43,493 research outputs found
ß-N-acetylglucosaminidase and ß-galactosidase from aleurone layers of resting wheat grains
No full textβ-N-acetylglucosamidase and β-galattosidase from aleurone layers of resting Wheat grains
No full textß-N-Acetylglucosaminidase and ß-Galactosidase from aleurone layer of resting wheat grains.
No full textA Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
WGA-binding hydrolases from the aleurone layers of resting wheat grains: Purification and characterization of the WGA-binding ß-N-acetylglucosaminidase.
No full textThe Mechanochemical Beckmann Rearrangement: An Eco-efficient "cut-and-Paste" Strategy to Design the "good Old Amide Bond"
No full textDiscovered over a century ago, Beckmann rearrangement is still today fully compliant with all the green chemistry principles and consistent with the key aspects of sustainable development. Herein, we report on a sustainable mechanochemical procedure allowing the design of new amide frameworks via an eco-efficient "cut-and-paste"process of C-C and C-N bonds on the oxime backbone. We combined inexpensive and readily available reagents, such as p-tosyl imidazole (p-Ts-Im) and oxalic acid, to prepare smoothly and in good to high yields a library of structurally different amides, including value-added marketed compounds such as ε-caprolactam and the active pharmaceutical ingredient (API) paracetamol. This solvent-free mechanochemical procedure has also been optimized and successfully extended to several ketones serving as oxime precursors
Fast implementation of iterative adaptive approach for wideband unambiguous radar detection
No full textAccepted author manuscriptMicrowave Sensing, Signals & System
Misfolding of the amyloid beta-protein: A molecular dynamics study
No full textAmyloid beta-proteins spontaneously aggregate and build plaques in the
brains of Alzheimer's disease patients. The polypeptide has been the
subject of extensive in vitro and computational research. Still, the
pathway to aggregational forms and their exact conformations remain
largely unclear. Here we present an extensive molecular dynamics
approach simulating the protein in various temperatures, pH conditions,
and with different charge states of the N- and C-termini, thus exploring
the conformational space of the protein at large. Our results show that
the protein is able to sample different conformations, many of which are
rich in beta structure content, and all characterized by a rapid loss of
helix 1 that converts into a pi-helix, while helix 2 samples random and
beta-rich structures. Moreover, a hydrophobic cluster is observed
involving Val18, Phe19, Ala21, and Gly25. The results are carefully
compared with recent NMR and spectroscopic data, and are in global
agreement with the experimental findings
The importance of chain conformational mobility during 5-exo-cyclizations of C-, N- and O-centred radicals
No full textThe author thanks the EPSRC (grant EP/I003479/1) and EaStCHEM for funding.The reaction coordinates of an archetypical set of 5-exo cyclizations of C-, N- and O-centred radicals were investigated by computational methods. G4 theory, and DFT with the um062x functional, were able to rationalise counterintuitive factors such as the 'normal' order of rate constants being: N-centredPeer reviewe
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