322,854 research outputs found
Evaluation of the in vitro and in vivo antitumoral effects of the proteasome inhibitor Bortezomib in head and neck carcinoma and malignant mesothelioma
No full textLithium and proton conducting gel-type membranes
No full textWe review the characteristics and the properties of various types of gel-type, ionically conducting membranes. We have mainly investigated two classes of membranes, one characterized by lithium ion transport and the other characterized by proton conductivity. We show that the former membranes are suitable to be used as separators in advanced lithium ion plastic batteries and that the latter show good promises to be considered as alternative, new separators in polymer electrolyte fuel cells. © 2003 Elsevier B.V. All rights reserved
Comparative Response to Electroconvulsive Therapy in Medication-Resistant Bipolar I Patients With Depression and Mixed State
No full textComparative response to electroconvulsive therapy in medication-resistant bipolar I patietns with depression and mixed state
No full textCalcifications in prostate cancer: An active phenomenon mediated by epithelial cells with osteoblast-phenotype
No full textThe main aim of this study was to investigate putative correlation between the formation of prostate calcifications and the presence of cancer cells showing the ultrastructural and morphological aspects of osteoblasts. To this end, 40 prostate biopsies of prostate cancer were enrolled and investigated from histological, immunohistochemical, and ultrastructural point of view. To the best of our knowledge, this is the first study to propose a new cell type related to the ectopic calcifications in prostate tissue, the prostate osteoblast-like cells (POLCs). Although our data require further investigations about the molecular mechanisms of both POLCs Cells generation and calcification formation, this study can open new and interesting prospective in the management of prostate cancer patients. In fact, if our data will be validated in large-cohort studies, the presence of POLCs Cells and/or prostate calcifications could become a poor negative prognostic marker for cancer occurrence due to the correlation between the presence of POLCs Cells and epithelial to mesenchymal transition phenomenon
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Response to ECT in depressive subtypes and mixed state
No full textObjectives
Available literature data suggest the efficacy of electroconvulsive therapy (ECT) in a large spectrum of depressive disorders, but the results often turn-out to be in contrast with each other. We explored differences of response to ECT in unipolar depression, bipolar depression and mixed state in a sample of patients resist- ant to pharmacological treatment.
Methods
130 patients (17 with major depressive disorder (UP), 67 with major depressive episode in bipolar disorder type II (BP II), 46 with major depressive episode in bipolar disorder type I (BP I) and 50 with mixed state (MS) according to the DSM-IV crite- ria) were included in the study and treated with bilateral ECT, on a twice-a-week schedule. The patients were assessed before (baseline) and one week after the ECT course (final score), using the Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impressions scale (CGI).
Results
The four groups (UP, BP II, BP I and MS) showed a significant improvement after the ECT course with comparable response rates in all groups. Remission rate, evaluated with the CGI and the HAM-D scales, was significantly higher in UP compared to the other 3 groups.
Conclusions
ECT should not be disregarded as an effective therapeutic option for the treatment of unipolar and bipolar depressive and mixed pa- tients resistant to pharmacological treatment. MS and BP I tended to exhibit more residual agitation and psychotic features than UP
L’Indice di Capacità di Lavoro in operatori sanitari.
No full textThe Work Ability Index was used as a complementary tool for the periodical health surveillance of health care workers in order to evaluate their functional working capacity and to plan more appropriate preventive and compensatory measures. 867 health care workers of both sexes (337 men, 530 women), aged between 23 to 65 years and with a work experience from 0.5 to 48 years ere examined. They were physicians, registered and assistant nurses, biologists, technicians and clerks, working in hospital departments, ambulatory health care services, laboratories and offices. WAI proved to be "excellent" in 27.0%, "good" in 49.7%, "moderate" in 20.1% and "poor" in 3.2%. Women showed significantly lower mean WAI than men in all age groups, particularly among registered and assistant nurses. Women shift workers showed a more pronounced decrease of WAI over the years as compared to their colleagues day workers by increasing the number of illnesses suffered, WAI similarly decreased in all age groups, but less among physicians and clerks
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