971 research outputs found
Aromatic and antiaromatic ring currents in a molecular nanoring
No full textThis dataset accompanies the publication: M. D. Peeks, T. D. W. Claridge and H. L. Anderson, âAromatic and antiaromatic ring currents in a molecular nanoringâ, Nature, 2017, http://dx.doi.org/10.1038/nature20798 . The associated publication describes the aromaticity and antiaromaticity of a [6]-porphyrin nanoring as a function of the oxidation state of the nanoring. At the time of publication, these were the largest (anti)aromatic systems reported. The diameter of the [6]-porphyrin nanoring is 2.4 nm. The contents of this supporting dataset are described in the âDATA MAP.txtâ file
Measuring spin relaxation rates using satellite exchange NMR spectroscopy
No full textAn approach to the indirect measurement of nuclear spin relaxation rates of low‐magnetogyric ratio (γ) nuclei using the process of satellite exchange is described. The method does not require the observation of, or even the ability to provide radio‐frequency pulses to, the low‐γ nucleus, but requires this to be scalar coupled to an NMR observable nucleus, such as 31P or 1H, making it especially attractive for the study of diamagnetic transition metals. In situations where spin relaxation is dominated by chemical shift anisotropy (CSA), the determination of the longitudinal spin relaxation time constant (T1) of the metal becomes possible, as illustrated for 195Pt and 107/109Ag
Scalar cross-relaxation detected in the NOESY spectra of oxazolidines and thiazolidines
No full textAnomalous cross-peaks observed in the NOESY spectra of 2,4-disubstituted thiazolidines and oxazoli-dines that cannot be attributed to classical dipolar NOE or chemical exchange peaks have been investi-gated experimentally and computationally and shown to arise from scalar cross-relaxation of the first kind (SCRFK). This process is stimulated by the relatively slow modulation of scalar couplings, and for the systems studied arises from slow on-off proton exchange of the amino nitrogen, a process influenced by solution temperature, acidity and concentration. The mechanism is likely to be significant for many systems in which proton exchange occurs on the millisecond timescale, and misinterpretation of these cross-peaks may lead to erroneous conclusions should their true origins not be recognised
Evaluating Research Impact through Open Access to Scholarly Communication
No full textScientific research is a competitive business – in order to secure funding, promotion and tenure researchers must demonstrate their work has impact in their field. To maximise impact researchers undertake high priority research, aim to get results first, and publish in the highest impact journals. The Internet now presents a new opportunity to the scholarly author seeking higher impact: s/he can now make their work instantly accessible on the Web through author self-archiving. This growing body of open access literature (coupled with new publishing models that make journals available for-free to the reader) maximises research impact by maximising the number of people who can read it, and making it available sooner. Open access also provides a new opportunity for bibliometric research. This thesis describes the relatively recent phenomenon of open access to research literature, tools that were built to collect and analyse that literature, and the results of analyses of the effect of open access and its effect on author behaviour. It shows that articles self-archived by authors receive between 50-250% more citations, that rapid pre-printing on the Web has dramatically reduced the peak citation rate from over a year to virtually instant and how citation-impact – now widely used for evaluation – can be expanded to include a new web metric of download impact
Effects of Pharmacotherapy on Combat-Related PTSD, Anxiety, and Depression: A Systematic Review and Meta-Regression Analysis.
No full textObjectivesTo estimate the effect of pharmacotherapy on PTSD, anxiety, and depression among combat veterans; to determine whether the effects varied according to patient and intervention characteristics; and to examine differential effects of pharmacotherapy on outcomes.Materials and methodsGoogle Scholar, PILOTS, PsycINFO, PubMed, and Web of Science databases were searched through November 2014. Searches resulted in eighteen double-blind, placebo controlled trials of 773 combat veterans diagnosed with PTSD and included only validated pre- and post-intervention PTSD and anxiety or depression measures. Authors extracted data on effect sizes, moderators, and study quality. Hedges' d effect sizes were computed and random effects models estimated sampling error and population variance. The Johnson-Neyman procedure identified the critical points in significant interactions to define regions of significance.ResultsPharmacotherapy significantly reduced (Δ, 95%CI) PTSD (0.38, 0.23-0.52), anxiety (0.42, 0.30-0.54), and depressive symptoms (0.52, 0.35-0.70). The effects of SSRIs and tricyclic antidepressants on PTSD were greater than other medications independent of treatment duration. The effect of SSRIs and tricyclic antidepressants were greater than other medications up to 5.2 and 13.6 weeks for anxiety and depression, respectively. The magnitude of the effect of pharmacotherapy on concurrently-measured PTSD, anxiety, and depression did not significantly differ.ConclusionsPharmacotherapy reduced PTSD, anxiety, and depressive symptoms in combat veterans. The effects of SSRIs and tricyclic antidepressants were greater for PTSD and occurred quicker for anxiety and depression than other medications
From disulfide- to thioether-linked glycoproteins.
No full text(Chemical Presented) Strengthening the bond: The introduction of a thiol tag in combination with chemoselective ligation to form a disulfide-linked bioconjugate is a selective and useful method for site-selective protein glycosylation. The phosphine-mediated desulfurization of such glycoconjugates to their reductant-resistant thioether-linked counterparts completes a convergent, site-selective synthesis of thioether-linked glycoproteins (see scheme). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA
Supporting Refugee Children in Pennsylvania Public Schools
No full textThis study documented the lived experiences of professionals with significant background working with child refugees, in an attempt to understand how practitioners view the information, resources, and other supports required to assure child refugees’ successful physical, cognitive, social, and emotional development. An extensive review of the published research on child refugees in the Unitd States described specific international treaties, federal statutes, and state codes, addressed developmental disruptions as refugee children experience them, and explored the school experience of specific refugee cultural groups, yet revealed few reports of practitioners’ perspectives.
Accordingly, this investigation sought the views of ten school and community professionals who engage with child refugees in a medium-sized, suburban school district to determine 1) What advice would they offer to those who will serve refugee children in public schools? 2) How useful do they find background information on legal mandates and the refugee child’s experience prior to resettlement, and when is this information most beneficial? 3) How do they experience a child refugee’s developmental disruptions, and how do they prioritize work on these disruptions?
A one hour semi-structured interview addressed knowledge, skills, and practices that professionals found to be successful when working with a refugee population, along with barriers that they encountered. A three-part, twenty-six item follow-up survey asked participants to provide background information on their experiences, rate their knowledge of federal and state legal mandates and refugee cultural experiences (e.g., home country context, refugee camp conditions), and identify any developmental disruptions a refugee child presented in their setting.
Participants reported successes and barriers that were largely role specific. Several themes, however, arose across all interviews. These themes included: 1) addressing students’ language needs, 2) engaging community resources, 3) addressing school needs related to cultural context education, 4) building relational trust, 5) identifying and addressing bullying, and 6) collaborating in pursuit of common professional goals. In addition, interviewees identified motivation and transformation as personal experiences in their work with child refugees.
Findings lead to three implications, including development of comprehensive and specific state policy, recommendations for professional standards of practice, and revision to pre-service teacher and school leader curricula
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