520 research outputs found
Rezension zu: Ilaria Bignamini/Clare Hornsby, Digging and Dealing in Eighteenth-Century Rome. With additional research by Irma Della Giovampaola and Jonathan Yarker (New Haven and London 2010)
No full textData of cost-optimal solutions and retrofit design methods for school renovation in a warm climate
No full textAbstract"Efficient Solutions and Cost-Optimal Analysis for Existing School Buildings" (Paolo Maria Congedo, Delia D’Agostino, Cristina Baglivo, Giuliano Tornese, Ilaria Zacà) [1] is the paper that refers to this article. It reports the data related to the establishment of several variants of energy efficient retrofit measures selected for two existing school buildings located in the Mediterranean area. In compliance with the cost-optimal analysis described in the Energy Performance of Buildings Directive and its guidelines (EU, Directive, EU 244,) [2,3], these data are useful for the integration of renewable energy sources and high performance technical systems for school renovation. The data of cost-efficient high performance solutions are provided in tables that are explained within the following sections.The data focus on the describe school refurbishment sector to which European policies and investments are directed. A methodological approach already used in previous studies about new buildings is followed (Baglivo Cristina, Congedo Paolo Maria, D׳Agostino Delia, Zacà Ilaria, 2015; IlariaZacà, Delia D’Agostino, Paolo Maria Congedo, Cristina Baglivo; Baglivo Cristina, Congedo Paolo Maria, D’Agostino Delia, Zacà Ilaria, 2015; Ilaria Zacà, Delia D’Agostino, Paolo Maria Congedo, Cristina Baglivo, 2015; Paolo Maria Congedo, Cristina Baglivo, IlariaZacà, Delia D’Agostino,2015) [4–8]. The files give the cost-optimal solutions for a kindergarten (REF1) and a nursery (REF2) school located in Sanarica and Squinzano (province of Lecce Southern Italy). The two reference buildings differ for construction period, materials and systems.The eleven tables provided contain data about the localization of the buildings, geometrical features and thermal properties of the envelope, as well as the energy efficiency measures related to walls, windows, heating, cooling, dhw and renewables. Output values of energy consumption, gas emission and costs are given for a financial and a macro-economic analysis.This data article provides 288 and 96 combinations for REF1 and REF2, respectively. The output values are obtained using the software ProCasaClima 2015v.2.0
Author Correction: Gluten consumption and inflammation affect the development of celiac disease in at-risk children
No full textThe original version of this Article contained an error in the spelling of the authors Renata Auricchio, Ilaria Calabrese, Martina Galatola, Donatella Cielo, Fortunata Carbone, Marianna Mancuso, Giuseppe Matarese, Riccardo Troncone, Salvatore Auricchio & Luigi Greco which were incorrectly given as Auricchio Renata, Calabrese Ilaria, Galatola Martina, Cielo Donatella, Carbone Fortunata, Mancuso Marianna, Matarese Giuseppe, Troncone Riccardo, Auricchio Salvatore & Greco Luigi. The original article has been corrected
Environmental policies and social impacts. Suggestions from Europeans cities
No full textAre we really sure that green and sustainable are always good for everyone? Ilaria Beretta tries to go beyond the rhetoric of sustainability to understand more deeply the interconnection between economy, society and environment in urban contexts, in the belief that only empirical research and the analysis of data can lead to a correct reading, which is as objective as possible, of the complex reality in which we live. The author, through a comparison between European and U.S. American cities, focuses in particular on policies related to climate change and land use, showing how these, if not properly monitored in their social effects, risk contributing to the tightening of social inequalities, through processes such as ecological and green gentrification. The volume is structured in three parts. In the first section, she illustrates the main European Union’s sustainability and environmental urban policies, focusing on climate change and land use strategies. The second chapter provides a conceptual framework through the environmental justice paradigm, as it applies in Europe and in U.S. Finally, the third chapter offers an empirical analysis of ecological and green gentrification processes, comparing American and European realities, and highlighting how context-specific differences can have profound effects on the manifestation (or not) of these phenomena
Iron entry in neurons and astrocytes: a link with synaptic activity
No full textIron plays a fundamental role in the development of the central nervous system (CNS) as well as in several neuronal functions including synaptic plasticity. Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Different calcium permeable channels as well as the divalent metal transporter 1 (DMT1) have been proposed to sustain NTBI entry in neurons and astrocytes even though it remains an open issue. In both cases, it emerges that the control of iron entry is tightly linked to synaptic activity. The iron-induced oxidative tone can, in physiological conditions, positively influence the calcium levels and thus the synaptic plasticity. On the other hand, an excess of iron, with the ensuing uncontrolled production of reactive oxygen species (ROS), is detrimental for neuronal survival. A protective mechanism can be played by astrocytes that, more resistant to oxidative stress, can uptake iron, thereby buffering its concentration in the synaptic environment. This competence is potentiated when astrocytes undergo activation during neuroinflammation and neurodegenerative processes. In this minireview we focus on the mechanisms responsible for NTBI entry in neurons and astrocytes and on how they can be modulated during synaptic activity. Finally, we speculate on the relevance they may have in both physiological and pathological conditions
El Tlacuache Núm. 458 (2011). 458 Año 11 (2011) marzo. El Tlacuache
No full textReflexiones sobre la migración en la Costa Chica Oaxaqueña Cuando el teléfono suena...por Alejandra A. Ramírez López. -Fronteras Lugares irreales / lugares hiperreales por Ilaria Bologna
Werner Sombart and the global society. Anticipations from a classic author of sociology
No full textThe article examines the most salient works in which the sociologist Werner Sombart saw the dimension of globality as a social element, constitutive of mo- dernity and its future. The aim is to understand the role of globality, as an idea and a phenomenon, in the constitution in all aspects of society (economic, political, cultural, anthropological). The Works to which the article refers show a global society, one that goes from the time of Sombart to the present day, as the author had already envisioned in all their potentialities and criticalities
SINTESI E ATTIVITA’ BIOLOGICA DI LIGANDI DEL RECETTORE OPPIOIDE DOP
No full textThe opioid system, constituted by MOP, DOP and KOP receptors, modulates different
physiological functions.
Most of the terapeutical drugs are able to interact with MOP and KOP receptors and are
used as analgesics. Recent scientific papers suggest the use of DOP agonists as
antidepressive, with a different way of action compared to drugs actually used in
therapy for this pathology. On the contrary, molecules with DOP antagonist activity are
able to retard tollerance development, inevitable phenomenon associated with the use of
classical MOP ligands, such as morphine. This data suggest an association between
DOP antagonists and MOP agonists for the antidolorific therapy or the develop of new
drugs able to activate MOP receptors and, at the same time, to exercise the one
occupation of DOP receptors (MOP agonists / DOP antagonists). This pharmacological
profile could be the aim of a new class of analgesics for the chronic pain therapy.
In this thesis project two new classes of opioid ligands have being developed. They are
characterized by the DOP selective pharmacophore Dmt-Tic. First of all, modification
of the amidic spacer between Dmt-Tic and a second pharmacophore with an olefinic
spacer of variable lenght has produced molecules with DOP affinity and different
pharmacological activities (agonist, partial agonist, antagonist or inverse agonist). Their
chemical and physical characteristics confer to the molecules a greater lipofilicity and a
major metabolic stability, those physicochemical properties are necessary to carry out
animals chronic studies. Secondly, Dmt-Tic C-terminal funtionalization with ortosubstituted
anilides has generally produced molecules with DOP and MOP high affinity
except compound (123), characterized by a carbossilic moiety, that has revealed an
elevated DOP selectivity.
Lastly, a new cheap synthetic way has been developed for the preparation of L-Dmt
amminoacid in a multigram scale
Friedreich ataxia-induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitor
No full textWe employed induced pluripotent stem cell (iPSC)-derived neurons obtained from Friedreich ataxia (FRDA) patients and healthy subjects, FRDA neurons and CT neurons, respectively, to unveil phenotypic alterations related to frataxin (FXN) deficiency and investigate if they can be reversed by treatments that upregulate FXN. FRDA and control iPSCs were equally capable of differentiating into a neuronal or astrocytic phenotype. FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress. Treatment with the benzamide HDAC inhibitor 109 significantly upregulated FXN expression and increased Fe-S and lipoic acid-containing protein levels, downregulated SOD2 levels, normalized LIP and ROS levels, and almost fully protected FRDA neurons from oxidative stress-mediated cell death. Our findings suggest that correction of FXN deficiency may not only stop disease progression, but also lead to clinical improvement by rescuing still surviving, but dysfunctional neurons.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Self Portrait of an Italian Historian as a Woman on the Train
No full textThirty years on from publication of her first book, and
amidst epoch-making changes to the university system, especially in Italy, the author reconstructs her own intellectual and professional
story. In this ego histoire Ilaria Porciani goes over the milestones and encounters of her working life, as well as some material and institutional career aspects of an Italian woman historian across the turn of the millennium
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