1,539 research outputs found
Designing a Transdisciplinary Curriculum: educational reflections within the Inter-university Network “Red Latinoamericana para el cambio social y el aprendizaje emancipatorio”
No full textThe crisis that Basarab Nicolescu pointed out in his Manifesto of Transdisciplinarity (1996) highlights the need to reorganize the educational system of knowledge, starting from universities as places of support and dissemination of forms of research useful for promoting change actions in this day and age – during the era of
the Covid-19 pandemic. In fact, being closely associated with educational issues since its inception, transdisciplinarity can contribute to the development of a problematizing spirit and, therefore, help the progress of knowledge, thus allowing the creation of unexpectedly creative solutions, new possibilities, and new otherwise inaccessible horizons in fragmented and reductive visions of reality.
The contribution, developed inside the "Red Latinoamericana para el cambio social y el aprendizaje emancipatorio" following the solicitations born during the 3d World Congress of Transdisciplinarity (virtual mode), reflects on the question of responding adequately to the new educational challenges currently taking place on a global level, investigating the relationship between transdisciplinarity and the innovation of university teaching
Reliable estimation of membrane curvature for cryo-electron tomography
No full textCurvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a close-to-native state and molecular resolution. However, current curvature estimation methods cannot be applied directly to membrane segmentations in cryo-ET, as these methods cannot cope with some of the artifacts introduced during image acquisition and membrane segmentation, such as quantization noise and open borders. Here, we developed and implemented a Python package for membrane curvature estimation from tomogram segmentations, which we named PyCurv. From a membrane segmentation, a signed surface (triangle mesh) is first extracted. The triangle mesh is then represented by a graph, which facilitates finding neighboring triangles and the calculation of geodesic distances necessary for local curvature estimation. PyCurv estimates curvature based on tensor voting. Beside curvatures, this algorithm also provides robust estimations of surface normals and principal directions. We tested PyCurv and three well-established methods on benchmark surfaces and biological data. This revealed the superior performance of PyCurv not only for cryo-ET, but also for data generated by other techniques such as light microscopy and magnetic resonance imaging. Altogether, PyCurv is a versatile open-source software to reliably estimate curvature of membranes and other surfaces in a wide variety of applications. Author summary Membrane curvature plays a central role in many cellular processes like cell division, organelle shaping and membrane contact sites. While cryo-electron tomography (cryo-ET) allows the visualization of cellular membranes in 3D at molecular resolution and close-to-native conditions, there is a lack of computational methods to quantify membrane curvature from cryo-ET data. Therefore, we developed a computational procedure for membrane curvature estimation from tomogram segmentations and implemented it in a software package called PyCurv. PyCurv converts a membrane segmentation, i.e. a set of voxels, into a surface, i.e. a mesh of triangles. PyCurv uses the local geometrical information to reliably estimate the local surface orientation, the principal (maximum and minimum) curvatures and their directions. PyCurv outperforms well-established curvature estimation methods, and it can also be applied to data generated by other imaging techniques
Gram stain of a smear (A) and culture (B) from an otic swab of a dog with otitis externa, showing numerous <i>M. pachydermatis</i> cells (A) and colonies (B).
No full text<p>This species is a controversial pathogen that is now recognized as an important cause of dermatitis and otitis externa in dogs. Author: F. Javier Cabañes.</p
AMS radiocarbon dates on bone collagen of the human burials from El Collado.
No full text<p>AMS radiocarbon dates on bone collagen of the human burials from El Collado.</p
Photographs of Graves 4, 5, 6 and 13 in El Collado cemetery.
No full text<p>Photographs of Graves 4, 5, 6 and 13 in El Collado cemetery.</p
The construction of opinion in Javier Marías: rhetorical-argumentative analysis of the columns published by the author between 2009 and 2013
No full textEl presente artículo tiene como objeto de estudio las columnas escritas por Javier Marías, entre los años 2009 y 2013, en el espacio semanal La Zona Fantasma, ubicado en la última página de El País Semanal, suplemento dominical del diario El País. Para el estudio se ha recurrido a un análisis de contenido, a partir de la retórica aristotélica y su posterior renovación por Charles Perelman y Lucie Olbrechts Tyteca, expuesta en su Tratado de la argumentación. La metodología seguida ha permitido identificar las particularidades y características en cuanto a temas, enfoque, estructura y lenguaje que el autor utiliza. Cuantitativamente, se identificaron los temas, los argumentos, el léxico y las figuras literarias de cada columna, y cualitativamente, las temáticas, la construcción del Ethos del autor y la interpretación de los resultados, a la luz del contexto que
enmarca los años en los que se escriben las columnasThis article has as object of study the columns written by Javier Marías between the years 2009 and 2013 in the weekly space “La Zona Fantasma”, located in the last page of El País Semanal, a Sunday supplement in the News Paper El País. For study purposes we have used an analysis of content based on the Aristotelian Rhetoric and its posterior renovation by Charles Perelman and Lucie Olbrechts-Tyteca, exposed in their Treaty of Argumentation. The methodology followed allowed to identify the particularities and characteristics in relation to topics, approach, structure and language the author uses. The qualitative contribution consisted of the conclusions about the data obtained.
This analysis focuses on the reflection around the topics, the construction of the author´s Ethos and the interpretation of the results due to the context that frames eventually, the years the column is writte
The emergence of Mesolithic cemeteries in SW Europe: Insights from the El Collado (Oliva, Valencia, Spain) radiocarbon record
No full textLocated on the Iberian Mediterranean coast, El Collado is an open-air site where a rescue excavation was conducted over two seasons in 1987 and 1988. The archaeological work excavated a surface area of 143m2 where 14 burials were discovered, providing skeletal remains from 15 individuals. We have obtained AMS dates for 10 of the 15 individuals by means of the direct dating of human bones. The ranges of the probability distribution of the calibrated dates suggest that the cemetery was used during a long period of time (781¿1020 years at a probability of 95.4%). The new dates consequently set back the chronocultural attribution of the cemetery from the initial proposal of Late Mesolithic to an older date in the Early Mesolithic. Therefore, El Collado becomes the oldest known cemetery in the Iberian Peninsula, earlier than the numerous Mesolithic funerary contexts documented on the Atlantic façade such as the Portuguese shell-middens in the Muge and Sado Estuaries or the funerary sites on the northern Iberian coast.The radiocarbon determinations reported in this study were performed within an agreement between the Consejo Superior de Investigaciones Científicas (CSIC), the Universitat Autònoma de Barcelona and the Centro Nacional de Aceleradores-Universidad de Sevilla. The research was supported by the research groups 2009SGR-0566, 2009SGR-0734, 2014SGR-1169 and 2014SGR-1420, funded by the AGAUR-Generalitat de Catalunya. J.F.G and J.F.L. are supported by Ramon y Cajal Program (RYC-2010-06628 and RYC-2011-09363). The results have
been obtained in the framework of projects HAR2009-13494-C02-01/02, HAR2011-23149, HAR2012-38838-C02-01/02 and HAR2013-41197, financed by the Ministerio de Economía y Competitividad of Spain.Peer Reviewe
Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion
No full textPuiggros, A., Delgado, J., Rodriguez-Vicente, A., Collado, R., Aventín, A., Luño, E., Grau, J., Hernandez, J.A., Marugán, I., Ardanaz, M., González, T., Valiente, A., Osma, M., Calasanz, M.J., Sanzo, C., Carrió, A., Ortega, M., Santacruz, R., Abrisqueta, P., Abella, E., Bosch, F., Carbonell, F., Solé, F., Hernández, J.M., Espinet, B
Der mesolithische friedhof von El Collado. Neuester tand und neue esultate
No full textTrabajo presentado a la International Conference Halle, celebrada en Saale (Alemania) del 18 al 21 de septiembre de 2013.-- et al.[EN]: The archaeological site of El Collado (Oliva, Valencia), excavated between 1987 and 1988, is known as one of the most outstanding mesolithic cemeteries for defining burial practices, physical anthropological traits and paleodietary patterns in the Western Mediterranean. The funerary record is composed by 14 individual burials scattered into a reduced area. The radiocarbon chronology, based on conventional C14 dates, place the funerary activity of this site between 8690–7660 BP (9885–8345 cal BP), as published in a monograph about the site (op. cit.). Some new lines of research on this important site have recently been opened in which the human osteological, zooarchaeological and lithic assemblages are the subject of analysis by a new research team. In addition, new AMS radiocarbon
determinations, mtDNA, dental use-wear and strontium stable isotope analyses are currently in progress. Despite their preliminary nature, some of the results are given in the present
paper.[DE]: Die zwischen 1987 und 1988 ausgegrabene archäologische Fundstelle von El Collado (Oliva, Valencia) ist bekannt als einer der herausragenden mesolithischen Friedhöfe zur Definierung
von Bestattungspraktiken, physisch-anthropologischen
Merkmalen und Ernährungsmustern im westlichen
Mittelmeerraum. Der Bestand an Gräbern umfasst 14 Einzelbestattungen, die auf einem kleinen Raum verteilt waren. Die
Radiokohlenstoffchronologie, basierend auf konventionellen
14C-Daten (Aparicio Pérez 2oo8) ordnet die Bestattungsaktivitäten
auf der Fundstelle, wie in einer Monographie zur Fundstelle publiziert (op. cit.), zwischen 869o und 766o BP (9885–8345 cal BP) ein. Einige neue Forschungen wurden kürzlich an dieser wichtigen Fundstelle begonnen. Sie haben durch ein neues Forschungsteam das menschlich-osteologische, zooarchäologische
und lithische Material zum Gegenstand von Analysen. Darüberhinaus sind derzeit neue AMS-Radiokohlenstoffbestimmungen
sowie mtDNS-, Zahngebrauchs- und Analysen der stabilen
Strontiumisotope in Arbeit. Trotz ihres vorläufigen Charakters
werden in diesem Beitrag einige der Resultate vorgestellt.Peer reviewe
Perspectives of the River Plate around the time of Rosas : an analysis based upon the personal correspondence, private memoirs and published accounts of British settlers, as well as works by creole authors
No full textThis thesis draws inspiration from the emergence of cultural studies as an academic
pursuit, in addition to the current renewal of interest in the relationship between
literary works and their socio-cultural milieux, to bring together an assortment of
textual traces pertaining to the River Plate around the era of Juan Manuel de Rosas,
governor of Buenos Aires and de facto dictator of Argentina for most of the period
1829-1852. The main texts analysed range from private documents relating to two
Scottish settler families, through accounts published by British citizens with first-hand
knowledge of the region (Un inglés, Cinco años en Buenos Aires and
Beaumont, Travels in Buenos Ayres and the Adjacent Provinces), to three influential
pieces of early Argentinian literature (Echeverria's El matadero, Mármol's Amalia
and Sarmiento's Facundo). One justification of this apparently eclectic approach lies
in the prominence accorded to the incomer in the thought of liberal Platine
intellectuals, a concern evinced in their literary production.
The methodology involves examining the representation of certain
fundamental topics across this range of written artefacts, observing frequent points of
thematic convergence amongst the various texts. In this fashion, I construct an image
of the River Plate region around the Rosas period, whilst also appraising the degree
to which early British settlers matched the idealized notion of the immigrant present
in liberal creole writings.
The study is divided into four main chapters, supplemented by an
introduction, conclusion and appendix. The first chapter summarizes the historical
context of the young Platine republics; the second deals with the themes of society,
community and family, the third focuses upon religion; the fourth considers
perspectives of politics, dictatorship and civil war. The appendix consists of an
unpublished settler autobiography, a remarkable account of the tribulations faced on
a daily basis in the developing Argentina
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