6,163 research outputs found
Examples of non-commutative crepant resolutions of Cohen Macaulay normal domains
No full textLet A be a Cohen-Macaulay normal domain. A non-commutative crepant resolution (NCCR) of A is an A-algebra Gamma of the form Gamma = End(A)(M), where M is a reflexive A-module, Gamma is maximal Cohen-Macaulay as an A-module and gldim(Gamma)(p) = dim A(p) for all primes P of A. We give bountiful examples of equi-characteristic Cohen-Macaulay normal local domains and mixed characteristic Cohen-Macaulay normal local domains having NCCR. We also give plentiful examples of affine Cohen-Macaulay normal domains having NCCR. (C) 2017 Elsevier Inc. All rights reserved
On two dimensional mixed characteristic rings of finite Cohen Macaulay type
No full textIn this paper we give a bountiful number of examples of two dimensional mixed characteristic rings of finite Cohen Macaulay type. For a large subclass of these examples we give a complete description of its indecomposable maximal Cohen Macaulay modules and we also compute its AR-quiver. (C) 2015 Elsevier B.V. All rights reserved
Short-term stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics
No full textFull-resolution representative data sufficient to repeat analyses for the work of: AE Wolf, MA Heinrich, IB Breinyn, TJ Zajdel, and DJ Cohen in "Short-term stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics".
Please see the _README_.txt file for explanations on contents in this Zenodo repository.
Relevant codes used in our analyses are available on Github (github.com/CohenLabPrinceton/ElectrotaxisSupracellularMemory).The paper was submitted and is currently under Peer Review as of 08/08/2021 at PNAS Journal (Proceedings of the National Academy of Sciences of the United States of America). The preprint is available at https://www.biorxiv.org/content/10.1101/2021.07.27.453602. Support for this work was provided in part by National Institute of Health Award R35 GM133574-03 and National Science Foundation CAREER Award 2046977
THE DUAL HILBERT-SAMUEL FUNCTION OF A MAXIMAL COHEN-MACAULAY MODULE
No full textLet R be a Cohen-Macaulay local ring with a canonical module omega(R). Let I be an m-primary ideal of R and M, a maximal Cohen-Macaulay R-module. We call the function n -> l (Hom(R) (M, omega(R)/In+1 omega(R))) the dual Hilbert-Samuel function of M with respect to I. By a result of Theodorescu, this function is of polynomial type. We study its first two normalized coefficients. In particular, we analyze the case when R is Gorenstein
The Hilbert function of a maximal Cohen-Macaulay module. Part II
No full textLet (A, m) be a strict complete intersection of positive dimension and let M be a maximal Cohen-Macaulay A-module with bounded Betti numbers. We prove that the Hilbert function of M is non-decreasing. We also prove an analogous statement for complete intersections of codimension two. (C) 2014 Elsevier B.V. All rights reserved
Will biological agents supplant systemic glucocorticoids as the first-line treatment for thyroid-associated ophthalmopathy?
No full textIn this article, the two authors present their opposing points of view concerning the likelihood that glucocorticoids will be replaced by newly developed biological agents in the treatment of active, moderate-to-severe thyroid-associated ophthalmopathy (TAO). TAO is a vexing, disfiguring and potentially blinding autoimmune manifestation of thyroid autoimmunity. One author expresses the opinion that steroids are nonspecific, frequently fail to improve the disease and can cause sometimes serious side effects. He suggests that glucocorticoids should be replaced as soon as possible by more specific and safer drugs, once they become available. The most promising of these are biological agents. The other author argues that glucocorticoids are proven effective and are unlikely to be replaced by biologicals. He reasons that while they may not uniformly result in optimal benefit, they have been proven effective in many reports. He remains open minded about alternative therapies such as biologicals but remains skeptical that they will replace steroids as the first-line therapy for active, moderate-to-severe TAO without head-to-head comparative clinical trials demonstrating superiority. Despite these very different points of view, both authors are optimistic about the availability of improved medical therapies for TAO, either as single agents or in combination. Further, both agree that better treatment options are needed to improve the care of our patients with active moderate-to-severe TAO
The value of silence
No full textThis is an electronic version of the article published in Theatre Journal, 54(1):85-94, 2002 March. The published article is available at http://muse.jhu.edu/journals/theatre_journal/v054/54.1eng.pdfEng, David L.The Value of Silence.Theatre Journal, 54,(1):85-94, 2002.DOI: 10.1353/tj.2002.000
Considering animals : moral convictions concerning animals and judgement on the culling of healthy animals in animal disease epidemics
No full textEnhancement of the high-magnetic field critical current density of superconducting MgB2 by proton irradiation
No full textMagnesium diboride, MgB2, has a relatively high superconducting transition temperature(1), placing it between the families of low- and high-temperature (copper oxide based) superconductors. Supercurrent flow in MgB2 is unhindered by grain boundaries(2,3), making it potentially attractive for technological applications in the temperature range 20-30 K. But in the bulk material, the critical current density (J(c)) drops rapidly with increasing magnetic field strength(4). The magnitude and field dependence of the critical current are related to the presence of structural defects that can 'pin' the quantized magnetic vortices that permeate the material, and a lack of natural defects in MgB2 may be responsible for the rapid decline of J(c) with increasing field strength(3). Here we show that modest levels of atomic disorder induced by proton irradiation enhance the pinning of vortices, thereby significantly increasing J(c) at high field strengths. We anticipate that either chemical doping or mechanical processing should generate similar levels of disorder, and so achieve performance that is technologically attractive in an economically viable way
Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications
No full textSome gene therapy applications will require simultaneous expression of multiple gene products to achieve a therapeutic effect. In this study we describe the generation and characterization of replication incompetent herpes simplex virus type 1 (HSV-1) vectors (HX86Z or HX86G) carrying distinct and independently regulated expression cassettes for five transgenes (hIL-2, hGM-CSF, hB7.1, HSV-tk and lacZ or hIFNγ). The transgenes, representing 12 kb of DNA sequence, were recombined into separate loci of a single mutant virus vector deleted for 11.6 kb of vector sequences representing portions of nine viral genes, ICP4, ICP22, ICP27, ICP47, U(L)24, U(L)41, U(L)44, U(S)10 and U(S)11. Deletion of the immediate-early genes ICP4, ICP22 and ICP27 substantially reduced vector cytotoxicity, prevented early and late viral gene expression and left intact MHC class I antigen expression. Simultaneous expression of multiple transgenes was obtained for up to 7 days in primary human melanoma cells with peak expression at 2-3 days after infection. The transgenes were chosen for their potential to function synergistically in tumor destruction and vaccine gene therapy applications, but the method and vector employed could be applied to other multigene therapy strategies. This study demonstrates the potential for engineering large transgene capacity DNA viruses such as HSV-1 for expression of multiple transgenes
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