566 research outputs found
L.D. Trotsky and Activity of Research and Technology Division of USSR Supreme Council of National Economy in mid-1920s
No full textThe article considers the activities of L.D. Trotsky as the head of the Research and Technology Division of the Supreme Council of National Economy of the USSR in 1925–1926. The author uses archival documents from the Fund of the Russian State Archive of Economy, documents from the Russian State Archive of Social and Political History and other sources. There is analyzed L.D. Trotsky’s contribution to the development of applied science in the USSR
The <i>Salmonella</i> Mutagenicity Assay: The Stethoscope of Genetic Toxicology for the 21st Century
No full textObjectives: According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has been central to the field of genetic toxicology since the 1970s. Here we document the paradigm shifts engendered by the assay, the validation and applications of the assay, and how the assay is a model for future in vitro toxicology assays. Data sources: We searched PubMed, Scopus, and Web of Knowledge using key words relevant to the Salmonella assay and additional genotoxicity assays. Data extraction: We merged the citations, removing duplicates, and categorized the papers by year and topic. Data synthesis: The Salmonella assay led to two paradigm shifts: that some carcinogens were mutagens and that some environmental samples (e.g., air, water, soil, food, combustion emissions) were mutagenic. Although there are > 10,000 publications on the Salmonella assay, covering tens of thousands of agents, data on even more agents probably exist in unpublished form, largely as proprietary studies by industry. The Salmonella assay is a model for the development of 21st century in vitro toxicology assays in terms of the establishment of standard procedures, ability to test various agents, transferability across laboratories, validation and testing, and structure-activity analysis. Conclusions: Similar to a stethoscope as a first-line, inexpensive tool in medicine, the Salmonella assay can serve a similar, indispensable role in the foreseeable future of 21st century toxicology.1181115151522Aguayo, S., Munoz, M.J., de la Torre, A., Roset, J., de la Pena, E., Carballo, M., Identification of organic compounds and ecotoxicological assessment of sewage treatment plants (STP) effluents (2004) Sci Total Environ, 328, pp. 69-81Ames, B.N., The detection of chemical mutagens with enteric bacteria (1971) Chemical Mutagens: Principles and Methods For their Detection, 1, pp. 267-282. , (Hollaender A, ed). 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Manifesto on Neighbourliness
No full textThe manifesto and toolkit offers a starting place for ethical creative inquiry when making work with other people or community from an institutional position, such as student, artist-in-resident, or faculty. It is in response to the author’s experience as a community practice artist who spent their undergraduate degree at Emily Carr University frustrated with the overwhelming pressure to create fast-paced, ethically questionable projects using community as subject. Manifesto on Neighbourliness: Ethics Toolkit for Creative Community Inspiration collates knowledge shared via conversation, reading assignments, making mistakes, and other forms of interdependent inquiry. Mickey L.D. Morgan explores ethics through themes such as care, mitigating violence, responsibility, while at the same time an attempt at practicing these through situating themself within the text
Computer-assisted structure-activity relationships of nitrogenous cyclic compounds tested in Salmonella assays for mutagenicity
No full textTheoretical studies of the historical development of the accounting discipline: a review and evidence
No full textMany existing studies of the development of accounting thought have either been atheoretical or have adopted Kuhn's model of scientific growth. The limitations of this 35-year-old model are discussed. Four different general neo-Kuhnian models of scholarly knowledge development are reviewed and compared with reference to an analytical matrix. The models are found to be mutually consistent, with each focusing on a different aspect of development. A composite model is proposed. Based on a hand-crafted database, author co-citation analysis is used to map empirically the entire literature structure of the accounting discipline during two consecutive time periods, 1972–81 and 1982–90. The changing structure of the accounting literature is interpreted using the proposed composite model of scholarly knowledge development
Mutagenic and carcinogenic potential of a textile azo dye processing plant effluent that impacts a drinking water source
No full textRecently a textile azo dye processing plant effluent was identified as one of the sources of mutagenic activity detected in the Cristais River, a drinking water source in Brazil [G.A. Umbuzeiro, D.A. Roubicek, C.M. Rech, M.I.Z. Sato, L.D. Claxton, Investigating the sources of the mutagenic activity found in a river using the Salmonella assay and different water extraction procedures, Chemosphere 54 (2004) 1589-1597]. Besides presenting high mutagenic activity in the Salmonella/microsome assay, the mutagenic nitro-aminoazobenzenes dyes CI Disperse Blue 373, Cl Disperse Violet 93, and CI Disperse Orange 37 [G.A. Umbuzeiro, H.S. Freeman, S.H. Warren, D.P Oliveira, Y. Terao, T. Watanabe, L.D. Claxton, the contribution of azo dyes in the mutagenic activity of the Cristais river, Chemosphere 60 (2005) 55-64] as well as benzidine, a known carcinogenic compound [T.M. Mazzo, A.A. Saczk, G.A. Umbuzeiro, M.V.B. Zanoni, Analysis of aromatic amines in surface waters receiving wastewater from textile industry by liquid chromatographic with eletrochemical detection, Anal. Lett., in press] were found in this effluent. After similar to 6 km from the discharge of this effluent, a drinking water treatment plant treats and distributes the water to a population of approximate 60,000. As shown previously, the mutagens in the DWTP intake water are not completely removed by the treatment. The water used for human consumption presented mutagenic activity related to nitro-aromatics and aromatic amines compounds probably derived from the cited textile processing plant effluent discharge [G.A. Umbuzeiro, D.A. Roubicek, C.M. Rech, M.I.Z.. Sato, L.D. Claxton, Investigating the sources of the mutagenic activity found in a river using the Salmonella assay and different water extraction procedures, Chemosphere 54 (2004) 1589-1597; G.A. Umbuzeiro, H.S. Freeman, S.H. Warren, D.P. Oliveira, Y. Terao, T. Watanabe, L.D. Claxton, the contribution of azo dyes in the multagenic activity of the Cristais river, Chemosphere 60 (2005) 55-64]. Therefore, it is important to evaluate the possible risks involved in the human consumption of this contaminated water. With that objective, one sample of the cited industrial effluent was tested for carcinogenicity in the aberrant crypt foci medium-term assay in colon of Wistar rats. The rats received the effluent in natura through drinking water at concentrations of 0.1%, 1%, and 10%. The effluent mutagenicity was also confirmed in the Salmonella/microsome assay with the strains TA98 and YG1041. There was an increased number of preneoplastic lesions in the colon of rats exposed to concentrations of 1% and 10% of the effluent, and a positive response for both Salmonella strains tested. These results indicate that the discharge of the effluent should be avoided in waters used for human consumption and show the sensitivity of the ACF crypt foci assay as an important tool to evaluate the carcinogenic potential of environmental complex mixtures. (c) 2006 Elsevier B.V. All rights reserved.Univ Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, BrazilCETESB, Cia Tecnol Saneamento Ambiental, São Paulo, BrazilUSP, Fac Ciências Farmaceut, BR-09500900 São Paulo, BrazilUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, Brazi
Biohydrogen production under hyper salinity stress by an anaerobic sequencing batch reactor with mixed culture
No full textBackground: This study investigated the effect of organic loading rate (OLR) and NaCl concentration on biohydrogen production by preheated anaerobic sludge in a lab scale anaerobic sequencing batch reactor (ASBR) fed with glucose during long time operation. Methods: During ASBR operation, the OLR was increased in steps from 0.5 to 5 g glucose/L.d and NaCl addition started at an OLR of 5 g glucose/L.d, to obtain NaCl concentrations in the reactor in the range of 0.5-30 g/L. Results: With an increasing OLR from 0.5 to 5 g glucose/L.d, the biohydrogen yield increased and reached 0.8 ± 0.4 mol H2/mol glucose at an OLR of 5 g glucose/L.d. A NaCl concentration of 0.5 g/L resulted in a higher yield of biohydrogen (1.1 ± 0.2 mol H2/mol glucose). Concentrations above 0.5 g/L NaCl led to decreasing biohydrogen yield and the lowest yield (0.3 ± 0.1 mol H2/mol glucose) was obtained at 30 g/L of NaCl. The mass balance errors for C, H, and O in all constructed stoichiometric reactions were below 5%. Conclusions: The modified Monod model indicated that r (H2)max and Ccrit values were 23.3 mL H2/g VSS/h and 119.9 g/L, respectively. Additionally, ASBR operation at high concentrations of NaCl shifted the metabolic pathway from acidogenic toward solventogenic.Sanitary Engineerin
Becoming a good host: A beginner’s guide to learning deliberative civic engagement
No full textThis article examines how Deliberative Civic Engagement (DCE) is used as a public engagement process to invite disjointed cultural communities into a shared space to engage in democratically inspired dialogue. Dialogue is sought in DCE events because it encourages reflexivity and allows for collaborative ideation processes. Collaboration among differing groups demands that DCE events are open enough to be influenced by the immediate concerns of the participants involved. In addition, openness and vulnerability are required to support deep level thinking and connection between heterogeneous identities represented.
Kevin L.D. Leaven is a recent graduate of the James Madison University’s graduate program in Communication and Advocacy.
Author\u27s note
As the COVID-19 crisis continues, social distancing is being encouraged to minimize the spread of the coronavirus. Consequently, many conversations between colleagues, friends, and family have moved online using platforms like Zoom and Google Hangouts. Digital technologies have enabled people to overcome some of the obstacles posed by this unprecedented viral event. However, merely having the technology to talk to our peers does not automatically make conversations easier. Nor does COVID-19 erase the social barriers that previously complicated our relationships. However, I believe that people are resilient and that there are ample tools available to spark meaningful discussions amongst our associates. Thus, this article serves as a primer for deliberative civic engagement, which provides one approach to facilitating constructive, informed, and decisive dialogue with others. I argue that cultivating constructive dialogue is a skill with multiple avenues for improvement. So I hope that this article will provide helpful ideas to strengthen your communication skills while encouraging you to engage in fruitful dialogue with others in your life
Traffic management and control in intelligent vehicle highway systems
No full textTraffic congestion is a problem experienced daily by most of us. Among various traffic management schemes, efficient utilisation of the existing roadside infrastructure combined with in-vehicle technologies offers a promising solution to address traffic congestion and related problems. This approach has resulted in the development of Intelligent Vehicle Highway Systems (IVHSs). An IVHS basically consists of roadside infrastructures interacting with automated intelligent vehicles (IVs) that are organised in a closely spaced groups called platoons. With platooning, more vehicles can be accommodated on the highway, thus increasing the traffic flow. In the present situation, most of the existing traffic management and control centers use conventional roadside-based control measures to improve the traffic performance. The objective of the thesis is to provide a framework and a systematic approach for integrating traffic control and management methods into the IVHS. The focus of the thesis is on combining the control capabilities offered by automated platoons with those of the roadside infrastructure. We aim at developing traffic management and control methods to be implemented at various control levels, by incorporating intelligence from and within vehicles. Thus the roadside controllers use both IV-based and conventional traffic control measures for controlling and managing platoons, such that the performance of the traffic is improved.Delft Center for Systems and ControlMechanical, Maritime and Materials Engineerin
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