1,502 research outputs found
Collectivity, distributivity, and the interpretation of numerical expressions in child and adult language
No full textSentences containing plural numerical expressions (e.g., two boys) can give rise to two interpretations (collective and distributive), arising from the fact that their representation admits of a part-whole structure. We present the results of a series of experiments designed to explore children’s understanding of this distinction and its implications for the acquisition of linguistic expressions with number words. We show that preschoolers access both interpretations, indicating that they have the requisite linguistic and conceptual machinery to generate the corresponding representations. Furthermore, they can shift their interpretation in response to structural and lexical manipulations. However, they are not fully adult-like: unlike adults, they are drawn to the distributive interpretation, and are not yet fully aware of the lexical semantics of each and together, which should favor one or another interpretation. This research bridges a gap between a well-established body of work in cognitive psychology on the acquisition of number words and more recent work investigating children’s knowledge of the syntactic and semantic properties of sentences featuring numerical expressions.Peer reviewe
Entretiens avec Julien Gaillard
No full textEntretiens avec Julien Gaillard, locuteur du patois de Valjouffrey, en vue d'explicitation de vocabulaire, syntaxe et prononciation
Colle de linguistique (M.Sibileau)
No full textJulien Sibileau propose aux candidats admissibles à l’agrégation une colle sur l’épreuve de linguistique en zoom le jeudi 23 mai de 14h à 17h.Les candidats admissibles intéressés sont priés de se manifester par email ([email protected]), pour recevoir le sujet (seuls les 3 premiers inscrits pourront présenter). Sujet: Préparation oral de linguistique Heure: 23 mai 2024 02:00 PM Paris Rejoindre Zoom Réunion https://zoom.us/j/94478321413?pwd=cEwza1MyZjBIWDNzdExCL3BkYlRPQT09 ID de réun..
Modulation du potentiel redox et hémopathies malignes : de l'étude préclinique d'un inhibiteur des aldéhydes déshydrogénase à l'essai de phase I
No full textWe will develop this thesis in 4 steps:1) Through a paper giving our vision of the mechanisms of tumor escape to targeted therapies thanks to a preliminary approach by tumor analysis in "cell-only" technique, we hypothesize about strategic options for leukemia treatment,2) We will investigate the impact of DIMATE on immune system effectors, as immunotherapy approaches have become complementary to chemotherapies,3) We will try to understand the complex redox alterations of blast cells while identifying the mechanism of action of DIMATE. We will strive to identify new biomarkers in AML related to the redox status of leukemic cells through a large prospective cohort of AML patients, while developing companion assays for drug response,4) All of this work being the basis of the phase I clinical trial that we hope to start in late 2022 (PI and national coordinator, Pr R. Costello; CLIPP AP-HM trial manager, Dr J Colle).Nous développerons cette thèse en 4 temps :1) par un article donnant notre vision des mécanismes d’échappement tumoral aux thérapies ciblées grâce à une approche préliminaire par l’analyse tumorale en technique de « cellule seule », nous émettons des hypothèses quant aux options stratégiques de traitement des leucémies, 2) nous nous intéresserons à l’impact du DIMATE sur les effecteurs du système immunitaire, puisque les approches d’immunothérapie sont devenues à l’heure actuelle complémentaires des chimiothérapies,3) nous tenterons de comprendre les altérations redox complexes des cellules blastiques tout en identifiant le mécanisme d'action du DIMATE. Nous nous efforcerons d’'identifier de nouveaux biomarqueurs dans la LAM en relation avec le statut redox des cellules leucémiques grâce à une vaste cohorte prospective d'échantillons de patients atteints de LAM, tout en mettant au point des tests-compagnons de la réponse aux médicaments,4) l’ensemble de ce travail étant la base de l’essai clinique de phase I que nous espérons débuter fin 2021-2022 (PI et coordonateur national, Pr R. Costello ; responsable essai CLIPP AP-HM, Dr J Colle)
Redox modulation and hematological malignancies : from preclinical study of an aldehyde dehydrogenase inhibitor to phase I trial
No full textNous développerons cette thèse en 4 temps :1) par un article donnant notre vision des mécanismes d’échappement tumoral aux thérapies ciblées grâce à une approche préliminaire par l’analyse tumorale en technique de « cellule seule », nous émettons des hypothèses quant aux options stratégiques de traitement des leucémies, 2) nous nous intéresserons à l’impact du DIMATE sur les effecteurs du système immunitaire, puisque les approches d’immunothérapie sont devenues à l’heure actuelle complémentaires des chimiothérapies,3) nous tenterons de comprendre les altérations redox complexes des cellules blastiques tout en identifiant le mécanisme d'action du DIMATE. Nous nous efforcerons d’'identifier de nouveaux biomarqueurs dans la LAM en relation avec le statut redox des cellules leucémiques grâce à une vaste cohorte prospective d'échantillons de patients atteints de LAM, tout en mettant au point des tests-compagnons de la réponse aux médicaments,4) l’ensemble de ce travail étant la base de l’essai clinique de phase I que nous espérons débuter fin 2021-2022 (PI et coordonateur national, Pr R. Costello ; responsable essai CLIPP AP-HM, Dr J Colle).We will develop this thesis in 4 steps:1) Through a paper giving our vision of the mechanisms of tumor escape to targeted therapies thanks to a preliminary approach by tumor analysis in "cell-only" technique, we hypothesize about strategic options for leukemia treatment,2) We will investigate the impact of DIMATE on immune system effectors, as immunotherapy approaches have become complementary to chemotherapies,3) We will try to understand the complex redox alterations of blast cells while identifying the mechanism of action of DIMATE. We will strive to identify new biomarkers in AML related to the redox status of leukemic cells through a large prospective cohort of AML patients, while developing companion assays for drug response,4) All of this work being the basis of the phase I clinical trial that we hope to start in late 2022 (PI and national coordinator, Pr R. Costello; CLIPP AP-HM trial manager, Dr J Colle)
Modulation du potentiel redox et hémopathies malignes : de l'étude préclinique d'un inhibiteur des aldéhydes déshydrogénase à l'essai de phase I
No full textWe will develop this thesis in 4 steps:1) Through a paper giving our vision of the mechanisms of tumor escape to targeted therapies thanks to a preliminary approach by tumor analysis in "cell-only" technique, we hypothesize about strategic options for leukemia treatment,2) We will investigate the impact of DIMATE on immune system effectors, as immunotherapy approaches have become complementary to chemotherapies,3) We will try to understand the complex redox alterations of blast cells while identifying the mechanism of action of DIMATE. We will strive to identify new biomarkers in AML related to the redox status of leukemic cells through a large prospective cohort of AML patients, while developing companion assays for drug response,4) All of this work being the basis of the phase I clinical trial that we hope to start in late 2022 (PI and national coordinator, Pr R. Costello; CLIPP AP-HM trial manager, Dr J Colle).Nous développerons cette thèse en 4 temps :1) par un article donnant notre vision des mécanismes d’échappement tumoral aux thérapies ciblées grâce à une approche préliminaire par l’analyse tumorale en technique de « cellule seule », nous émettons des hypothèses quant aux options stratégiques de traitement des leucémies, 2) nous nous intéresserons à l’impact du DIMATE sur les effecteurs du système immunitaire, puisque les approches d’immunothérapie sont devenues à l’heure actuelle complémentaires des chimiothérapies,3) nous tenterons de comprendre les altérations redox complexes des cellules blastiques tout en identifiant le mécanisme d'action du DIMATE. Nous nous efforcerons d’'identifier de nouveaux biomarqueurs dans la LAM en relation avec le statut redox des cellules leucémiques grâce à une vaste cohorte prospective d'échantillons de patients atteints de LAM, tout en mettant au point des tests-compagnons de la réponse aux médicaments,4) l’ensemble de ce travail étant la base de l’essai clinique de phase I que nous espérons débuter fin 2021-2022 (PI et coordonateur national, Pr R. Costello ; responsable essai CLIPP AP-HM, Dr J Colle)
All together now: disentangling semantics and pragmatics with together in child and adult language
No full textThe way in which an event is packaged linguistically can be informative about the number of participants in the event and the nature of their participation. At times, however, a sentence is ambiguous, and pragmatic information weighs in to favor one interpretation over another. Whereas adults may readily know how to pick up on such cues to meaning, children – who are generally naïve to such pragmatic nuances – may diverge and access a broader range of interpretations, or one disfavored by adults. A number of cases come to us from a now well established body of research on scalar implicatures and scopal ambiguity. Here, we complement this previous work with a previously uninvestigated example of the semantic-pragmatic divide in language development arising from the interpretation of sentences with pluralities and together. Sentences such as Two boys lifted a block (together) allow for either a Collective or a Distributive interpretation (one pushing event vs. two spatio temporally coordinated events). We show experimentally that children allow both interpretations in sentences with together, whereas adults rule out the Distributive interpretation without further contextual motivation. However, children appear to be guided by their semantics in the readings they access, since they do not allow readings that are semantically barred. We argue that they are unaware of the pragmatic information adults have at their fingertips, such as the conversational implicatures arising from the presence of a modifier, the probability of its occurrence being used to signal a particular interpretation among a set of alternatives, and knowledge of the possible lexical alternatives.This is an Accepted Manuscript of an article published by Taylor & Francis in Language Acquisition on 02 July 2015, available online: http://www.tandfonline.com/doi/full/10.1080/10489223.2015.1067319.Peer reviewe
Which account of wh-/quantifier interaction should everyone adopt? A new take on a classic developmental puzzle
No full textQuantifiers are expressions that denote number and quantity. When quantifiers interact with each other or with other logical expressions in a sentence, the resulting interpretation may be ambiguous. In this paper, we focus on young chilren’s understanding of the interaction of the universal quantifiers every and each with wh-expressions (who, which) in questionsPeer reviewe
Toponymes de Valjouffrey
No full textDessins des montagnes visibles de la vallée de Valjouffrey et annotation des toponymes selon leur appelation ancienne
Léviathan: A Forgotten Nouvelle by Julien Green
No full textJulien Green's nouvelle Leviathan (1926)1 tends to merit only a few passing
references in critical works on the author. This is regrettable because this early
work in a literary output spanning the years 1920 to 1995 (at least!) can be seen to
orchestrate in embryonic form many of the themes and preoccupations which
have become permanent features of Green's landscape. It may even be considered
a microcosm of his work as a whole
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