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A series of letters from Juan Colmenero to Dr. Hector P. Garcia.
No full textA series of letters from Juan Colmenero to Dr. Hector P. Garcia regarding his recent legal troubles, and including a copy of his bail bonds and a letter from President Reagan
Measuring dielectric properties at the nanoscale using Electrostatic Force Microscopy
No full textSeveral electrostatic force microscopy (EFM) - based methods have been recently developed to study the nanoscale dielectric properties of thin insulating layers. Some methods allow measuring quantitatively the static dielectric permittivity whereas some others provide qualitative information about the temperature-frequency dependence of dielectric properties. In this chapter, all these methods are described and illustrated by experiments on pure and nanostructured polymer films. A section is dedicated to EFM probe - sample models and especially to the Equivalent Charge Method (ECM)
Historiografía digital : M. Romero Recio, Mª Jesús Colmenero (eds), Historiografía digital. Proyectos para almacenar y construir la historia, (anejos de la Revista de Historiografía, 4), 2016
No full textLopez-Gomez José Carlos. Historiografía digital : M. Romero Recio, Mª Jesús Colmenero (eds), Historiografía digital. Proyectos para almacenar y construir la historia, (anejos de la Revista de Historiografía, 4), 2016. In: Dialogues d'histoire ancienne, vol. 44, n°1, 2018. pp. 334-338
Historiografía digital : M. Romero Recio, Mª Jesús Colmenero (eds), Historiografía digital. Proyectos para almacenar y construir la historia, (anejos de la Revista de Historiografía, 4), 2016
No full textLopez-Gomez José Carlos. Historiografía digital : M. Romero Recio, Mª Jesús Colmenero (eds), Historiografía digital. Proyectos para almacenar y construir la historia, (anejos de la Revista de Historiografía, 4), 2016. In: Dialogues d'histoire ancienne, vol. 44, n°1, 2018. pp. 334-338
High variability in parvalbumin beta 1 genes offers new molecular options for controlling the mislabeling in commercial Salmonids
No full textThis study was supported by the Regional Government of Asturias (Grant GRUPIN-2014-093). M. Muñoz-Colmenero holds a national Spanish Grant (reference AP-2010-5211)
Ricostruzione del labbro inferiore mediante lembo di Colmenero dopo ampia chirurgia demolitiva: una opzione affidabile
No full textCarcinoma de labios; Reconstrucción del labio inferior; Carcinoma de células escamosasLip carcinoma; Lower lip reconstruction; Squamous cell carcinomaCarcinoma de llavis; Reconstrucció del llavi inferior; Carcinoma de cèl·lules escamosesObjective. Reconstruction of the lower lip is complex. The Colmenero flap is an effective albeit rarely described method for the repair of medium- to large-sized defects of the lower lip. Methods. A retrospective review was carried out using data gathered from patients who had undergone Colmenero flap reconstruction of the lower lip at our centre between 2015 and 2020. We analysed demographic, histologic and anatomic variables as well as surgical results. This review assessed flap functionality based on proper mouth closure, absence of microstomia and oral competence.
Results. Thirteen Colmenero flaps were performed in 9 patients, with the flap being used bilaterally in four cases. All patients had squamous cell carcinoma of the lower lip. The mean length of the reconstructed defect was 4.1 cm (ranging between 3-7.5 cm). None of the flaps exhibited signs of necrosis. Five patients required minor surgical touch up during the second procedure: two for dehiscence, two for oral leakage and one for esthetic improvement. All patients had excellent functional and aesthetic final outcomes.
Conclusions. The Colmenero flap is a good resource for medium- and large-sized lower lip reconstructions due to its reliability, limited complications, and good aesthetic and functional results
Characterization of AtSLAH4, a root anion cannel involved in net chloride uptake
No full textPóster nº 27 presentado en la S-VII de la XIV Reunión de Biología Molecular de Plantas 4-6 de Julio 2018 Salamanca (España)Although generally considered a toxic anion, we have shown that besides of an essential micronutrient, Chloride (Cl-) is a beneficial macronutrient (Franco-Navarro et al. 2016). Optimal growth of plants requires the synchronic supply of both Cl- and nitrate (NO3-) molecules, but salt stress causes excessive accumulation of Cl- in leaves, which can produce ion toxicity in Cl-sensitive crops such as citrus and grapevine.
Apart from the control of stomatal closure, members of the SLAC/SLAH family of slow-type anion channels are involved in the regulation of NO3- and Cl- homeostasis in the root, including root-to-shoot transport and NO3- vs. Cl- discrimination according to environmental cues (Cubero-Font et al. 2016). AtSLAH3 mediates the loading of anions into xylem vessels, with a high discrimination of NO3- over Cl-. Under optimal growing conditions, high expression of AtSLAH1 and SLAH1/SLAH3 heteromerization increase by seven times the Cl- conductance of SLAH3. Salinity and water deficit abolish AtSLAH1 expression in an ABA-dependent manner, strongly reducing root-to-shoot translocation of Cl- under abiotic stress (Cubero-Font et al. 2016).Cubero-Font, P (2017) PhD Thesis, Universidad de Sevilla, Seville, Spain
Cubero-Font P, Maierhofer T, Jaslan J, Rosales Miguel A, Espartero J, Díaz-Rueda P, Müller Heike M, Hürter A-L, Al-Rasheid Khaled AS, Marten I, Hedrich R, Colmenero-Flores José M, Geiger D (2016). Current Biology 26 (16):2213-2220. doi:10.1016/j.cub.2016.06.045
Franco-Navarro JD, Brumos J, Rosales MA, Cubero-Font P, Talon M, Colmenero-Flores JM (2016). Journal of Experimental Botany 67(3): 873-891. doi:10.1093/jxb/erv502This work has been supported by the MINECO-FEDER grants AGL2009-08339/AGR, AGL2015-71386-R and the National Network BIO2014-56153-REDT. PC-F has been supported by the CSIC JAE-Predoc and the German Academic Exchange Service DAAD
fellowshipsN
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Tumor gene therapy using Semliki forest virus replicons
No full textA major challenge in cancer research is to design effective vaccines that can break immunological tolerance to tumor antigens. Over the past ten years several immunotherapeutic strategies aimed at modulating the patient's immune response to fight cancer have been tested in clinical trials. Recently, there has been an increase in attention in the use of recombinant viruses as vectors for the in vivo delivery of genes with immunotherapeutic properties. One such vector are replicons based on Semliki Forest virus (rSFV), which have shown efficacy as recombinant vaccines in a variety of animal models.In this thesis, the potential of rSFV replicons as recombinant vaccines for the treatment of tumors was investigated. The well-characterized murine P815 mastocytoma was chosen as a tumor model because of its resemblance to human tumors expressing shared tumor-associated antigens (TAA). Recombinant SFV particles were constructed encoding P815A, a weakly immunogenic TAA expressed by P815 tumor cells. Mice vaccinated with these particles generated strong cytotoxic T cell responses and were protected against a lethal challenge with the P815 tumor. The therapeutic efficacy of these vectors was investigated in mice bearing established P815 tumors. Injection of rSFV encoding P1A or the immunostimulatory cytokine IL12, resulted in delayed tumor progression and in several mice complete tumor eradication. The efficacy of the treatment was dependent on the size of the treated tumor and was only achieved by local intratumoral injection of the virus. In accordance with these findings, expression of a rSFV-RNA was localized exclusively in the tumor and the local draining lymph node.Further studies were conducted to address biosafety issues related. to the in vivo distribution and persistence of rSFV particles after injection by different routes. RT-PCR analysis demonstrated that, after i.v. injection, rSFV-RNA distributed to a variety of different tissues, whereas it was confined locally after i.m. and s.c. injections. Furthermore, the expression of vector RNA was transient, and no viral RNA could be detected ten days after inoculation. In addition, all tested routes of immunization generated significant levels of antigen-specific CTL responses, and tetramer analysis showed that the distribution of antigen-specific CD8+T cells correlated with the in vivo expression pattern of rSFV, with preferential homing of antigen-specific CTLs to the local lymph node after s.c. injection.The studies presented in this thesis propose an alternative immunotherapeutic strategy to treat cancer, based on the use of rSFV-replicon vectors for the in vivo expression of tumor antigens and cytokine genes.List of scientific papersI. Colmenero P, Berglund P, Kambayashi T, Biberfeld P, Liljestrom P, Jondal M (2001). "Recombinant Semliki Forest virus vaccine vectors: the route of injection determines the localization of vector RNA and subsequent T cell response" Gene Ther 8(17): 1307-14 https://pubmed.ncbi.nlm.nih.gov/11571567II. Colmenero P, Liljestrom P, Jondal M (1999). "Induction of P815 tumor immunity by recombinant Semliki Forest virus expressing the P1A gene. " Gene Ther 6(10): 1728-33 https://pubmed.ncbi.nlm.nih.gov/10516722III. Colmenero P, Chen M, Castanos-Velez E, Liljestrom P, Jondal M (2001). "Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL12 induces regression." International Journal of Cancer (In Print)</p
Long-term impacts of human harvesting on shellfish: North Iberian top shells and limpets from the Upper Palaeolithic to the present
No full textThe authors are grateful to the Museo de Arqueología de Asturias for granting permission to study part of their collections and to Prof. S.J. Hawkins for his comments on the manuscript. M. Muñoz-Colmenero holds a National Spanish Grant (reference AP-2010-5211). This study has been supported by the Regional Government of Asturias (grant number SV-PA-13-ECOEMP-41)
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