1,720,977 research outputs found
Optimisation of a novel hydrogel for the treatment of cerebral aneurysms
Full text linkApproximately 1-6% of adults have a cerebral aneurysm. Treatments include clipping and coiling; however, over 20% of coiled aneurysms recur. A novel bioactive glass-alginate hydrogel has been optimised to fill the aneurysm and prevent recurrence.
For successful aneurysm embolization, the hydrogel must be injectable and set in situ, as well as meeting other design requirements, including; injectability, strength, adhesiveness, radiopacity and cytocompatibility.
The hydrogel was optimised by examining the effect alginate concentration, chemical composition and molecular weight has on the hydrogel’s properties. The glass was acid washed which improved homogeneity of the hydrogel and reduced glass agglomeration. The glass and GDL content were optimised and resulted in a hydrogel with a higher compressive strength compared to in situ gelling alginates reported in the literature. The addition of EDC and NHS improved the adhesive strength of the hydrogel without the need for cell attaching peptides. In vitro analysis showed cells can adhere and proliferate in direct contact with the hydrogel and its eluent. Proliferation was dose dependent and likely caused by silica ions and gluconic acid released. Although endothelial cells attached to the surface of the hydrogel, this was minimal. Platelet adhesion to the hydrogel was also marginal. The hydrogel was sterilised and radiopacity was improved, but with a loss in compressive strength. In vivo analysis indicated that issues occur in delivering this material into an aneurysm, though this hydrogel can be effectively used as an embolization treatment that supports the formation of a neointima layer.
This work highlights the influence each component has on the hydrogel’s properties. Although this hydrogel was optimised for the treatment of cerebral aneurysms, the hydrogel is highly tuneable and would be suitable for a range of embolic applications. This bioactive in situ gelling hydrogel would also be suitable for tissue engineering and therapeutic drug delivery
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
"Identification of Trees and Shrubs in Winter using Buds and Twigs" by Bernd Schulz, 2018. [book review]
No full textVolume: 133Start Page: 71End Page: 7
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