1,721,107 research outputs found
Evolution of postzygotic isolation between subspecies of Clarkia xantiana
No full textThis research was supported by the Undergraduate Research Opportunities Program (UROP).Chu, Eric. (2013). Evolution of postzygotic isolation between subspecies of Clarkia xantiana. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/150118
Experiment level curation identifies high confidence transcriptional regulatory interactions in neurodevelopment
No full textThe capacity to computationally reconstruct gene regulatory networks using large-scale biological data is currently limited by the absence of a high confidence set of one-to-one regulatory interactions. Given the lengthy history of using small scale experimental assays to investigate individual interactions, we hypothesize that a reliable collection of gene regulatory interactions could be compiled by systematically inspecting the published literature. To this end, we developed a curation protocol to examine and record evidence of regulatory interactions at the individual experiment level. Focusing on the area of brain development, we applied our pipeline to 1,310 publications. We identified 3,601 individual experiments, providing detailed information about 1,499 regulatory interactions. Many of these interactions have verified activity specifically in the embryonic brain. By capturing reports of regulatory interactions at this level of granularity, we present a resource that is more interpretable than other similar resources.
List of Tables in TSV format:
Supplementary Table S1. List of candidate papers
Supplementary Table S2. List of TFs
Supplementary Table S3. Curated records at the experiment level
Supplementary Table S4. Curated records summarized at the DTRI level
Supplementary Table S5. TF Perturbation experiment details
Supplementary Table S6. TF-DNA Binding experiment details
Supplementary Table S7. TF-reporter experiment details
Supplementary Table S8. All DTRI records including those curated in external databases
Supplementary Table S9. Records obtained from external databases
Supplementary Table S10. List of differentially expressed genes following Pax6 perturbation
Supplementary Table S11. Experiments with negative results
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Between Policies, Programs, and Projects::How Local Actors Steer Domestic Urban Climate Adaptation Finance in India
No full textIn light of the slow progress in mobilizing international finance for climate adaptation in developing countries, a growing body of research promotes the idea of pooling blended forms of climate finance to leverage limited financial flows and enhance domestic control over allocation and accountability. Yet the constraints imposed by weaknesses in existing urban public finance institutions complicates perspectives on climate finance that envision the smooth pooling of blended finance from multiple sources across multiple scales. This chapter presents the case of Surat in India to illustrate how city governments can sustain an innovative approach to local climate adaptation while switching between various sources of funding. In this chapter, we ask two research questions: How do local governments that wish to pursue climate adaptation, often outside a comprehensive planning framework, steer these efforts around the numerous institutional, operational, and political constraints at the local level? Second, when the pursuit of climate adaptation is supported by time-bound external funding sources, how do local governments sustain action while switching between different types of financial flows? In the case of Surat, we find that the city is beginning to intentionally draw on intergovernmental fiscal transfers and, increasingly, their own local revenue resources. Such an implementation pathway emerges from the local government’s ability to innovatively identify specific adaptation and development co-benefits and to exploit this with projects funded by existing and forthcoming streams of public revenue. Surat’s experience suggests that, in contrast to pooling, cities will have to strategically steer climate adaptation action around local fiscal constraints created by the different governance logics associated with policies, programs, and projects
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Introduction
No full textCities are increasingly shaping the trajectory and impacts of climate change. While local actors play a central role in designing the institutions, infrastructures, and behaviors that drive decarbonization and adaptation to changing climatic conditions, their options and incentives are inextricably enmeshed within broader political and economic processes. Resolving these tensions and contradictions is likely to require innovative approaches to governing climate change in the city: new interactions, new political actors, new ways of coordinating and mobilizing resources, and new frameworks and technical capacities for decision-making. This book presents pioneering work on the range of innovative practices, experiments, and ideas that are becoming an integral part of urban climate change governance in the twenty-first century. Theoretically, the book builds on a nearly two-decade history of scholarship identifying the emergence of new urban actors, spaces, and political dynamics in response to climate change. Empirically, the chapters investigate new governance arrangements from around the world and leverage the insights they provide for both theory and practice. The book is organized around four guiding questions: 1) how do multilevel governance arrangements relate to innovation for urban climate change governance? 2) where is the greatest need for innovation? 3) where is innovation difficult or stifled? 4) how can innovation be fostered and encouraged in a multilevel governance context
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