1,720,995 research outputs found
Transcription and splicing in the testis of mice fed on a genetically modified-soybean diet
No full textTranscription and splicing has been studied in the testis of mice fed on a genetically modified-soybean die
Ultrastructural and immunocytochemical study of skeletal muscles in a murine model of Down syndrome
No full textDown syndrome (DS) is a genetically-based disease which, in humans, affects about 1 over 700 newborns and is due to the presence of all or part of an extra chromosome 21. Among their several pathological traits, DS subjects suffer from an altered motor coordination but, although these difficulties in motility represent a serious problem in daily life, scarce data exist in the literature on skeletal muscles in DS. This is likely due to the obvious difficulties in obtaining bioptic material from patients with DS; however, this limitation may be partly overcome using suitable animal models. The Ts65Dn mouse bearing a trisomy for a segment of chromosome 16 (i.e. the homologue of human chromosome 21) is the most extensively studied murine model of DS since displays a remarkable number of phenotypic traits expressed in the human condition, including motor dysfunctions. By combining morphometry and immunocytochemistry at transmission electron microscopy, we examined the fine structure of skeletal myofibres, with particular attention to myonuclei, in adult and late adult Ts65Dn mice and their age-matched euploid controls, with the aim to evaluate the combined effect of DS and age on skeletal muscle. Our observations demonstrated in Ts65Dn mice an irregular arrangement of myofibrils and structural alterations of mitochondria, which often occurred in large clusters instead of being lined between myofibrils. In addition, myonuclei showed morphological modifications and changes in the amount of factors involved in RNA processing
Ultrastructural analyses on tissues from mice fed on genetically modified soybean
No full textThe work describes the ultrastructural features of tissues from mice fed on genetically modified soybea
Serviços Sociais da Universidade do Porto : Cantina, Snack Bar e Residência Universitária : Pormenor de betão armado (cisterna) : B. A. 11
No full textDocumentoServiços Sociais da Universidade do Porto : Cantina, Snack Bar e Residência Universitária : Pormenor de betão armado (cisterna) : B. A. 11 / EUROPLAN, Estudos e Projectos, Lda. (...) ; SEGROPOL, Soc. de Engenharia Projectos e Obras, LDA ; TECA, Técnicos de Engenharia. - 1:20. - 1999-02. - 1 corte em 1 folha : col. N.º do desenho: 8922
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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