758 research outputs found
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The role of therapeutic drug monitoring in individualised drug dosage and exposure measurement in tuberculosis and HIV co-infection
No full textThe role of suggestion in asthma. 2. Effects of a bronchoconstrictor drug on bronchial reactivity under bronchoconstrictor or bronchodilator suggestion
No full textPrevious studies have shown that suggestion may modify bronchial reactivity to both inactive diluents and pharmacologically bronchoconstrictor or dilator substances. In our study, 14 patients were subjected to two methacholine challenge tests presented, respectively, as a bronchoconstrictor or as a bronchodilator drug. Forced expiratory volumes in one second were recorded and a PD20 was determined. No significant differences were reported in PD20 values of each patient after the two kinds of suggestion
The role of suggestion in asthma. I. Effects of inactive solution on bronchial reactivity under bronchoconstrictor or bronchodilator suggestion
No full textTwenty-eight subjects affected by perennial asthma were selected in order to investigate the possibility of inducing or relieving an asthmatic attack by means of suggestion. Twenty-five were positive to methacholine challenge test and among them, eleven reacted to an ultrasonic nebulized distilled water test. The effect of suggestion on airway response was assessed by eight inhalations of normal saline at 32 °C alternately presented as a bronchoconstrictor or as a bronchodilator drug. Eight inhalations of the same diluent without any psychic stimulus were used as control test. Seven patients reacted with bronchoconstriction to both positive and negative suggestion and to control test. Further, this group of patients showed a lower methacholine PD20 when compared with the other subjects. In this study, the effects of suggestion on bronchial reactivity were not observed and bronchoconstriction belonged to an individual hyperreactivity of the airways
Management of multidrug-resistant tuberculosis in Italy.
No full textSETTING: SMIRA (Italian Study on Anti-Tuberculosis Drug Resistance) network, 46 major clinical units and 22 laboratories nationwide in Italy.OBJECTIVES: To determine the main features, adherence to WHO guidelines and the outcomes of multidrug-resistant tuberculosis (MDR-TB) patients enrolled from January 1995 to December 1999.DESIGN: Observational study, preceded by proficiency testing, according to WHO recommendations. Results were stratified by appropriate and inappropriate regimens (< three active drugs). Analysis of the outcomes was performed according to adequacy of treatment. Analysis of risk factors and factors predicting treatment outcomes was performed using univariate and multivariate analysis (level of significance P < 0.05).RESULTS: One hundred and twenty-seven MDR patients were diagnosed. The overall success rate was low (39%). Seventy per cent of cases were treated with at least three active drugs. Factors predicting treatment success were new MDR-TB cases (OR 3.45; 95%CI 1.22–9.78; P < 0.05) and treatment for ? 12 months (OR 5.03; 95%CI 1.65–15. 31; P < 0.05). Immigration and HIV infection were the main risk factors among new MDR-TB cases.CONCLUSION: The best available treatment should be provided to all newly diagnosed MDR-TB patients, avoiding the use of poorly modified regimens. MDR-TB patients should be referred to highly specialised centres
Letter to the editor: Reply to J. J. Child, Crim. L.R. 2010, 12, 924-932
No full textResponds to J.J. Child's article in this issue criticising the conclusions reach by the author in his article "The conflict between the Serious Crime Act 2007 and section 1(4)(b) Criminal Attempts Act 1981 - a missed repeal?", (Crim. L.R. 2010, 6, 483-488)
Some Comments on the Question Whether Co-occurrence Data Should Be Normalized
No full textIn a recent paper in the Journal of the American Society for Information Science and Technology, Leydesdorff and Vaughan assert that raw cocitation data should be analyzed directly, without first applying a normalization like the Pearson correlation. In this report, it is argued that there is nothing wrong with the widely adopted practice of normalizing cocitation data. One of the arguments put forward by Leydesdorff and Vaughan turns out to depend crucially on incorrect multidimensional scaling maps that are due to an error in the PROXSCAL program in SPSS.Multidimensional scaling;Author cocitation analysis;Co-occurrence data;Normalization;PROXSCAL;Pearson correlation
Some Comments on the Question Whether Co-Occurrence Data Should Be Normalized
No full textIn a recent article in JASIST, L. Leydesdorff and L. Vaughan (2006) asserted that raw cocitation data should be analyzed directly, without first applying a normalization such as the Pearson correlation. In this communication, it is argued that there is nothing wrong with the widely adopted practice of normalizing cocitation data. One of the arguments put forward by Leydesdorff and Vaughan turns out to depend crucially on incorrect multidimensional scaling maps that are due to an error in the PROXSCAL program in SPSS.multidimensional scaling;PROXSCAL;Pearson correlation;author cocitation analysis;co-occurrence data;normalization
I. Nota betreffende de bemaling van de Drentsche hoofdvaart, opgemaakt door den ingenieur van den Rijkswaterstaat dr. L.R. Wentholt: II. Nota over het proefheien van houten en ijzeren damwand te Linne, opgemaakt door den ingenieur van den Rijkswaterstaat F. Volker
No full textEisen waaraan gemalen moeten voldoen, beschrijving van de soorten gemalen, aandrijving, ontwerp en exploitatie. Prototyoe proef met ijzeren en houten damwanden bij de sluis te Linne
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