1,721,038 research outputs found
“Vendita di pacchetti turistici” tramite Groupon e responsabilità per l’inadempimento dei servizi promessi (Groupon package travel and liability for failure to perform the offered services)
No full textAccertamenti tecnici e decorrenza dei termini di decadenza e prescrizione nella responsabilità dell’appaltatore per gravi difetti di immobili
No full textI prodotti alimentari per sportivi nel sistema italo-europeo: inquadramento normativo e tutela del consumatore-atleta
No full textRitardo nel trasporto aereo di passeggeri, compensazione pecuniaria e risarcimento del danno non patrimoniale (Delay in the carriage by air of passengers, “right to compensation” and “compensation for non-material damage”)
No full textRegional brain susceptibility to neurodegeneration: what is the role of glial cells?
Full text linkThe main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Lampitella, Giorgia. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Virtuoso, Assunta. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Viscovo, Immacolata. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Panetsos, Fivos. Universidad Complutense de Madrid; EspañaFil: Papa, Michele. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Cirillo, Giovanni. Università degli Studi della Campania Luigi Vanvitelli; Itali
Engineering quantum computing technologies: from compact modelling to applications
Full text linkL'abstract è presente nell'allegato / the abstract is in the attachmen
Requisiti della cessione all’INPS di crediti verso la P.A. ai fini della regolarizzazione contributiva
No full textRecupero da parte dell’INPS di sgravi contributivi integranti aiuti di Stato illegittimi: natura dell’azione, termine di prescrizione e presupposti del legittimo affidamento del beneficiario
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