5,258 research outputs found

    Clarke, Doris. Doris Clarke interview, April 28, 2005.

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    This interview is part of a series of interviews collected by The Baccalieu Trail Heritage Corporation. This interview is with Doris Clarke of Victoria, NL. The interviewer is Robin Baker. The camera was operated by Darrell Barrett. The video was edited by Mike Ryan and Darrell Barrett

    Standardising Outcomes in Paediatric Clinical Trials.

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    Mike Clarke discusses a new systematic review examining studies that involved the selection of outcomes for use in paediatric clinical trials

    Introduction to Systematic Reviews

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    In this talk, from the Veterinary Evidence Today conference 2016, Mike Clarke gives an introduction to systematic reviews. <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /

    Introduction to Systematic Reviews

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    &lt;p&gt;In this talk, from the Veterinary Evidence Today conference 2016, Mike Clarke gives an introduction to systematic reviews.&lt;/p&gt;&lt;br /&gt; &lt;img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /&gt;</jats:p

    Mike Olszewski Interview, 2009

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    Mike Olszewski is a newscaster for WKSU-FM and a professor of communications at Kent State University and the University of Akron, as well as the author of several books. He was born in Cleveland in 1953. The interview discusses his childhood, racial issues, music, and the media

    Mike Olszewski Interview, 2009

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    Mike Olszewski is a newscaster for WKSU-FM and a professor of communications at Kent State University and the University of Akron, as well as the author of several books. He was born in Cleveland in 1953. The interview discusses his childhood, racial issues, music, and the media

    Dr. Mike Davison – Faculty Author Interview

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    Dr. Mike Davison, Professor of Music, discusses his documentary film, Cuba: Rhythm in Motion. This dynamic film captures the joy of making music in Cuba, an island that Dr. Davison has visited numerous times with his students. The contrasting yet intertwined histories of Cuban and American music are traced and illustrated with extensive performance footage. A DVD of Cuba: Rhythm in Motion is available in Parsons Music Library

    John Clarke and Cyril Peck test a rock surface on which the Aboriginal Wandjina figure is painted, Western Australia, 1977 [picture] /

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    Title devised by cataloguer based on accompanying information.; Part of the Australian Information Service collection.; Inscriptions: "John Clarke and Cyril Peck test a rock surface on which the Aboriginal Wandjina figure is painted"--Printed on verso.; Accompanying information.; Also available online http://nla.gov.au/nla.pic-vn6105201

    Mike Nichols Oral History

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    Oral histories created by University of Kansas students, staff and faculty as part of the Religion in Kansas Project are archived at http://hdl.handle.net/1808/12524 in KU ScholarWorks, the digital repository of the University of Kansas.Oral history interview with Mike Nichols conducted by Diana Brown at the Latte Land coffee shop in Kansas City, Kansas, on July 6, 2014. Mike is the author of The Witches’ Sabbats, taught classes on Paganism for decades, and owned The Magic Lantern occult book shop in Kansas City in the 1980s; this interview discusses those experiences. This interview was conducted for the Religion in Kansas Project as part of a summer fieldwork internship funded by the Friends of the Department of Religious Studies.Friends of the Department of Religious Studie

    Serotonin receptor antagonists for highly emetogenic chemotherapy in adults.

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    BACKGROUND: Serotonin receptor antagonists (5-HT(3) RAs) are used to control chemotherapy-induced emesis. Although they have the same general mechanism of action (blockade of serotonin receptors), they have different chemical structures and may have different effects. OBJECTIVES: To compare efficacy of different serotonin receptor antagonists (5-HT(3) RAs) in the control of acute and delayed emesis induced by highly emetogenic chemotherapy. SEARCH STRATEGY: We searched CENTRAL, the Specialised Register of the Cochrane PaPaS Group, PubMed, EMBASE, and LILACS databases. Our most recent search was in March 2009. SELECTION CRITERIA: Randomised trials comparing 5-HT(3) RAs in an adult cancer population. DATA COLLECTION AND ANALYSIS: We extracted information from the included studies on the control of acute and delayed nausea and vomiting, either as a single or a combined outcome. Where appropriate, we combined the results of similar trials. We carried out sensitivity and subgroup analyses to test the robustness of our findings. MAIN RESULTS: We included 16 randomised trials (7808 participants). Nine of the trials compared granisetron versus ondansetron. No other drug comparison was studied in more than one trial. The meta-analyses of the granisetron versus ondansetron trials found similar results for the two drugs on acute vomiting (eight trials, 4256 participants, odds ratio (OR) 0.89; 95% CI 0.78 to 1.02), acute nausea (seven trials, 4160 participants, OR 0.97; 95% CI 0.85 to 1.10), delayed vomiting (three trials, 1119 participants, OR 1.00; 95% CI 0.74 to 1.34) and delayed nausea (two trials, 1024 participants, OR 0.96; 95% CI 0.75 to 1.24). Granisetron and ondansetron showed similar effects on headache and diarrhoea, with the possible exception of less constipation associated with ondansetron.One study of 1114 participants comparing palonosetron plus dexamethasone versus granisetron plus dexamethasone showed superiority of palonosetron in controlling delayed vomiting (OR 1.45; 95% CI 1.14 to 1.85) and delayed nausea (OR 1.63; 95% CI 1.27 to 2.10). Complete response for delayed nausea and vomiting was also in favour of the combination palonosetron and dexamethasone (OR 1.63; 95% CI 1.29 to 2.07). AUTHORS' CONCLUSIONS: Ondansetron and granisetron appear to be equivalent drugs for the prevention of acute and delayed emesis following the use of highly emetogenic chemotherapy.According to one single trial the combination of palonosetron and dexamethasone was superior to granisetron and dexamethasone in controlling delayed emesis. However, more evidence is needed before palonosetron could become the candidate 5-HT(3) RA for the control of delayed emesis induced by highly emetogenic chemotherapy
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