3,337 research outputs found
Movement, connectivity, and landscape change in the ancient Southwest: the 20th anniversary Southwest Symposium
No full textEdited by Margarte C. Nelson and Colleen StrawhackerIncludes bibliographical references and index.pt. 1. Past and present issues -- pt. 2. Landscape use and ecological change -- pt. 3. Movement and ethnogenesis -- pt. 4. Connectivity and scale
Gerald Nelson discusses article "Do roads cause deforestation?"
No full textIFPRI Senior Researcher, Gerald Nelson, discusses the article, "Do roads cause deforestation." On July 25, 2011, Nelson and co-author, Daniel Hellerstein, were honored by the AAEA with the Publication of Enduring Quality Award for this innovative 1997 publication on techniques for turning satellite imagery into economic data
Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens
No full textVanessa C. Thompson, Tanis G.W. Morris, Dawn R. Cochrane, John Cavanagh, Latif A. Wafa, Tatyana Hamilton, Shunyou Wang, Ladan Fazli, Martin E. Gleave, and Colleen C. Nelso
Lipid Isomer Compartmentalisation
No full text<p>Datasets associated with the main text figures and supplementary information for the following publication:</p>
<p>Reuben S. E. Young, Andrew P. Bowman, Kaylyn D. Tousignant, Berwyck L. J. Poad, Jennifer H. Gunter, Lisa K. Philp, Colleen C. Nelson, Shane R. Ellis, Ron M. A. Heeren, Martin C. Sadowski, Stephen J. Blanksby. Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer. bioRxiv 2021.11.01.466716; doi: https://doi.org/10.1101/2021.11.01.466716</p>
<p>Data has been divided into primary folders, with labels referring to the relevant main/SI figure. Data folders will include raw data files generated by the analytical instruments (see METHODS section within the publication for more information), text files of specific data extracts, and image file types for microscopy and MALDI-MSI.</p>
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression
No full textL-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decrease cell growth and mTORC1 signaling in prostate cancer cells. These cells maintained levels of amino acid influx through androgen receptor-mediated regulation of LAT3 expression and ATF4 regulation of LAT1 expression after amino acid deprivation. These responses remained intact in primary prostate cancer, as indicated by high levels of LAT3 in primary disease, and by increased levels of LAT1 after hormone ablation and in metastatic lesions. Taken together, our results show how prostate cancer cells respond to demands for increased essential amino acids by coordinately activating amino acid transporter pathways vital for tumor outgrowth.Qian Wang, Charles G. Bailey, Cynthia Ng, Jessamy Tiffen, Annora Thoeng, Vineet Minhas, Melanie L. Lehman, Stephen C. Hendy, Grant Buchanan, Colleen C. Nelson, John E.J. Rasko and Jeff Hols
Nelson Algren 11-05-1975
No full textGregory Fitzgerald and Jack C. Wolf Interview Nelson Algren, who at the time had been a published author for over forty years. His most notable works at this time were "The Man with the Golden Arm" and "A Walk on the Wild Side", both of which were made into films. The Session begins with Algren reading an excerpt from "Chicago: A City on the Make", a book length poem published in 1951. Fitzgerald asks Algren to tell the story of Gregorio Cortez in great detail. Algren goes on to share how Cortez had gone about evading and fooling the Texas Rangers. The conversation turns to the connection between Nelson Algren's personal story and how the Robin Hood trope would emerge in his writing. He describes his fascination with survival and some of the less than savory things he had to do to survive after he left college. He realized he could make more money writing stories than he could selling coffee and swindling individuals so he set himself up in West Texas and began writing short stories. Algren describes the quality of "Somebody in Boots" and mentions where the title comes from. Fitzgerald asks Algren to describe where he stands with academic critics and critics and general. They also explore Algren's role as a critic and Algren shares his opinions of other writers and who were and were not risk takers. The conversation turns to the description of the presentation of Algren's work on stage and on screen and the 1800's style in which his material was presented. The conversation closes with some mentions of Algren's experience with teaching and his next project.Archived web conten
Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin-6 expression
No full textInvestigation of shell and axisymmetric shell structures
No full textThe author is with the Central Electricity Research Laboratories (C. E. R. L. ) Leatherhead, of the Central Electricity Generating Board (C. E. G. B. ) In October 1974 he was registered with The City University to undertake research leading eventually to the Degree of Doctor of Philosophy. The author's research was carried out during the registration period and has also been reported in the following C. E. G. B. Publications: - 1. Nelson, R. L., VACTIL: a program to analyse the natural frequencies and mode shapes of cooling towers whilst explicitly including the effects of leg supports and foundation elasticity, C. E. G. B. pub. No. RD/L/P 10/76. 2. Nelson, R. L., and Hellewell, J. S., * Vibration tests on a 1/250th scale model of Didcot cooling tower, C. E. G. B. pub. No. RD/L/N 112/76. (The first author was a supervisor to the second author who was a pre-university vacation trainee. The first author was a co-worker during the project; also he commissioned the apparatus, planned the experiment and wrote the paper. ) 3. Nelson, R. L1., Stress matrix for a doubly curved shell finite element, C. E. G. B. pub. No. RD/L/N 113/76 4. Nelson, R. L1., A new algorithm to program the element matrices of doubly curved shell finite elements, C. E. G. B. pub. No. RD/L/N 139/77 5. Nelson, R. Ll., Free vibration analysis of cooling towers with leg-supports by a finite element method, C. E. C. B. pub. No. RD/L/R 1935 6. Nelson, R. Ll., Proposals for improved doubly curved shell finite elements, C. E. G. B. pub. No. RD/L/N 140/77 7. Nelson, R. L1., RESAP: a program to calculate the resonant stresses, frequencies and mode shapes of axisymmetric structures, C. E. G. B. pub. No. RD/L/P 9/77. 8. Nelson, R. L1., VACTILo2: a program to calculate the frequencies, mode shapes and stresses of shell structures, C. E. G. B. pub. No. RD/L/P /77. 9. Nelson, R. L1., Calculation of stresses mode shapes and frequencies of shell structures using doubly-curved finite elements, C. E. G. B. pub. No. RD/L/N _187/77. No part of this thesis, in whole or in part, has been submitted elsewhere for the award of a higher degree or qualification. Unless otherwise stated the work is the candidates own
The emerging role of extracellular vesicle-mediated drug resistance in cancers: Implications in advanced prostate cancer
No full textEmerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs
Transforming Power Relationships: Leadership, Risk, and Hope. IHS Political Science Series No. 135, May 2013
No full textChronic communal conflicts resemble the prisoner’s dilemma. Both communities prefer peace to war. But neither trusts the other, viewing the other’s gain as its own loss, so
potentially shared interests often go unrealized.
Achieving positive-sum outcomes from apparently zero-sum struggles requires a kind of riskembracing leadership. To succeed leaders must: a) see power relations as potentially
positive-sum; b) strengthen negotiating adversaries instead of weakening them; and c) demonstrate hope for a positive future and take great personal risks to achieve it.
Such leadership is exemplified by Nelson Mandela and F.W. de Klerk in the South African democratic transition. To illuminate the strategic dilemmas Mandela and de Klerk faced, we examine the work of Robert Axelrod, Thomas Schelling, and Josep Colomer, who highlight important dimensions of the problem but underplay the role of risk-embracing leadership. Finally we discuss leadership successes and failures in the Northern Ireland settlement and the Israeli-Palestinian conflict
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