59 research outputs found
Regional Variation in Early Modern English: The Case of the Third-Person Present Tense Singular Verb Ending in Norfolk Correspondence
No full textA well-known example of variation in Early Modern English is found in the morphology of the third-person singular present tense indicative verb. In general terms there was a gradual shift from - th to - s (e.g., pleaseth to pleases). However, previous studies such as Kytö (1993) and Nevalainen and Raumolin-Brunberg (2003) found that this shift was by no means uniform, varying by, for example, region, type of text, and author. More specifically, Nevalainen, Raumolin-Brunberg, and Trudgill (2001) analyzed the distribution of endings for the third-person singular present indicative verb in Early Modern East Anglian English, i.e., the variety of English used in the counties of Norfolk and Suffolk. However, for the final twenty-year period of their study (1660-1680), they only have four informants. This article analyzes the distribution of verb endings for a larger number of informants during this period, which marks the final stages of - th recession in East Anglian English, using letters written in Norfolk. The corpus based on these letters allows for a detailed analysis of linguistic and extralinguistic factors that influenced this distribution. Linguistic factors include the stem-final sound and verb-type ( have, do, and say are analyzed separately). Among the extralinguistic factors analyzed are the sex of the author and addressee, the level of formality, and the author’s social class. One of the informants in this study is Sir Thomas Browne. The distribution of verb endings in his correspondence makes him an outlier. His usage has led some authors to exclude his results from their analysis. The present article offers a new approach to dealing with such cases. The overall results are compared with those for other parts of England from the same period in order to identify patterns of regional variation. Finally, an analysis of correspondence for the period 1680-1750 indicates that by this time - th had more or less disappeared from Norfolk correspondence.</jats:p
Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase.
No full textA two dimensional-liquid chromatography (2D-LC) based approach was developed for the identification and quantification of histone post translational modifications in conjunction with mass spectrometry analysis. Using a bottom-up strategy, offline 2D-LC was developed using reverse phase chromatography. A porous graphitic carbon stationary phase in the first dimension and a C18 stationary phase in the second dimension interfaced with mass spectrometry was used to analyse global levels of histone post translational modifications in human primary monocyte-derived macrophages. The results demonstrated that 84 different histone peptide proteoforms, with modifications at 18 different sites including combinatorial marks were identified, representing an increase in the identification of histone peptides by 65% and 51% compared to two different 1D-LC approaches on the same mass spectrometer. The use of the porous graphitic stationary phase in the first dimension resulted in efficient separation of histone peptides across the gradient, with good resolution and is orthogonal to the online C18 reverse phase chromatography. Overall, more histone peptides were identified using the 2D-LC approach compared to conventional 1D-LC approaches. In addition, a bioinformatic pipeline was developed in-house to enable the high throughput efficient and accurate quantification of fractionated histone peptides. The automation of a section of the downstream analysis pipeline increased the throughput of the 2D-LC-MS/MS approach for the quantification of histone post translational modifications
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease
No full textBACKGROUND: Meningococcal disease occurs after colonization of the nasopharynx with Neisseria meningitidis. Surfactant protein (SP)-A and SP-D are pattern-recognition molecules of the respiratory tract that activate inflammatory and phagocytic defences after binding to microbial sugars. Variation in the genes of the surfactant proteins affects the expression and function of these molecules.METHODS: Allele frequencies of SP-A1, SP-A2, and SP-D were determined by polymerase chain reaction in 303 patients with microbiologically proven meningococcal disease, including 18 patients who died, and 222 healthy control subjects.RESULTS: Homozygosity of allele 1A1 of SP-A2 increased the risk of meningococcal disease (odds ratio [OR], 7.4; 95% confidence interval [CI], 1.3-42.4); carriage of 1A5 reduced the risk (OR, 0.3; 95% CI, 0.1-0.97). An analysis of the multiple single-nucleotide polymorphisms in SP-A demonstrated that homozygosity for alleles encoding lysine (in 1A1) rather than glutamine (in 1A5) at amino acid 223 in the carbohydrate recognition domain was associated with an increased risk of meningococcal disease (OR, 6.7; 95% CI, 1.4-31.5). Carriage of alleles encoding lysine at residue 223 was found in 61% of patients who died, compared with 35% of those who survived (OR adjusted for age, 2.9; 95% CI, 1.1-7.7). Genetic variation of SP-A1 and SP-D was not associated with meningococcal disease.CONCLUSIONS: Gene polymorphism resulting in the substitution of glutamine with lysine at residue 223 in the carbohydrate recognition domain of SP-A2 increases susceptibility to meningococcal disease, as well as the risk of death.</p
Placed Blame
No full text A persistent problem in educational policy and research concerns how social (dis)advantage is reproduced in free societies built on ideologies of equality, opportunity, and social mobility. In this article, the author examines narratives by and for incarcerated young men about how they “got caught up” in illegal activity and eventually incarcerated. Young men and adults supervising them are found to contest choice and culpability in terms of generational and spatial legacies of possibility and social (dis-)advantage. This work is significant for what it suggests about juvenile culpability—specifically, how young people and those around them contest “choice(s)” and, subsequently “blame,” in narratives about childhood and young adulthood. The author argues that historical and geographic contexts frame universes of choices and developmental pathways that are always already present in young people’s lives. In doing so, the author challenges reductive and privatized framings of youth development to suggest a more balanced and comprehensive approach to working with and educating young offenders. </jats:p
Critical Comment on the Academic Article, "Christianity as the Abrahamic Faith Re-Discovering the Meaning of Metanoia"
No full textThis academic paper deals with the discussion on the term “‘metanoia’” and its different aspects. The author Sebastian Velassery, the author of the academic paper entitled, “Christianity as the Abrahamic Faith: Re-Discovering the Meaning of ‘metanoia’ “describes „‘metanoia’" in new terms. He says without „‘metanoia’", Christian faith and Christian understanding of love cannot account for its conscientiousness and answerability to God. This academic paper is a critical study of the same
Path of Miracles: A 21st-Century Conductor’s Guide to Joby Talbot’s Choral Masterpiece
No full textThesis (D.M.A.)--University of Washington, 2021Joby Talbot’s Path of Miracles has established its place in the Western choral music canon, receiving numerous accolades from critics, audiences, and performers alike. The piece has been recorded by two of the world’s leading choral ensembles, Tenebrae conducted by Nigel Short, and Conspirare, conducted by Craig Hella Johnson. Despite the piece’s success, little has been written about Talbot or Path of Miracles in academic literature. Using primary sources, including interviews with Joby Talbot, Robert Dickinson, Gabriel Crouch, and numerous conductors, this dissertation fills in the knowledge gaps. The purpose of this document is to provide conductors a resource to assist their preparation for future performances of Path of Miracles. Of particular interest to conductors is the detailed analysis of the libretto, which illuminates the source material for many of Robert Dickinson’s references. Additionally, an International Phonetic Alphabet guide for the entire piece is included in the appendix of this document. The analysis chapters focus on the rhythmic and melodic cells found throughout Path of Miracles which comprise the structural foundation of the work. Elements of Talbot’s instrumental background are highlighted, particularly how Path of Miracles emulates a symphonic structure.
Practical considerations for performing Path of Miracles are presented, helping conductors navigate the many logistical elements required to present this piece in concert. These practical and artistic insights come not just from this author but from many notable conductors who have performed this masterpiece. Finally, the concept of audience engagement is discussed, and notable performances of Path of Miracles are presented, including more traditional concert performances, intricate interdisciplinary programs, and excerpted movements from the piece. These examples are meant to inspire conductors as they develop their own artistic vision for performing Path of Miracles.
Path of Miracles is one of the first choral masterpieces of the 21st century. One of the reasons for its success is the extra-musical elements, such as staging directions, included in the score. Just as Path of Miracles seeks to break the expectations of what choral music can be, this document seeks to expand upon a traditional conductor’s guide
Using artificial intelligence to predict NDVI/NDRE from standard RGB aerial imagery
No full textThe student, Corey Davidson, submitted this Thesis for approval on 2021-07-05 at 17:13.This Thesis was approved for publication on 2021-07-08 at 13:24.DSpace SAF Submission Ingestion Package generated from Vireo submission #16758 on 2022-01-12 at 12:52:55Made available in DSpace on 2022-01-12T22:34:55Z (GMT). No. of bitstreams: 2
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I OnlyThe growth of precision agriculture has allowed farmers access to more data and greater efficiency for their farms. With consistently tight profit margins, farmers need ways to take advantage of the advancement of technology to lower their costs or increase their revenue. One area where these advancements can prove beneficial are in the measurement of vegetation indices such as the Normalized Difference Vegetation Index (NDVI) and Normalized Difference Red Edge Index (NDRE). Currently, an expensive multispectral camera, typically attached to an Unmanned Aerial Vehicle (UAV) during flight, is required for measuring these indices. This makes obtaining NDVI and NDRE somewhat cost prohibitive for most farmers. Color maps representing these vegetation indices can be used to identify problem areas, plant health, or even places where spot applications are needed. This work demonstrates a solution to this cost issue. The solution involves the use of artificial intelligence, or more specifically, the use of a conditional Generative Adversarial Network known as Pix2Pix. By using Pix2Pix along with training data from UAV flights, this research shows the capabilities of predicting accurate NDVI and NDRE with a low-cost Red-Green-Blue (RGB) camera. This thesis explores and assesses a cost-efficient method that can accurately predict these vegetation indices, resulting in cost-savings in the range of $5000.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-08-01The student, Corey Davidson, accepted the attached license on 2021-07-05 at 17:02
A comparative study of the thermal and radiative impacts of photovoltaic canopies on pavement surface temperatures
No full textabstract: Rapid urbanization of the planet is occurring at an unprecedented pace, primarily in arid and semi-arid hot climates [Golden, J.S., 2004. The built environment induced urban heat island effect in rapidly urbanizing arid regions – a sustainable urban engineering complexity. Environ. Sci. J. Integr. Environ. Res. 1 (4), 321–349]. This growth has manifested itself as a cause of various impacts including elevated urban temperatures in comparison to rural sites known as the Urban Heat Island (UHI) effect [Oke, T.R., 1982. The energetic basis of the urban heat island. Q. J. R. Meteor. Soc. 108, 1–24]. Related are the increased demands for electric power as a result of population growth and increased need for mechanical cooling due to the UHI. In the United States, the Environmental Protection Agency has developed a three-prong approach of (1) cool pavements, (2) urban forestry and (3) cool roofs to mitigate the UHI. Researchers undertook an examination of micro scale benefits of the utilization of photovoltaic panels to reduce the thermal impacts to surface temperatures of pavements in comparison to urban forestry. The results of the research indicate that photovoltaic panels provide a greater thermal reduction benefit during the diurnal cycle in comparison to urban forestry while also providing the additional benefits of supporting peak energy demand, conserving water resources and utilizing a renewable energy source.Corresponding Author:
Jay S. Golden
Arizona State University
[email protected]
Analyzing RFID Tags in a Distributed Environment
No full textAbstractRFID technology is widely used in various areas and found to be very useful in the business which includes supply chain management. Also the amount of RFID data is very huge as well. Hence too much time is needed to get particular information from an RFID data set. This paper proposes an efficient method to manage large amount of RFID data set. Also this proposes a unique group-id for RFID tags of unique items with which we can verify the integrity of the group of items by checking the group-id written in the tag memory. Then we devise a storage scheme called MckoiDDB that can process queries in a distributed environment. Lastly we present a graph called product localization graph to represent the tag movements in supply chain management
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