8,043 research outputs found
Movement and center-of-pressure characteristics of multi-directional volitional stepping in healthy young adults.
No full textThe protein conformation and a zinc-binding domain of an autoantigen from mouse seminal vesicle.
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Effects of aging and direction on movement and center-of-pressure characteristics of volitional stepping.
No full textAltered muscle activation characteristics associated with single volitional forward stepping in middle-aged adults
No full textHIGH RESOLUTION FOURIER TRANSFORM EMISSION SPECTROSCOPY OF YH AND YD.
No full textAuthor Institution: Department of Chemistry, University of Arizona; Department of Chemistry, University of WaterlooThe electronic emission spectrum of YH and YD has been investigated in the 690 nm to 3 spectral region using a Fourier transform spectrometer. The YH and YD bands were excited in an yttrium hollow cathode lamp operated with neon gas and a trace of of The observed bands have been classified into three different electronic transitions; and . The transition of YD could not be identified due to its very weak intensity. The rotational analysis of several bands of the transition (up to for YH and for YD) provides improved equilibrium vibrational and rotational constants for the ground state of YH and YD. The excited state is involved in several perturbations
Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice
No full textAim: 7-O-ethylfangchinoline (YH-200) is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant-like action and underlying mechanisms of YH-200 in mice. Methods: Mice were treated with YH-200 (15, 30, and 60 mg/kg, ig) or tetrandrine (30 and 60 mg/kg, ig) before conducting forced swimming test (FST), tail suspension test (TST), or open field test (OFT). Results: YH-200 (60 mg/kg) significantly decreased the immobility time in both FST and TST, and prolonged the latency to immobility in FST. YH-200 (60 mg/kg) was more potent than the natural bisbenzylisoquinoline alkaloid tetrandrine (60 mg/kg) in FST. Pretreatment with alpha(1)-adrenoceptor antagonist prazosin (1 mg/kg), beta-adrenoceptor antagonist propranolol (2 mg/kg), dopamine D-1/D-5 receptor antagonist SCH23390 (0.05 mg/kg), dopamine D-2/D-3 receptor antagonist haloperidol (0.2 mg/kg) or AMPA receptor antagonist NBQX (10 mg/kg) prevented the antidepressant-like action of YH-200 (60 mg/kg) in FST. In contrast, pretreatment with alpha(2) adrenoceptor antagonist yohimbine (1 mg/kg) augmented the antidepressant-like action of YH-200 (30 mg/kg) in FST. Chronic administration of YH-200 (30 and 60 mg/kg for 14 d) did not produce drug tolerance; instead its antidepressant-like action was strengthened. Chronic administration of YH-200 did not affect the body weight of mice compared to control mice. Conclusion: YH-200 exerts its antidepressant-like action in mice via acting at multi-targets, including alpha(1), alpha(2) and beta-adrenoceptors, D-1/D-5 and D-2 /D-3 receptors, as well as AMPA receptors.National Natural Science Foundation of China [81173031, 81202511, 81302746]SCI(E)PubMed中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)[email protected]
Recurrent advancing wavelike epitheliopathy from the opposite side of the initial presentation.
No full textThe phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells.
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