624 research outputs found
NANOmetric BIO-Banked MSC-Derived Exosome (NANOBIOME) as a Novel Approach to Regenerative Medicine
Get PDFMesenchymal stem cells (MSCs) are well known for their great potential in clinical applications. In fact, MSCs can differentiate into several cell lineages and show paracrine behavior by releasing endogenous factors that stimulate tissue repair and modulate local immune response. Each MSC type is affected by specific biobanking issues-technical issues as well as regulatory and ethical concerns-thus making it quite tricky to safely and commonly use MSC banking for swift regenerative applications. Extracellular vesicles (EVs) include a group of 150⁻1000 nm vesicles that are released by budding from the plasma membrane into biological fluids and/or in the culture medium from varied and heterogenic cell types. EVs consist of various vesicle types that are defined with different nomenclature such as exosomes, shedding vesicles, nanoparticles, microvesicles and apoptotic bodies. Ectosomes, micro- and nanoparticles generally refer to the direct release of single vesicles from the plasma membrane. While many studies describe exosomes as deriving from multivesicular bodies, solid evidence about the origin of EVs is often lacking. Extracellular vesicles represent an important portion of the cell secretome. Their numerous properties can be used for diagnostic, prognostic, and therapeutic uses, so EVs are considered to be innovative and smart theranostic tools. The aim of this review is to investigate the usefulness of exosomes as carriers of the whole information panel characterizing the use of MSCs in regenerative medicine. Our purpose is to make a step forward in the development of the NANOmetric BIO-banked MSC-derived Exosome (NANOBIOME).</p
Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells
No full textPaisajes distópicos en la trilogía Bruna Husky de Rosa Montero
No full textNei romanzi della detective Bruna Husky, Rosa Montero si avvale di un paesaggio urbano degradato, inspirato al noto film Blade Runner. La coesistenza di elementi attuali e futuristici, permettono all’autrice di proiettare le preoccupazioni del suo presente in un Madrid distopico, a partire dal ricorso a elementi sia del romanzo poliziesco che della fantascienza.In the novels of the detective Bruna Husky, Rosa Montero uses a degraded urban landscape, inspired by the well-known film Blade Runner. The coexistence of current and futuristic elements allows the author to project the concerns of her present into a dystopian Madrid, starting from the use of elements of both hard-boiled and science fiction
Bruna.Mundim.ASN.2015
No full text<p>R Code to map data on author home country presented in Bruna and Mundim's 2015 talk at the ASN/SSB/SSE meeting in Guaruja, Brazil</p
Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) as a Novel Stem Cell Source for Regenerative Medicine Applications
Get PDFMesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications. The main issue about the clinical use of MSCs is related to the complex way to obtain them from healthy tissues; this topic has encouraged scientists to search for novel and more advantageous sources of these cells in easily accessible tissues. The oral cavity hosts several cell populations expressing mesenchymal stem cell like-features, furthermore, the access to oral and dental tissues is simple and isolation of cells is very efficient. Thus, oral-derived stem cells are highly attractive for clinical purposes. In this context, human periapical cyst mesenchymal stem cells (hPCy-MSCs) exhibit characteristics similar to other dental-derived MSCs, including their extensive proliferative potential, cell surface marker profile and the ability to differentiate into various cell types such as osteoblasts, adipocytes and neurons. Importantly, hPCy-MSCs are easily collected from the surgically removed periapical cysts; this reusing of biological waste guarantees a smart source of stem cells without any impact on the surrounding healthy tissues. In this review, we report the most interesting research topics related to hPCy-MSCs with a newsworthy discussion about the future insights. This newly discovered cell population exhibits interesting and valuable potentialities that could be of high impact in the future regenerative medicine applications
Strategic Tools in Regenerative and Translational Dentistry.
Get PDFHuman oral-derived stem cells can be easily obtained from several oral tissues, such as dental pulp, periodontal ligament, from gingiva, or periapical cysts. Due to their differentiation potential, oral-derived mesenchymal stem cells are promising for tissue engineering and regenerative medicine. The regenerative ability showed by some oral tissues strongly depends on their sleeping adult stem cell populations that are able to repair small defects and to manage local inflammation. To date, researchers are working on effective and efficient methods to ensure safe and predictable protocols to translate stem cell research into human models. In the last decades, the challenge has been to finally use oral-derived stem cells together with biomaterials or scaffold-free techniques, to obtain strategic tools for regenerative and translational dentistry. This paper aims to give a clear point of view on state of the art developments, with some exciting insights into future strategies
Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications
Get PDFTissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. In particular, the newly discovered population of mesenchymal stem cells derived from human periapical inflamed cysts (hPCy-MSCs) have showed very promising properties, including high plasticity toward bone, vascular and neural phenotypes. In this topical review, the authors described the main oral-derived stem cell populations, their most interesting characteristics and their ability towards osteogenic lineage. This review has also investigated the main clinical procedures, reported in the recent literature, involving oral derived-MSCs and biomaterials to get better bone regeneration in dental procedures. The numerous populations of mesenchymal stem cells isolated from oral tissues (DPSCs, SHEDs, PDLSCs, DFSCs, SCAPs, hPCy-MSCs) retain proliferation ability and multipotency; these features are exploited for clinical purposes, including regeneration of injured tissues and local immunomodulation; we reported on the last studies on the proper use of such MSCs within a biological niche and the proper way to storage them for future clinical use
Un dépotoir du bas Moyen Âge dans le quartier Saint-Jean à Lyon
No full textBruna Maccari-Poisson, Ein Schuttabladeplatz des Spätmittelalters im Stadtviertel Saint-Jean in Lyon.
Der Verfasser untersucht Keramikscherben, die sich in einem ehemaligen Brunnen fanden, der gegen Ende des Mittelalters zugeschiittet und als Schuttabladeplatz verwendet wurde ; acht stratigraphische Einheiten konnten ermittelt werden. Der Autor schlägt unter Anwendung von typologischen Kriterien vor, einerseits das XV. Jh., andererseits das beginnende XVI. Jh. als Entstehungszeit dieser Keramikscherben zu bestimmen. Eine zusammenfassende Übersicht der Formen läßt ihre Entwicklung während der Auffüllphasen erkennen.Bruna Maccari-Poisson : A rubbish pit from the Late Middle Ages in the Saint-Jean quarter of Lyon.
The author examines pottery found in an ancient well, filled in towards the end of the Middle Ages and then converted into a rubbish pit, in which eight stratigraphie units have been identified. Using typological criteria, the author proposes to date some of the pottery to the fifteenth century, and the rest to the early sixteenth century. A table recapitulating their forms, makes their evolution through the in filling of the pit very clear.L'auteur étudie un lot de céramiques trouvées dans un ancien puits comblé vers la fin du Moyen Age et converti en dépotoir, dans lequel huit unités stratigraphiques ont été reconnues. L'auteur, utilisant des critères typologiques, propose de dater ces céramiques, d'une part du XVe siècle, d'autre part du début du XVIe. Un tableau récapitulatif des formes fait apparaître leur évolution au cours du remplissage du dépotoir.Maccari-Poisson Bruna. Un dépotoir du bas Moyen Âge dans le quartier Saint-Jean à Lyon. In: Archéologie médiévale, tome 18, 1988. pp. 215-237
Leonardo Manrique Castañeda: una visión interdisciplinaria. 1 Año 1 (2014) enero-marzo. Rutas de Campo. Estudiosos de Guerrero: Semblanzas
No full textGrosser Lerner, Eva y Benjamín Pérez González, “Leonardo Manrique Castañeda (entrevista)”, en Martha C. Muntzel y Bruna Radelli (coords.), Homenaje a Leonardo Manrique, México, INAH, 1993, pp. 9-45.Guzmán Betancourt, Ignacio, “Bibliografía de Leonardo Manrique Castañeda”, en Martha C. Muntzel y Bruna Radelli (coords.), Homenaje a Leonardo Manrique, México, INAH, 1993, pp. 141-152.Manrique Castañeda, Leonardo, “Historia de las lenguas indígenas de México”, en Beatriz Garza Cuarón y George Baudot, Historia de la literatura mexicana. Las literaturas amerindias de México y la literatura en español del siglo XVI, México, Siglo XXI, vol. 1, 1996, pp. 51-83.Manrique, Leonardo, “El panorama de los estudios lingüísticos de Guerrero”, en Gloria Artís, Miguel Ángel Rubio y Mette Marie Wacher, Guerrero: una mirada antropológica e histórica, México, INAH, 2007, pp. 493-498.Zúñiga, Rosa María, “Reconstrucciones lingüísticas efectuadas por Leonardo Manrique”, en Martha C. Muntzel y Bruna Radelli (coords.), Homenaje a Leonardo Manrique, México, INAH, 1993, pp. 135-140
Electroendephalography data from study on neurorehabilitation after stroke
No full textElectroencephalography data collected from a study investigating the neurophysiological aspects of a neurorehabilitation protocol combining neuromodulation with transcranial direct current stimulation (tDCS) and extreme reality for people with stroke.
The generated data associated with the study are not publicly available due to ethical requirements, but are available from the corresponding author on reasonable request
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