1,721,255 research outputs found
Do the HIV-1 subtypes circulating in Italy resemble the Red Queen running in Carroll's novel?
No full textThe human immunodeficiency virus type 1 (HIV-1) pandemic is currently in its third decade and approximately 35 million people are infected worldwide. HIV-1 genetic variability results in 9 phylogenetic subtypes and several circulating recombinant forms (CRFs). In Italy, the first phase of the HIV epidemic was mainly confined to the intravenous drug users (IDU) risk group, moreover most studies have focused on different aspects of the non B subtype such as drugs and therapeutic protocols, laboratory methodologies (heteroduplex mobility assay, PCR screening methods) for the identification of phenotypic variants. These studies were mostly locally conducted. In this context, the Red Queen Hypothesis might be suggestive. In the first original expression that comes from Chapter 2, Through the Looking Glass. To improve our knowledge, in the near future, we will need to investigate the demographic and spatiotemporal history of different HIV-1 subtypes circulating in Italy in a large data set of sequences, involving a sample size comparable with the Italian population. To monitor the genetic evolution of the HIV-1 in a large data-set represent an essential strategy to control the local as well as the global HIV-1 epidemic and to develop efficient preventive and therapeutic strategies, with a great impact in clinical practice
Artificial intelligence in scientific research: Challenges, opportunities and the imperative of a human-centric synergy
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Monitoring the West Nile virus outbreaks in Italy using open access data
Full text link: This paper introduces a comprehensive dataset on West Nile virus outbreaks that have occurred in Italy from September 2012 to November 2022. We have digitized bulletins published by the Italian National Institute of Health to demonstrate the potential utilization of this data for the research community. Our aim is to establish a centralized open access repository that facilitates analysis and monitoring of the disease. We have collected and curated data on the type of infected host, along with additional information whenever available, including the type of infection, age, and geographic details at different levels of spatial aggregation. By combining our data with other sources of information such as weather data, it becomes possible to assess potential relationships between West Nile virus outbreaks and environmental factors. We strongly believe in supporting public oversight of government epidemic management, and we emphasize that open data play a crucial role in generating reliable results by enabling greater transparency
From crisis to resilience: challenges and solutions in managing the Marburg epidemic in Tanzania
No full textAssessing yellow fever and arboviral risks during the 2025 jubilee in Rome: A mass gathering and global mobility perspective
No full textDetection of SARS-CoV-2 Alpha variant in a severely immunocompromised HIV-1-infected patient in the omicron era
No full text: Persistence of detectable viral RNA does not depend on the symptomatic status of the patients. Here we describe the case of a strongly immunocompromised patient living with a prolonged SARSCoV-2 Alpha variant infection without showing any symptoms. The importance of our findings is that the persistent infection with an old SARS-CoV-2 strain, in an immunocompromised host, may allow recombination events generating new viral variants whose pathogenicity cannot be predicted. Our observation calls for the urgent need for continuous monitoring of SARS-CoV-2 genomic evolution in immunocompromised patients
Between cutting-edge guidelines and neglected vulnerabilities: an implementation agenda for HCC in the Asia–Pacific
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