses on research and teaching in the field of residential architecture. Her work includes systematic research on residential buildings and their urban context. She actively participates in promoting Slovak architecture and is the author of several publications and exhibitions
A Mathematical Model for Neuron Reorientation and Axonal Growth on a Cyclically Stretched Substrate
Full text linkExperiments have shown that mechanical cues play a central role in determining the direction and rate of axonal growth. In particular, neurons seeded on planar substrates undergoing periodic stretching have been shown to reorient and reach a stable equilibrium orientation corresponding to angles within the interval [60°, 90°] with respect to the main stretching direction. In this work, we present a new model that considers both the reorientation and growth of neurons in response to cyclic stretching. Specifically, a linear viscoelastic model for the growth cone reorientation with the addition of a stochastic term is merged with a moving-boundary model for tubulin-driven neurite growth to simulate the axonal pathfinding process. Various combinations of stretching frequencies and strain amplitudes have been tested by numerical simulation of the proposed model. The simulations show that neurons tend to reorient toward an equilibrium angle that falls in the experimentally observed range. Moreover, the model captures the relation between the stretching condition and the speed of reorientation. Indeed, numerical results show that neurons tend to reorient faster as the frequency and amplitude of oscillation increase
Characterisation of 6DOF natural and controlled relative dynamics in cislunar space
Full text linkAt the 50th anniversary of Apollo 11, the Moon is back to the scene of scientific and commercial space exploration interests. During the next decade, the establishment of a Gateway in cislunar non-Keplerian orbits will open the space frontiers to sustainable manned and robotic missions on and around the Moon. Such infrastructure will require several logistic operations for its assembly and maintenance, which lean on rendezvous and docking capabilities. Even if few missions have flown on non-Keplerian orbits, Rendezvous and Docking (RV&D) operations have not been performed but in Low Earth Orbit (LEO). Investigations about 6 Degrees Of Freedom (DOF) relative dynamics in non-Keplerian environment are now mandatory to highlight criticalities in the design of the cislunar gateway and to translate RV&D protocols, consolidated in LEO for the International Space Station (ISS), to the new non-Keplerian environment. In this direction, the paper analyses the 6DOF natural orbit-attitude dynamics within the Circular Restricted Three-Body Problem (CR3BP) framework. A novel perspective of the dynamical structures, constituting 6DOF manifolds, allows to better characterise the natural relative dynamics in proximity of non-Keplerian orbits. The importance of orbit-attitude manifolds exploitation is underlined for designing reliable and efficient rendezvous trajectories, enhanced by natural cislunar dynamics. Then, an ephemeris cislunar dynamical model is exploited to address guidance laws for proximity operations. The control capability is included in the dynamics of a chaser vehicle, which is employed to solve the 6DOF guidance problem in proximity of a target spacecraft. The results obtained with the controlled dynamics are compared to those available thanks to natural motion, discussing the energetic and time costs to complete the manoeuvres. A control parametrisation to solve the optimal energy rendezvous problem is proposed. Finally, a feasible operational rendezvous scenario is discussed about the identified favourable locations along the non-Keplerian orbit to perform complex proximity operations. Significant relations between RV&D time and non-Keplerian orbit’s period are discussed as well
Floquet modes and stability analysis of periodic orbit-attitude solutions along Earth–Moon halo orbits
Full text linkFuture space programmes pose some interesting research problems in the field of non-Keplerian dynamics, being the Moon and the cislunar space central in the proposed roadmap for the future space exploration. In these regards, the deployment of a cislunar space station on a non-Keplerian orbit in the lunar vicinity is a fundamental milestone to be achieved. The paper investigates the natural orbit-attitude dynamics and the attitude stabilisation of coupled motions for extended bodies in the Earth-Moon system. The discussion is carried out analysing the phase space of natural dynamics, constituted by both the orbital and the rotational periodic motions of a spacecraft in cislunar orbits. Floquet theory is applied to periodic orbit-attitude solutions in lunar proximity, to characterise their attitude stability properties and their attitude manifolds, which are discussed and analysed focusing on their dynamical features applicable to cislunar environment. Attitude stabilisation methods are proposed and developed, with particular attention to spin-stabilised solutions. Periodic orbit-attitude dynamics are studied to highlight possible favourable conditions that may be exploited to host a cislunar space station with a simplified control action. The focus of the analysis is dedicated to halo orbits and near-rectilinear halo orbit in the circular restricted three-body problem Earth-Moon system
Differentiated cell behavior: a multiscale approach using measure theory
Full text linkThis paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system. By looking at the spatial distribution of cells in terms of time-evolving measures, rather than at individual cell paths, we obtain an ensemble representation stemming from the phenomenological behavior of the single component cells. In particular, as a key advantage of our approach, the scale of representation of the system, i.e., microscopic/discrete vs. macroscopic/continuous, can be chosen a posteriori according only to the spatial structure given to the aforesaid measures. The paper focuses in particular on the use of different scales based on the specific functions performed by cells. A two-population hybrid system is considered, where cells with a specialized/differentiated phenotype are treated as a discrete population of point masses while unspecialized/undifferentiated cell aggregates are represented by a continuous approximation. Numerical simulations and analytical investigations emphasize the role of some biologically relevant parameters in determining the specific evolution of such a hybrid cell system
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