5,698 research outputs found
The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes
No full textCross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2). Prospective data are limited to microalbuminuria and no information on renal function is available to date. The present study evaluates the association between the Pro12Ala polymorphism of PPARγ2 and the progression of albuminuria and decay in glomerular filtration rate (GFR) in type 2 diabetes
SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development
No full textDespite enormous efforts have been made in the hunt for new drugs, tuberculosis (TB) still remains the first bacterial cause of mortality worldwide, causing an estimated 8.6 million new cases and 1.3 million deaths in 2012. Multi-drug resistant-TB strains no longer respond to first-line drugs and are inexorably spreading with an estimated 650 000 cases as well as extensively-drug resistant-TB strains, which are resistant to any fluoroquinolone and at least one of the second-line drugs, with 60 000 cases. Thus the discovery and development of new medicines is a major keystone for tuberculosis treatment and control. After decades of dormancy in the field of TB drug development, recent efforts from various groups have generated a promising TB drug pipeline. Several new therapeutic agents are concurrently studied in clinical trials together with much activity in the hittolead and lead optimization stages. In this article we will review the recent advances in TB drug discovery with a special focus on structure activity relationship studies of the most advanced compound classe
A 19 year follow-up of a woman with lipoprotein lipase deficiency treated with biliopancreatic diversion
No full textWe show the long-term efficacy and safety of modified biliopancreatic diversion for the treatment of LPL-deficiency. How this option compares with gene therapy is difficult to evaluate due to limited experience. Surgery may be the first option in patients in whom medical therapy is ineffective and gene therapy not applicable
A Floating Question Mark: An Interview with Sara Hawys Roberts, Author of Withdrawn Traces: Searching For The Truth About Richey Manic
No full textAn interview with Sara Hawys Roberts, co-author of 'Withdrawn Traces: Searching For The Truth About Richey Manic' about the researching and writing of this much-anticipated book about the missing Manic Street Preacher.</p
A Floating Question Mark: An Interview with Sara Hawys Roberts, Author of Withdrawn Traces: Searching For The Truth About Richey Manic
No full textAn interview with Sara Hawys Roberts, co-author of 'Withdrawn Traces: Searching For The Truth About Richey Manic' about the researching and writing of this much-anticipated book about the missing Manic Street Preacher.</p
Sara Gossett Crigler Collection - Accession 614
No full textThe Sara Gossett Crigler Collection consists of a microfiche copy of her book titled, Education For Girls And Women In Upper South Carolina Prior to 1890 with Related Miscellaneous Articles: A Compilation by Mrs. Henry Towles Crigler (Sara Gossett Crigler), self-published in Greenville, SC on April 15, 1956. This book also includes many anecdotes and reminiscences of Sara’ family including a section devoted to the slaves owned and later freed after the Civil War by her family. The book is dedicated by the author, Sara Gossett Crigler (1886-1966), to her mother Sallie Brown Gossett (1859-1942) and her aunt Mary Brown Mahon (1861-1948) who were both graduates of Williamston Female College in 1877 and 1879 respectively. The 170 page volume would be useful to anyone doing research on the education of women in South Carolina during the 19th century. The original copy is housed at the South Carolina Historical Society as SCHS 509 and was dedicated and signed by the author, “For the Charleston Library Society” on July 10, 1964.
*Please see attached Table of Contentshttps://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1527/thumbnail.jp
Materia-autore = Author-Matter
No full textThe etymology of the word author refers to an act of creation, an act of augmentation, from the Latin verb augere. Author instantiates creation, the expansion of the pre-existing. In 1967 Roland Barthes declared the death of the author in his famous essay to state once more that the crisis is that of the author as a single subjectivity and as a term that condenses prestige, undermined by the de-subjectivation strategies of automatism, fortuity and fragmentation of the historical avant-gardes, as well as by the machinic act and by the reproducibility of the second avant-gardes.
Fifty years after Barthes’ paradigmatic formula, this lack of authorship appears to be a successful brand. The ten- sions between the anomie of matter, the law that establishes authorship and the economy that makes the work pos- sible, invoke discordant perspectives. Artists make the self-destruction of their work the real work, and appeal is made for the demolition of architectures, whether by a recognised author or not, in order to re-design, or better still, re-claim the territory. Artificial intelligence consolidates its logics and its design by progressively shedding human ingenuity. The space of criticism becomes, finally, increasingly ephemeral. However, there is an acceptation of criti- cism that is, rather than an individual ‘signature’, an exploration and explanation of how design makes theory.
The binomial author-matter seeks to mark these tensions and contradictions: the featured term author is main- tained to underline the persistence of that prestigious subjectivity, at the very moment when the rhetoric of “mat- ter as an author” promises other forms of authorship
Sara Winthrop Smith letter to Frances Casement, August 14, 1887
No full textLetter written to Frances Casement from Sara Winthrop Smith of Cincinnati, Ohio, August 14, 1887. Winthrop expresses the challenges of generating support for the suffrage movement among the conservative residents of her city, and encourages the creation of clear materials that make the argument for women's suffrage to be more widely distributed.
This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888
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