29 research outputs found

    Management of Duodenal Ulcer

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    ATOMIC FORCE CONSTANTS IN COMPOUNDS OF SECOND AND THIRD ROW ELEMENTS

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    1^{1} R.R. Gaughan and W.T. King. J. Chem. Phys. 57, 4530 (1972).Author Institution: Department of Chemistry, Brown UniversityThe atomic force constants for a series of hydrides of second and third row elements were determined from observed spectroscopic data with the use of the frequency sum rule. These constants were found to be transferable, with reasonably good accuracy, from one molecule to another without regard to molecular geometry. The application of these force constants to the study of the electronic structure of molecules and to other problems of chemical interest will be briefly discussed

    Managing processes and information technology in mergers - the integration of finance processes and systems

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    Many companies use mergers to achieve their growth goals or target technology position. To realise synergies that justify the merger transaction, an integration of the merged companies is often necessary. Such integartion takes place across company business areas (such as finance or sales) and across the layers of management consideration, which are strategy, human resources, organisation, processes, and information technology. In merger integration techniques, there is a significant gap regarding the management of operational level issues. Yet, especially for the finance business area, an integration of processes and information technology is of high importance and often required swiftly after the merger. The author therefore presents an approach designed for managing the operational level merger in the finance business area. To close the gap in considering operational level issues, the author has developed a model for integraring finance processes and information technology of merging companies. For such model development, literature resources have been used along with merger experiences of the author, and interviews with merger experts. Validation of the developed model has been conducted by using in-depth case studies for showing the effects of applying the model. Further validation interviews have been conducted to support the generality of the approach. Accommodating the significant increase of task complexity during mergers compared to normal business operation, the presented approach focuses on managing interdependencies instead of project detail. Features of this approach comprise: An organisational proposal to settinmg up merger programme management; An interdependency model, vertically interconnecting the finance business area with strategic and organisational merger decisions, and horizontally interconnecting the finance business area with other business areas. It could be shown that the presented model improves merger integration quality by reducing complexity of merger management. The model is most applicable for larger companies, and can be used in any merger phase

    Polyunsaturated fatty acid-derived lipid mediators and T cell function

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    Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms

    Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation

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    \ua9 2023, The Author(s). Histone modifications influence the recruitment of reader proteins to chromosomes to regulate events including transcription and cell division. The idea of a histone code, where combinations of modifications specify unique downstream functions, is widely accepted and can be demonstrated in vitro. For example, on synthetic peptides, phosphorylation of Histone H3 at threonine-3 (H3T3ph) prevents the binding of reader proteins that recognize trimethylation of the adjacent lysine-4 (H3K4me3), including the TAF3 component of TFIID. To study these combinatorial effects in cells, we analyzed the genome-wide distribution of H3T3ph and H3K4me2/3 during mitosis. We find that H3T3ph anti-correlates with adjacent H3K4me2/3 in cells, and that the PHD domain of TAF3 can bind H3K4me2/3 in isolated mitotic chromatin despite the presence of H3T3ph. Unlike in vitro, H3K4 readers are still displaced from chromosomes in mitosis in Haspin-depleted cells lacking H3T3ph. H3T3ph is therefore unlikely to be responsible for transcriptional downregulation during cell division

    Mergers & Acquisitions research: A bibliometric study of top strategy journals, 2000 - 2009

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    Mergers and acquisitions (M&As) are important modes through which firms undertake their domestic and international strategies. This bibliometric review examines the extant research on M&As in the top five strategic management journals during a ten years period ? from 2000 to 2009. The 90 articles identified in these top journals denote an eclectic theoretical focus with the prevalence of four theories ? resource-based view, transaction costs, agency theory and institutional theory. We present a brief analysis of the key issues in M&A research, as well as the samples and theories more commonly used. We conclude by presenting a broad discussion comprising the methods used, the research questions investigated, the type of articles, as well as limitations and avenues for future enquiry.mergers & acquisitions; strategic management journals, bibliometric study

    Incomprehension or resistance? : the Markan disciples and the narrative logic of Mark ‎‎4:1—8:30‎

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    The characterization of the Markan disciples has been and continues to be the object of ‎much scholarly reflection and speculation. For many, the Markan author’s presentation of ‎Jesus’ disciples holds a key, if not the key, to unlocking the purpose and function of the ‎gospel as a whole. Commentators differ as to whether the Markan disciples ultimately ‎serve a pedagogical or polemical function, yet they are generally agreed that the disciples ‎in Mark come off rather badly, especially when compared to their literary counterparts in ‎Matthew, Luke, and John. This narrative-critical study considers the characterization of the Markan disciples ‎within the Sea Crossing movement (Mark 4:1–8:30). While commentators have, on the ‎whole, interpreted the disciples’ negative characterization in this movement in terms of ‎lack of faith and/or incomprehension, neither of these, nor a combination of the two, fully ‎accounts for the severity of language leveled against the disciples by the narrator (6:52) ‎and Jesus (8:17–18). Taking as its starting point an argument by Jeffrey B. Gibson (1986) ‎that the harshness of Jesus’ rebuke in Mark 8:14–21 is occasioned not by the disciples’ ‎lack of faith or incomprehension but by their active resistance to his Gentile mission, this ‎investigation uncovers additional examples of the disciples’ resistance to Gentile mission, ‎offering a better account of their negative portrayal within the Sea Crossing movement ‎and helping explain many of their other failures. In short, this study argues that in Mark 4:1–8:26, the disciples are characterized as ‎resistant to Jesus’ Gentile mission and to their participation in that mission, the chief ‎consequence being that they are rendered incapable of recognizing Jesus’ vocational ‎identity as Israel’s Messiah (Thesis A). This leads to a secondary thesis, namely, that in ‎Mark 8:27–30, Peter’s recognition of Jesus’ messianic identity indicates that the disciples ‎have finally come to accept Jesus’ Gentile mission and their participation in it (Thesis B).‎ ‎“Chapter One: Introduction” offers a selective review of scholarly treatments of ‎the Markan disciples, which shows that few scholars attribute resistance, let alone ‎purposeful resistance, to the disciples. ‎“Chapter Two: The Rhetoric of Repetition” introduces the methodological tools, ‎concepts, and perspectives employed in the study. It includes a section on narrative ‎criticism, which focuses upon the story-as-discoursed and the implied author and reader, ‎and a section on Construction Grammar, a branch of cognitive linguistics founded by ‎Charles Fillmore and further developed by Paul Danove, which focuses upon semantic ‎and narrative frames and case frame analysis. ‎“Chapter Three: The Sea Crossing Movement, Mark 4:1–8:30” addresses the ‎question of Markan structure and argues that Mark 4:1–8:30 comprises a single, unified, ‎narrative movement, whose action and plot is oriented to the Sea of Galilee and whose ‎most distinctive feature is the network of sea crossings that transport Jesus and his ‎disciples back and forth between Jewish and Gentile geopolitical spaces. Following William Freedman, “Chapter Four: The Literary Motif” introduces two ‎criteria (frequency and avoidability) for determining objectively what constitutes a ‎literary motif and provides the methodological basis and starting point for the analyses ‎performed in chapters five and six. ‎“Chapter Five: The Sea Crossing Motif” establishes and then carries out a lengthy ‎narrative analysis of the Sea Crossing motif, which is oriented around Mark’s use of ‎θάλασσα (thalassa) and πλοῖον (ploion), and “Chapter Six: The Loaves Motif” does the same for The ‎Loaves motif, oriented around Mark’s use of ἄρτος (artos). Finally, “Chapter Seven: The Narrative Logic of the Disciples ‎‎(In)comprehension” draws together all narrative, linguistic, and exegetical insights of the ‎previous chapters and offers a single coherent reading of the Sea Crossing movement that ‎establishes Theses A and B.
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