68,710 research outputs found
Design synthesis, in vitro biological evaluation and anti-biofilm activity of new beta-lactam and linezolid-like compound as potential antibacterial agents against Staphylococcus aureus infections in cystic fibrosis patients.
No full textProgetto interdisciplinare sulla progettazione e sintesi di nuovi antibiotici specifici per contrastare le infezioni da Staffilococco aureo in pazienti di fibrosi cistic
Rufloxacin once daily versus ofloxacin twice daily for treatment of complicated cystitis and upper urinary tract infections. Italian Multicentre UTI Rufloxacin Group
No full textThe efficacy and safety of rufloxacin once daily was compared with that of ofloxacin b.i.d. for therapy of complicated cystitis and upper urinary tract infections. Eighty-three patients were randomly assigned to receive rufloxacin as a loading dose of 400 mg on the first day, followed by 200 mg s.i.d., and 80 received ofloxacin 300 mg b.i.d. Both agents were administered orally for a median duration of eight days. Bacterial elimination rates after treatment were 90% for rufloxacin and 81% for ofloxacin. Half of the treatment failures occurred in patients with infections caused by uropathogens that became either less sensitive or resistant to the quinolones being studied. At a two-week follow-up, recurrences had not occurred in any of the rufloxacin patients and had occurred in 17% of the ofloxacin patients. Minor adverse reactions were reported by 12 and 13 patients, respectively. Rufloxacin once daily is as effective as ofloxacin b.i.d. for the treatment of complicated cystitis and upper urinary tract infections
Carumonam's in-vitro activity against gram-negative bacteria and its stability to their beta-lactamases
No full textThe in vitro activity of the novel monobactam carumonam (RO17-2301) was evaluated on 311 gram-negative clinical isolates in comparison to aztreonam, cefotaxime, ceftazidime, cefotetan and ceftriaxone. Carumonam showed an antibacterial potency equal to or higher than any other reference compound; in particular it was the most effective against Proteus indole positive and Klebsiella sp. Its antipseudomonal activity was comparable to that of ceftazidime and it showed, together with aztreonam, the highest activity against the Citrobacter, Enterobacter and Escherichia coli isolates. The minimal inhibitory concentrations performed on permeability altered organisms indicated that carumonam has a penetration rate comparable to aztreonam and higher than cefotetan and ceftriaxone. Carumonam demonstrated excellent stability to chromosomal and plasmid-mediated beta-lactamases and that correlated with its antibacterial activity against the producing strains and inoculum size effect
Studio dell'associazione tra carica di HPV ad alto rischio e lesioni cervicali precancerose e cancerose
No full textInterdisciplinarietà ortodonzia e protesi nell’utilizzo del Maryland Bridge
No full textScopo del lavoro: L’obiettivo di questo lavoro è sottolineare l’importanza della relazione interdisciplinare tra le diverse branche dell’odontoiatria, in particolare tra l’ortodonzia, la protesi e l’implantologia. Inoltre gli autori presentano i vantaggi estetici e funzionali dell’applicazione del Maryland Bridge negli adolescenti.
Materiali e metodi: Nel caso clinico analizzato dagli autori è stato utilizzato il Maryland Bridge, tenendo presente che la giovane età del paziente non avrebbe consentito una risoluzione protesica definitiva e che, nell’utilizzo dello stesso, i denti contigui all’elemento mancante subiscono una scarsa perdita di smalto. Le altre caratteristiche di questa perdita sono: una metodica di realizzazione poco indaginosa ed una buona potenzialità estetica. Il paziente, a causa della perdita precoce dell’11, presentava la migrazione degli elementi dentari contigui al dente mancante. E’ stata quindi fondamentale l’interdisciplinarietà tra l’ortodontista e il protesista. Il primo intervento di tipo ortodontico preprotesico è stato finalizzato al recupero dello spazio perduto, per il quale l’ortodontista ha utilizzato un’apparecchiatura fissa multibande. In seguito il protesista ha potuto realizzare il manufatto protesico.
Conclusioni: Presupposto fondamentale per l’ottimizzazione dei risultati nei casi di agenesia o perdita di elementi dentari nei giovani pazienti, è la stretta collaborazione interdisciplinare tra ortodontista, protesista e implantologo. Dopo che l’ortodontista ha effettuato l’uprighting e la preparazione del dente mancante, la funzione del Maryland Bridge è stata quella di mantenitore di spazio, permettendo così la normale crescita dei processi ossei alveolari e, a fine cura, l’inserimento di un impianto singolo e quindi di una protesi definitiva su un impianto osteointegrato.Aim of the work. The purpose of this work is to underline the importance of interdisciplinary cooperation of different dental branches, in particularly orthodontics, prosthetics and implantology in the complex rehabilitation of young patients. Besides, the authors show the esthetic and functional advantages of using Maryland Bridge in teen-agers.
Materials and methods. The Maryland Bridge, a prosthesis with two metallic flanges, has several advantages and fields of application. In the case reported, the Maryland Bridge, avoing to the young age of the patient which did not permit a final prosthesis and an implant insertion, was considered as an interesting solution, because it can be applied on the adjoining teeth with very little loss of enamel. The Maryland Bridge presents several advantages such as: high functionality, preservation of the parts concerned, simplicity in the positioning and good aesthetic results.
Discussion. Many specialists are guilty of treating from a unidisciplinary point of view, that can lead to incomplete diagnostics, improper treatment planning, and compromised results. So to achieve optimal dentofacial results, the approach to patient care should be interdisciplinary.
Conclusions. Interdisciplinary collaboration between prosthetist and orthodontist was therefore of fundamental importance. The first step (preprosthetic orthodontics) was to regain the lost space using a fixed appliance: only then the prosthetics was able to fabricate Maryland Bridge. This kind of approach permits the synergism of each different discipline’s specialized expertise and skills, into the comprehensive protocol of treatment
In vitro activity of a new quinolone, rufloxacin, against nosocomial isolates
No full textThe in vitro activity of rufloxacin (MF 934), a new broad-spectrum fluoroquinolone, was tested against 1,032 gram-positive and gram-negative clinical isolates and compared to that of five other compounds of this class. All quinolones except for ciprofloxacin had limited activity against group A and B streptococci and pneumococci (MIC 90% of 4-64 mg/l) and no activity against enterococci. Most species of the enterobacteriaceae and staphylococci were found to be sensitive to rufloxacin (MIC 90% of 0.5-8 and 2-8 mg/l). Like the other quinolones except for ciprofloxacin, rufloxacin was not active against Pseudomonas aeruginosa. The antibacterial activity of rufloxacin was affected only minimally by an increase in the bacterial inoculum or by alterations in the pH of the medium. In spite of the relatively higher MICs of rufloxacin compared to those of the other quinolones, its favorable pharmacokinetic properties may account for its good clinical efficacy
Drug development of new beta-lactam and linezolid-like compounds active against Staphylococcus aureus isolated from cystic fibrosis patients: in vitro and in vivo biological evaluation
No full textIl progetto è volto alla progettazione e sintesi di nuovi agenti antibatterici a base beta-lattamica con attività duale antibiotica ed antiossidante capaci di agire efficacemente su ceppi di Staffilococco aureo meticillino resistente e sensibile provenienti da isolati clinici di pazienti di fibrosi cistic
Characterization of polycrystalline SiC layers grown by ECR-PECVD for micro-electro-mechanical system
No full textLarge area (up to 4 inch) polycrystalline 3C-SiC films have been deposited by electron cyclotron resonance chemical vapor deposition technique. Crystalline and non-crystalline substrates such as (1 0 0) Si wafers, thermally oxidized Si wafers and Al2O3 ceramic sheets have been used, maintaining the same deposition conditions. The structural and morphological properties of the films were analyzed by means of transmission electron microscopy and X-ray diffractometry, while surface morphology was characterized by atomic force microscopy. Preliminary results on technological processes for the realization of polycrystalline SiC based micro-electro-mechanical systems are reported. © 2002 Elsevier Science B.V. All rights reserved
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