196,236 research outputs found
The birth of the city and the urbanization of the ager Gallicus (fourth-first century BCE), in F. Colivicchi
No full textThe archaeological discoveries of recent years have shed new light on the genesis and development of the urban phenomenon in central Adriatic Italy and, especially, in the Agro Gallico, part of Augustan regio VI, corresponding to today's northern Marche region.
From the end of the fourth century BCE onwards, with the foundation of Sena Gallica (290-284 B.C.) - the first Roman colony on the Adriatic coast - and the deduction of the Latin colony of Ariminum (268 B.C.), the process of urbanization of this territory began and reached its maturity at the end of the first century BCE.
Intimately linked to the Roman colonisation, read as a phenomenon of migration and interaction with the indigenous peoples and not as a simple instrument of power and conquest, the process of formation and urban definition of the cities of the ager Gallicus is the result of several interconnected political, legal-administrative, socio-economic and religious actions, which are discussed and analyzed by this contribution
Un piccolo insediamento in terra peuceta Le ricerche della Scuola di Specializzazione in Archeologica di Matera a Casal Sabini di Altamura (BA)
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Sacubitril/valsartan in oncologic patients with cardiotoxicity: Another weapon in our pharmacological armory?
No full textMyocardial dysfunction and heart failure (HF), frequently described as cardiotoxicity, are the most concerning cardiovascular complications of cancer therapies, causing an increase in morbidity and mortality, even due to early discontinuation of antineoplastic drugs. Research efforts have been done to prevent and treat this phenomenon, in particular through early administration of drugs inducing renin-angiotensin-aldosterone system blockade. Sacubitril/valsartan, a combination of an angiotensin receptor blocker and a neprilysin inhibitor pro-drug, has recently represented a game changer in the scenario of treatment of HF with reduced ejection fraction. However, patients with HF induced by cancer therapy were a priori excluded from the approval study. Therefore, safety and efficacy of this drug in this special population require further investigation. Available evidence, even though only derived from case reports or observational studies, seems to confirm the promising role of this new pharmacological strategy, paving the way for the use of sacubitril/valsartan in cardio-oncology. Prevention and treatment of HF in these highly vulnerable patients is a special need to allow full oncologic treatment and improve overall survival, highlighting the need for ad hoc prospective studies
The birth of the city and the urbanization of the ager Gallicus (Fourth-First Century BCE)
No full textIl contributo sintetizza le più recenti ricerche sulla colonia di età repubblicana di Sena Gallica (la prima in Adriatico) e sul suo ager di pertinenza. Le considerazioni esposte, frutto di anni di ricerche sul campo e di scavi archeologici, hanno proposto una nuova visione d'insieme e una nuova ipotesi sulla nascita e sullo sviluppo della forma urbana di età romana lungo le coste adriatiche
Screening and management of dyslipidemia in oncologic patients undergoing cardiotoxic therapies: results from an Italian survey
No full textBackground: Baseline cardiovascular risk factors correction is recommended in all cancer patients undergoing potentially cardiotoxic therapies. Despite available guidelines, real-world data on dyslipidemia prevalence and management in the oncologic population are still sparse. Methods: This survey was an Italian, investigator-initiated survey initially designed and drafted by the Cardio-Oncology section of the Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), comprising 10 individual multi-choice questions and spread after validation through the ANMCO mailing list. The survey was sent to cardiologists working in cardio-oncology units and/or managing patients with cancer. Results: Our survey included 139 Italian cardiologists. The majority of them routinely ask for the baseline lipidic profile of their patients, regardless of previous clinical history and planned treatment. According to our participants, the estimated prevalence of dyslipidemia in this population is between 20% and 60%. Although this high prevalence, our results highlight that there is poor harmony in terms of scores for CV risk prediction used in clinical practice to guide drug prescription and baseline therapy optimization. On the same line, coronary artery calcium score is poorly used in this setting. At the same time, more than 30% of interrogated physicians do not prescribe adequate statin doses, even though necessary, and have uncertainties on the use of other anti-dyslipidemic drugs in this population. Conclusions: Our results highlight the necessity of strong evidences on dyslipidemia screening and management in the cancer population, as well as the need of knowledge diffusion from scientific societies to clinicians treating these patients
Prognostic implications of right-sided insular damage, cardiac autonomic derangement, and arrhythmias after acute ischemic stroke
No full textAcute stroke is associated with impairment of cardiac autonomic balance and increased incidence of arrhythmias. These abnormalities appear more relevant in the case of involvement of the right insula in the infarct area. The aim of this study was to assess the impact of right-sided insular damage, cardiac autonomic derangement, and arrhythmias on clinical outcome after acute ischemic stroke
Discontinuation of statin therapy and clinical outcome after ischemic stroke
No full textThe majority of patients with previous ischemic stroke are expected to benefit significantly from long-term statin therapy. However, discontinuation of medication therapy frequently occurs in clinical practice. The aim of this study was to assess the impact of discontinued statin therapy on clinical outcome in patients discharged after an acute ischemic stroke
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