18,847 research outputs found
Precision nanomedicines for prostate cancer
No full textEditorial. Published online: 27 February 2018Anna Cifuentes-Rius, Lisa M Butler and Nicolas H Voelcke
Energy Transfer Photoreactivity of Alkyl Azide Derivatives in Crystals
No full textBy Justin Cifuentes, Chemistry
Advisor: Anna Gudmundsdottir
Abstract: Upon irradiation, _, _, _, and _-alkyl azides form triplet ketone excited states which undergo further energy transfers to form triplet nitrenes as the intermediates. Laser flash photolysis studies show that the lifetimes of these triplet ketones and triplet nitrenes are longer in crystals than in solution. Nanocrystal suspension studies using water as the solvent were used to study the solid state. Solid state laser flash photolysis shows that the lifetimes of these triplet ketone azides and triplet nitrenes have increased in solid state. Through these explorations, it has been proposed that the crystal lattices function to control the stability of these intermediates
Maximizing RNA loading for gene silencing using porous silicon nanoparticles
No full textGene silencing by RNA interference is a powerful technology with broad applications. However, this technology has been hampered by the instability of small interfering RNA (siRNA) molecules in physiological conditions and their inefficient delivery into the cytoplasm of target cells. Porous silicon nanoparticles have emerged as a potential delivery vehicle to overcome these limitations-being able to encapsulate RNA molecules within the porous matrix and protect them from degradation. Here, key variables were investigated that influence siRNA loading into porous silicon nanoparticles. The effect of modifying the surface of porous silicon nanoparticles with various amino-functional molecules as well as the effects of salt and chaotropic agents in facilitating siRNA loading was examined. Maximum siRNA loading of 413 μg/(mg of porous silicon nanoparticles) was found when the nanoparticles were modified by a fourth generation polyamidoamine dendrimer. Low concentrations of urea or salt increased loading capacity: an increase in RNA loading by 19% at a concentration of 0.05 M NaCl or 21% at a concentration of 0.25 M urea was observed when compared to loading in water. Lastly, it was demonstrated that dendrimer-functionalized nanocarriers are able to deliver siRNA against ELOVL5, a target for the treatment of advanced prostate cancer.Terence Tieu, Sameer Dhawan, V. Haridas, Lisa M. Butler, Helmut Thissen, Anna Cifuentes-Rius, Nicolas H. Voelcke
El crepuscle de la filosofia
No full textEn el número 70 de la revista L'Espill trobaràs un dossier monogràfic sobre "El poder de les idees", amb contribucions de Blanca Garcés, Anna I. López, Marc Borràs, María José Murgui, José R. Ruiz Tamarit, Antonio Cubel, Mercè Rius, Rosa Mascarell, Antoni Martí Monterde i Adéla Kotátková, així com Cartes de Joan Fuster a Joan Sales, Josep M. Castellet, Santiago Albertí, Jordi Pujol i Montserrat Roig i una conversa amb Xavier Antich, per Francesc Viadel
El curs dels rius: La Tordera
No full textGrup de Recerca Medi Ambient i Tecnologies de la Informació GeogràficaLa Tordera és un dels rius més oblidats i maltractats de Catalunya, malgrat ésser-ne un dels més important
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
La promesa traicionada de la Europa social: del pleno empleo a la empleabilidad. Una mirada desde los paises del Sur Europa
No full textAnna Giulia Ingellis y Domenico Maddaloni reflexionan sobre la traición que el desmantelamiento de la Europa social ha supuesto para sus ciudadanos/as. Los autores identifican la base del creciente descontento hacia el proyecto europeo en la transformación de sus horizontes en términos de empleo. La gestión neoliberal predominante de la Gran Recesión que hemos vivido en la última década ha evaporado la vieja promesa europea de fortalecer los derechos sociales de sus ciudadanos/as teniendo como principal síntoma la defensa de la empleabilidad ante la garantía del pleno empleo. Según los autores, la responsabilización del individuo para su posición en el mercado laboral, en estos tiempos particularmente turbulentos, ha contribuido firmemente al crecimiento de una profunda desconfianza entre los ciudadanos/as hacia el papel beneficioso que Europa puede desempeñar en sus condiciones de vida
Increasing data completeness in synchrotron tts-microdiffraction experiments for δ-recycling phasing of low-symmetry compounds
No full textSuccessful phasing of synchrotron through-the-substrate microdiffraction data by δ-recycling direct-methods largely depends on the number of missing intensities caused by the limited sample rotation range [J. Rius, Direct phasing from Patterson syntheses by δ recycling. Acta Cryst. A 2012, 68, 77–81]. Particularly, for the unfavorable triclinic system, dataset completeness resulting from a single series of consecutive ϕ-scans covering a total ϕ interval of ±35° is around 41%. This value is not enough for the routinary solution of a crystal structure by δ-recycling but can be increased by ~29% by applying the orthogonal χ strategy consisting of merging the information of two series of orthogonal ϕ-scans collected at the same microvolume of the polished thin section. Test calculations using simulated and experimental tts-data of the triclinic mineral axinite confirm that, with the help of the orthogonal χ strategy, crystal structures can be solved routinely. Since data in the ±35 ϕ-interval are normally accessible even for relatively thick glass-substrates (1–1.5 mm), a crystal structure can be determined from a single microvolume. For high-symmetry phases, due to the Laue symmetry redundancy, a single series of ϕ-scans normally suffices for the application of δ-recycling. However, when for experimental causes this series is incomplete, the orthogonal χ strategy also provides a simple way to increase the completeness which besides allowing solving the structure, is also beneficial for the subsequent refinement.Fil: Rius, Jordi. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; EspañaFil: Vallcorba, Oriol. ALBA Synchrotron Light Source; EspañaFil: Crespi, Anna. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; EspañaFil: Colombo, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentin
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
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