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A new paramyotonia congenita SCN4A mutation in domain I-S5 of the sodium channel suggests novel regions involved in channel inactivation.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A new mutation in a family with cold-aggravated myotonia disrupts Na+ channel inactivation
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Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A new paramyotonia congenita mutation in a novel Na+ channel region involved in inactivation
No full textLa parotite ricorrente scialectasica nell'infanzia: studio di 10 casi.
No full textTen children, ranging in age from 10 months to 4 years, presenting with recurrent parotitis, were studied.
Main symptoms on presentation were recurrent mono-orbilateral swelling of the parotid gland with mild pain , slight fever and , less frequently, anorexia and asthenia. No pus from Stensen’s duct was observed when pressure was applied to the parotid gland. In all cases sialography disclosed evident diameter changes in the intralobar ducts .
The average age of the children at the sialogram investigation
was 5 years and 8 months.
In six children humoral immunity studies we recarried out including lgG, IgA , IgM, lgE, levels, organ specific and non specific auto-antibodies and C3 complement fraction.
The cellular immunity was also investigated including E-rosette
test, EAC and membrane immunofluorescence on lymphocytes, and phagocytic activity of PMN in peripheral blood. Two children underwent parotid gland needle biopsy.
Therapy was mainly antipyretic and antibiotic; in two cases X ray therapy was employed.
As of December 1978, follow - up varied from 12 months to 8 years and 3 months. Complete healing in all patients was not observed , nor was any correlation noticed between severity of the sialogram, frequency of the parotid gland swelling and duration of the disease. Abnormal immunological data are infrequent, poorly significant and not homogeneous, and therefore the hypothesis of an immunological disorder is not supported.
The etiology of PRS is not yet clear and only symptomatic therapy is indicated at present.
It has been reported that PRS resolves spontaneously with puberty, thus supporting a conservative therapeutic approach.
The lack of correlation between the clinical picture and these
verity of the sialogram lesion is probably due to the relative
a specificity of the X-ray picture as compared to the histologic lesion. Never the less the presence of intralobar sialectasia represents a secure finding for the differential diagnosis with other diseases that may cause periodic swelling of the parotid gland
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